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91.
M.J. van Tricht D.H. Nieman L.J. Bour T. Boerée J.H.T.M. Koelman L. de Haan D.H. Linszen 《Brain and cognition》2010
Abnormalities in eye tracking are consistently observed in schizophrenia patients and their relatives and have been proposed as an endophenotype of the disease. The aim of this study was to investigate the performance of patients at Ultra High Risk (UHR) for developing psychosis on a task of smooth pursuit eye movement (SPEM). Forty-six UHR patients and twenty-eight age and education matched controls were assessed with a task of SPEM and psychiatric questionnaires. Our results showed that both the corrective and non-corrective saccadic rates during pursuit were higher in the UHR group. There were however no differences in smooth pursuit gain between the two groups. The saccadic rate was related to positive UHR symptoms. Our findings indicate that abnormalities in SPEM are already present in UHR patients, prior to a first psychotic episode. These abnormalities occur only in the saccadic system. 相似文献
92.
Non-visual gaze patterns (NVGPs) involve saccades and fixations that spontaneously occur in cognitive activities that are not ostensibly visual. While reasons for their appearance remain obscure, convergent empirical evidence suggests that NVGPs change according to processing requirements of tasks. We examined NVPGs in tasks with long-term memory (LTM) and working memory (WM) requirements. Experiment 1 yielded significantly higher eye movement rate (EMR) in tasks requiring LTM search than in a WM task requiring maintenance of information. Experiment 2 manipulated accessibility of items in study-test episodic tasks using the levels of processing paradigm. EMR was high in episodic recall irrespective of item accessibility. Experiment 3 examined functional significance of saccades in LTM tasks. Voluntary saccadic suppression produced no evidence that saccades contribute to task performance. We discuss the apparent epiphenomenal nature of spontaneous saccades from an evolutionary perspective and outline a neuroanatomical model of the link between the saccadic and memory system. 相似文献
93.
本研究采用两项实验考察学龄前儿童正字法意识的发展情况。实验1选取146名4~7岁儿童被试,要求其在计算机上完成词汇判断任务,刺激材料分为部件错误非字,部件位置错误非字,假字和真字。结果显示:大班在两项非字条件上的正确率均显著高于假字,而小班各条件差异均不显著;中班在部件位置错误非字上的正确率显著高于假字。表明学龄前儿童的正字法意识已经开始逐渐发展,且部件位置意识比部件意识容易获得。实验2采用Tobii T120型眼动仪,记录24名大班儿童在词汇判断(同实验1)过程中对刺激项目关注的眼动行为,从实时加工的过程探讨学龄前儿童正字法意识的发展。结果显示:儿童对部件错误非字/部件位置错误非字的目标部件的晚期关注程度显著高于假字,有力地证明:学龄前大班儿童已经具有部件和部件位置的意识。 相似文献
94.
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96.
采用眼动追踪技术,考察重复阅读对母语为汉语的大学生阅读英语语篇的作用。研究采用2(目标词词频:高频、低频)×5(阅读遍数:1遍、2遍、3遍、4遍、5遍)的两因素被试内设计。结果发现:(1)随着阅读遍数的增加,读者的阅读理解正确率呈上升趋势,总阅读时间、注视次数、回视次数和平均注视时间显著降低,平均眼跳幅度显著增加;(2)阅读遍数与目标词词频的交互作用显著,表现为重复阅读对低频词识别的促进作用要显著大于对高频词识别的促进作用。研究表明重复阅读能够有效提高大学生对英语语篇的阅读效率。 相似文献
97.
