Effects of Temporal Lobe Lesions on Retrograde Memory: A Critical Review

Scientific interest in retrograde memory has grown considerably over the last two decades. Studies have demonstrated that several brain regions, including the temporal lobes, participate in the formation, maintenance and storage of past memories. Different patterns and extents of retrograde memory deficits have been recorded in patients with temporal lobe lesions. It has been argued that the pattern of retrograde memory deficits is determined not only by the side and specific location of lesion within this region, but also by methodology, medical variables (such as etiology or seizure history), and coexisting cognitive deficits. In this paper we will review published case and group studies of patients with temporal lobe lesions to evaluate the impact of these factors on retrograde memory.     

Reactivated memory of an inhibitory avoidance response in mice is sensitive to a nitric oxide synthase inhibitor

It is accepted that once consolidation is completed memory becomes permanent. However, it has also been suggested that reactivation (retrieval) of the original memory, again, makes it sensitive to the same treatments that affect memory consolidation when given after training. Previous results demonstrated that the immediate post-training intraperitoneal administration of N^ω-nitro-l-arginine methyl ester (L-NAME), a non-specific inhibitor of nitric oxide synthase (NOS), impairs retention test performance of a one-trial step-through inhibitory avoidance response in adult mice. The effect of L-NAME on retention was attributed to an action on memory consolidation of the original learning. For the first time, we report that the administration of L-NAME after the first retention test (memory reactivation) of the inhibitory avoidance response impairs retention performance over six consecutive days. This impairment effect is dose-and-time dependent and could not be attributed to a retrieval deficit since a mild footshock did not reinstate the original avoidance response and no spontaneous recovery was observed at least 21 days after training. Further support for a storage deficit interpretation as opposed to a retrieval deficit was obtained from the fact that L-NAME’s effects after retrieval were not due to state-dependency. The impairment effect of L-NAME was dependent on the age of the original memory. That is, there was an inverse correlation between the susceptibility of the memory trace when reactivated and the time elapsed between training and the first retrieval session. We suggest an action of L-NAME on memory reactivation-induced processes that are different from memory extinction of the original learning extending the biological significance of nitric oxide on memory.     

试论肿瘤治疗思维应从对抗向和谐转换

当前对抗性模式主导下的肿瘤治疗,有其特定的哲学基础,即以溯因分析的方法,主张对疾病的明朗化,视疾病为异端,采取对抗性的治疗将其斩尽杀绝,由此带来了肿瘤治疗所面临的一系列问题,从自然哲学的角度看,人类需要和无数物种共存,包括肿瘤细胞,自然界生态平衡的破坏已经给人类带来了灾难,由此反思肿瘤的治疗,我们需摒弃既往的对抗性思维...     

Cholinergic dependence of taste memory formation: evidence of two distinct processes

Learning the aversive or positive consequences associated with novel taste solutions has a strong significance for an animal's survival. A lack of recognition of a taste's consequences could prevent ingestion of potential edibles or encounter death. We used conditioned taste aversion (CTA) and attenuation of neophobia (AN) to study aversive and safe taste memory formation. To determine if muscarinic receptors in the insular cortex participate differentially in both tasks, we infused the muscarinic antagonists scopolamine at distinct times before or after the presentation of a strong concentration of saccharin, followed by either an i.p. injection of a malaise-inducing agent or no injection. Our results showed that blockade of muscarinic receptors before taste presentation disrupts both learning tasks. However, the same treatment after the taste prevents AN but not CTA. These results clearly demonstrate that cortical cholinergic activity participates in the acquisition of both safe and aversive memory formation, and that cortical muscarinic receptors seem to be necessary for safe but not for aversive taste memory consolidation. These results suggest that the taste memory trace is processed in the insular cortex simultaneously by at least two independent mechanisms, and that their interaction would determine the degree of aversion or preference learned to a novel taste.     

EQUIVALENCE CLASS FORMATION IN A TRACE STIMULUS PAIRING TWO‐RESPONSE FORMAT: EFFECTS OF RESPONSE LABELS AND PRIOR PROGRAMMED TRANSITIVITY INDUCTION

Three experiments identified factors that did and did not enhance the formation of two‐node four‐member equivalence classes when training and testing were conducted with trials presented in a trace stimulus pairing two‐response (SP2R) format. All trials contained two separately presented stimuli. Half of the trials, called within‐class trials, contained stimuli from the same class while the other half, called cross class trials, contained stimuli from different classes. On within class trials, making a YES response was correct and making a NO response was wrong. On cross class trials, making a NO response was correct and making a YES response was wrong. In Experiment 1, similar intermediate percentages of participants (about 50%) formed classes, regardless of whether the responses were labeled YES and NO or SAME and DIFF. Response labeling thus did not influence class formation. Regardless of response labels, failures of class formation were primarily due to failure of class‐indicative responding produced by within‐class transitivity probes. In Experiment 2, only 50% of participants formed classes without prior training, as in Experiment 1, but 100% of participants formed equivalence classes after the establishment of a generalized transitivity repertoire by use of a programmed transitivity induction protocol. Experiment 3 examined two components of the programmed transitivity induction protocol and found that the exclusion of AC trials had no effect on the percentage of participants who formed equivalence classes, while presenting the stimulus sets in randomized order interfered with equivalence class formation. A further analysis found that a number of stimulus control topographies differentiated between individuals who did and did not form equivalence classes. In general, then, these experiments demonstrate that equivalence classes can be formed reliably when training and testing are conducted in an SP2R format, supporting the view that equivalence class formation can account for the development of conceptual categories in natural settings.     

The asymptotic bias of minimum trace factor analysis, with applications to the greatest lower bound to reliability

In theory, the greatest lower bound (g.l.b.) to reliability is the best possible lower bound to the reliability based on single test administration. Yet the practical use of the g.l.b. has been severely hindered by sampling bias problems. It is well known that the g.l.b. based on small samples (even a sample of one thousand subjects is not generally enough) may severely overestimate the population value, and statistical treatment of the bias has been badly missing. The only results obtained so far are concerned with the asymptotic variance of the g.l.b. and of its numerator (the maximum possible error variance of a test), based on first order derivatives and the asumption of multivariate normality. The present paper extends these results by offering explicit expressions for the second order derivatives. This yields a closed form expression for the asymptotic bias of both the g.l.b. and its numerator, under the assumptions that the rank of the reduced covariance matrix is at or above the Ledermann bound, and that the nonnegativity constraints on the diagonal elements of the matrix of unique variances are inactive. It is also shown that, when the reduced rank is at its highest possible value (i.e., the number of variables minus one), the numerator of the g.l.b. is asymptotically unbiased, and the asymptotic bias of the g.l.b. is negative. The latter results are contrary to common belief, but apply only to cases where the number of variables is small. The asymptotic results are illustrated by numerical examples.This research was supported by grant DMI-9713878 from the National Science Foundation.