胃肠道干细胞

胃肠道是人体内各系统细胞更新频率最高的器官,其干细胞的增生分化也很旺盛。尽管胃肠道干细胞本身未分化成熟,其细胞表型无法确认而不利于鉴别,但随着一些干细胞标志物的发现及对细胞信号传导通路的不断了解,我们对胃肠道干细胞的调控机制的认识正在不断加深。胃肠道干细胞的基本特征:(1)胃肠道干细胞的数量、定位和组织起源;(2)胃肠道干细胞的主要功能,包括分化转化成胃肠道各成熟的细胞系及维持组织的动态平衡和稳定;(3)从其他组织的干细胞获得胃肠组织细胞系用以胃肠道疾病的治疗;(4)胃肠道组织癌变的基因变化及形态学观察。     

学习困难儿童在工作记忆任务中抑制机制的研究

本研究的目的旨在探讨在WM任务中,LD儿童是否存在抑制机制缺陷。实验程序采用重复启动范式,设计“预期”和“目标”两种启动条件,随后通过间接测量的方式(内隐记忆测验)分别测得LD儿童和NLD儿童对预期词和目标词的启动量。结果表明,LD儿童对预期词的启动分数与目标词没有显著差异,NLD儿童对目标词的启动分数显著高于对预期词的启动分数。我们得出结论:在工作记忆任务中,LD儿童存在抑制机制缺陷。     

策略型学习者认知心理结构及其运行机制

高效率学习是现代社会发展的需要,也是适应信息量急增的社会变革需要的必然选择。从教育心理学的视角研究策略型学习者,对其高效率学习心理,特别是高效率学习认知心理结构及其运行机制进行研究,有助于教育理论与实践工作者准确把握这类特殊教育对象的心理特点与规律,为开展策略型学习者教育提供了心理学依据。     

双语者代码切换的认知与神经机制——从行为研究到脑成像研究

双语者代码切换的机制已引起心理语言学家和认知神经科学家的广泛关注。研究分别在行为层面和神经机制层面展开。发现,双语者在进行代码切换时会出现切换代价,切换代价来源于心理词典外部的语言任务图式之间的竞争,其机制可能与中央执行控制机制有密切联系,左侧额下回、双侧缘上回和背外侧前额叶等脑区参与了双语者的代码切换过程。文章还分析了在这一领域仍待研究的一些问题,并提出了进一步开展双语代码切换研究的建议。     

WHY I AM AN ACCOMMODATIONIST AND PROUD OF IT

There is a strong need of a reasoned defense of what was known as the “independence” position of the science–religion relationship but that more recently has been denigrated as the “accommodationist” position, namely that while there are parts of religion—fundamentalist Christianity in particular—that clash with modern science, the essential parts of religion (Christianity) do not and could not clash with science. A case for this position is made on the grounds of the essentially metaphorical nature of science. Modern science functions because of its root metaphor of the machine: the world is seen in mechanical terms. As Thomas Kuhn insisted, metaphors function in part by ruling some questions outside their domain. In the case of modern science, four questions go unasked and hence unanswered: Why is there something rather than nothing? What is the foundation of morality? What is mind and its relationship to matter? What is the meaning of it all? You can remain a nonreligious skeptic on these questions, but it is open for the Christian to offer his or her answers, so long as they are not scientific answers. Here then is a way that science and religion can coexist.     

Improving Delivery Behaviors During Exposure for Pediatric OCD: A Multiple Baseline Training Trial With Community Therapists

This study tested whether a new training tool, the Exposure Guide (EG), improved in-session therapist behaviors (i.e., indicators of quality) that have been associated with youth outcomes in prior clinical trials of exposure therapy. Six therapists at a community mental health agency (CMHA) provided exposure therapy for 8 youth with obsessive–compulsive disorder (OCD). Using a nonconcurrent multiple baseline design with random assignment to baseline lengths of 6 to 16 weeks, therapists received gold-standard exposure therapy training with weekly consultation (baseline phase) followed by addition of EG training and feedback (intervention phase). The primary outcome was therapist behavior during in-session exposures, observed weekly using a validated coding system. Therapist behavior was evaluated in relation to a priori benchmarks derived from clinical trials. Additional outcomes included training feasibility/acceptability, therapist response to case vignettes and beliefs about exposure, and independent evaluator-rated clinical outcomes. Three therapists reached behavior benchmarks only during the EG (intervention) phase. Two therapists met benchmarks during the baseline phase; one of these subsequently moved away from benchmarks but met them again after starting the EG phase. Across all therapists, the percentage of weeks meeting benchmarks was significantly higher during the EG phase (86.4%) vs. the baseline phase (53.2%). Youth participants experienced significant improvement in OCD symptoms and global illness severity from pre- to posttreatment. Results provide initial evidence that adding the EG to gold-standard training can change in-session therapist behaviors in a CMHA setting.     

自传记忆的加工机制研究进展

自传记忆是关于个人生活经验的记忆,它有悖于Ehbinghaus的记忆研究传统。在国外．90年代以来自传记忆研究已成为继内隐记忆研究后．记忆领域的又一研究热点。自传记忆加工机制的研究是认知心理学对自传记忆研究的核心领域。本文主要评析了自传记忆的知识表征．自传记忆提取机制的研究进展。目前已有的研究结论是：（1）自传记忆是以个人生活片段知识、一般事件知识和具体事件知识三种方式表征的;（2）自传记忆的提取方式主要通过生成提取和直接提取方式来实现。     

多发性硬化患者外周血CD4＋CD25＋T细胞与可溶性细胞因子表达的相关性研究

CD4＋CD25＋T细胞和可溶性细胞因子在多发性硬化（multiple sclerosis,MS）发生和发展中起重要作用。本文通过探讨MS患者外周血CD4＋CD25＋T细胞数量及可溶性细胞因子与MS病情的关系,为进一步研究MS的发病机制和采取有效治疗措施奠定了基础。     

基于非逻辑机制的条件推理模式：P—Q映射模型及其实证检验

研究结合数学分析方法,提出了基于非逻辑机制的条件推理模型：P-Q映射模型。并根据这个模型,对人们在不同命题类型奈件下的推理行为进行了预测。预测结果显示,当推理前提为LH和HL型命题时,基于P-Q映射模型的预测结果与基于条件概率模型的预测结果完全一致。但当推理前提为LL和HH型命题时,两种模型给出的预测结果存在差异。实验结果表明,当前提命题为LL和HH型命题时,被试的条件推理行为与P-Q映射模型的预言完全一致。     

急性应激对威胁刺激注意定向和注意解除的影响:认知神经机制研究

急性应激和注意偏向是焦虑障碍和创伤后应激障碍发生和症状保持的两个重要因素。急性应激导致交感神经系统激活以及儿茶酚胺和糖皮质激素分泌增加,因而影响对威胁刺激的注意偏向。但是急性应激如何影响注意偏向中的注意定向和注意解除尚不清楚。本项目采用点探测任务、威胁线索空间提示任务,结合恐惧条件反射、眼动和事件相关电位技术,研究急性应激对注意定向和注意解除影响的认知神经机制。研究结果可为治疗焦虑和创伤后应激障碍提供支持,为公共卫生管理政策的制定提供建议。