Pharmacological treatment effects on eye movement control 总被引:1,自引:1,他引:0
James L. Reilly Rebekka Lencer Jeffrey R. Bishop Sarah Keedy John A. Sweeney 《Brain and cognition》2008,68(3):415
The increasing use of eye movement paradigms to assess the functional integrity of brain systems involved in sensorimotor and cognitive processing in clinical disorders requires greater attention to effects of pharmacological treatments on these systems. This is needed to better differentiate disease and medication effects in clinical samples, to learn about neurochemical systems relevant for identified disturbances, and to facilitate identification of oculomotor biomarkers of pharmacological effects. In this review, studies of pharmacologic treatment effects on eye movements in healthy individuals are summarized and the sensitivity of eye movements to a variety of pharmacological manipulations is established. Primary findings from these studies of healthy individuals involving mainly acute effects indicate that: (i) the most consistent finding across several classes of drugs, including benzodiazepines, first- and second- generation antipsychotics, anticholinergic agents, and anticonvulsant/mood stabilizing medications is a decrease in saccade and smooth pursuit velocity (or increase in saccades during pursuit); (ii) these oculomotor effects largely reflect the general sedating effects of these medications on central nervous system functioning and are often dose-dependent; (iii) in many cases changes in oculomotor functioning are more sensitive indicators of pharmacological effects than other measures; and (iv) other agents, including the antidepressant class of serotonergic reuptake inhibitors, direct serotonergic agonists, and stimulants including amphetamine and nicotine, do not appear to adversely impact oculomotor functions in healthy individuals and may well enhance aspects of saccade and pursuit performance. Pharmacological treatment effects on eye movements across several clinical disorders including schizophrenia, affective disorders, attention deficit hyperactivity disorder, Parkinson’s disease, and Huntington’s disease are also reviewed. While greater recognition and investigation into pharmacological treatment effects in these disorders is needed, both beneficial and adverse drug effects are identified. This raises the important caveat for oculomotor studies of neuropsychiatric disorders that performance differences from healthy individuals cannot be attributed to illness effects alone. In final sections of this review, studies are presented that illustrate the utility of eye movements for use as potential biomarkers in pharmacodynamic and pharmacogenetic studies. While more systematic studies are needed, we conclude that eye movement measurements hold significant promise as tools to investigate treatment effects on cognitive and sensorimotor processes in clinical populations and that their use may be helpful in speeding the drug development pathway for drugs targeting specific neural systems and in individualizing pharmacological treatments. 相似文献
98.
Apraxia of Speech (AOS) is an impairment of motor programming. However, the exact nature of this deficit remains unclear. The present study examined motor programming in AOS in the context of a recent two-stage model [Klapp, S. T. (1995). Motor response programming during simple and choice reaction time: The role of practice. Journal of Experimental Psychology: Human Perception and Performance, 21, 1015–1027; Klapp, S. T. (2003). Reaction time analysis of two types of motor preparation for speech articulation: Action as a sequence of chunks. Journal of Motor Behavior, 35, 135–150] that proposes a preprogramming stage (INT) and a process that assigns serial order to multiple programs in a sequence (SEQ). The main hypothesis was that AOS involves a process-specific deficit in the INT (preprogramming) stage of processing, rather than in the on-line serial ordering (SEQ) and initiation of movement. In addition, we tested the hypothesis that AOS involves a central (i.e., modality-general) motor programming deficit. We used a reaction time paradigm that provides two dependent measures: study time (the amount of time for participants to ready a motor response; INT), and reaction time (time to initiate movement; SEQ). Two experiments were conducted to examine INT and SEQ in AOS: Experiment 1 involved finger movements, Experiment 2 involved speech movements analogous to the finger movements. Results showed longer preprogramming time for patients with AOS but normal sequencing and initiation times, relative to controls. Together, the findings are consistent with the hypothesis of a process-specific, but central (modality-independent) deficit in AOS; alternative explanations are also discussed. 相似文献
99.
In the present study we considered the two factors that have been advocated for playing a role in emotional attention: perception
of gaze direction and facial expression of emotions. Participants performed an oculomotor task in which they had to make a
saccade towards one of the two lateral targets, depending on the colour of the fixation dot which appeared at the centre of
the computer screen. At different time intervals (stimulus onset asynchronies, SOAs: 50,100,150 ms) following the onset of
the dot, a picture of a human face (gazing either to the right or to the left) was presented at the centre of the screen.
The gaze direction of the face could be congruent or incongruent with respect to the location of the target, and the expression
could be neutral or angry. In Experiment 1 the facial expressions were presented randomly in a single block, whereas in Experiment
2 they were shown in separate blocks. Latencies for correct saccades and percentage of errors (saccade direction errors) were
considered in the analyses. Results showed that incongruent trials determined a significantly higher percentage of saccade
direction errors with respect to congruent trials, thus confirming that gaze direction, even when task-irrelevant, interferes
with the accuracy of the observer’s oculomotor behaviour. The angry expression was found to hold attention for a longer time
with respect to the neutral one, producing delayed saccade latencies. This was particularly evident at 100 ms SOA and for
incongruent trials. Emotional faces may then exert a modulatory effect on overt attention mechanisms. 相似文献
100.
Filik R 《Cognition》2008,106(2):1038-1046
Readers typically experience processing difficulty when they encounter a word that is anomalous within the local context, such as 'The mouse picked up the dynamite...'. The research reported here demonstrates that by placing a sentence in a fictional scenario that is already well known to the reader (e.g., a Tom and Jerry cartoon, as a context for the example sentence above), the difficulty usually associated with these pragmatic anomalies can be immediately eliminated, as reflected in participants' eye movement behaviour. This finding suggests that readers can rapidly integrate information from their common ground, specifically, their cultural knowledge, whilst interpreting incoming text, and provides further evidence that incoming words are immediately integrated within the global discourse. 相似文献