Tolerance to and residual effects of cocaine in squirrel monkeys depend on reinforcement-schedule parameter.

Lever pressing by 4 squirrel monkeys was maintained under a three-component multiple fixed-ratio schedule of food presentation; components differed with respect to ratio size. For each monkey, acute administration of cocaine (0.03 to 1.3 mg/kg, i.m.) produced dose-dependent decreases in overall response rate in each component. During repeated daily administration of 1.0 mg/kg of cocaine, tolerance developed to the rate-decreasing effects under each of the ratio contingencies, but developed to a greater extent and was evident in earlier parts of sessions for performance under the smaller ratios. Response rates of 2 monkeys increased above nondrug control levels despite the putative reinforcer not being consumed during the session. When saline or a smaller dose of cocaine was substituted for 1.0 mg/kg, response rates often were suppressed below nondrug control-level responding. This suppressive effect was observed in each monkey and was more likely to be observed and/or to be of greater magnitude in large-ratio components for 3 of the 4 monkeys. When saline was administered chronically at the end of the chronic-drug phase, response rates remained suppressed in the large-ratio component for 2 of the monkeys. There was, therefore, a schedule-dependent dissociation between behavioral tolerance and the residual effects: Tolerance was greater when small ratios were arranged, whereas the residual effects were more pronounced when larger ratios were arranged.     

The Power of Language and Labels: “The Mentally Ill” Versus “People With Mental Illnesses”

Undergraduate students (N = 221), adults in a community sample (N = 211), and professional counselors and counselors‐in‐training (N = 269) were given a measure of tolerance. Within each sample, half of the participants were given a version that used the term “the mentally ill” and half were given a version that used the term “people with mental illnesses.” Individuals receiving the version with the term “the mentally ill” had lower levels of tolerance. Professional counselors had the largest differences in tolerance on the basis of language.     

Beyond inference by eye: Statistical and graphing practices in JEAB, 1992‐2017

Debates about the utility of p values and correct ways to analyze data have inspired new guidelines on statistical inference by the American Psychological Association (APA) and changes in the way results are reported in other scientific journals, but their impact on the Journal of the Experimental Analysis of Behavior (JEAB) has not previously been evaluated. A content analysis of empirical articles published in JEAB between 1992 and 2017 investigated whether statistical and graphing practices changed during that time period. The likelihood that a JEAB article reported a null hypothesis significance test, included a confidence interval, or depicted at least one figure with error bars has increased over time. Features of graphs in JEAB, including the proportion depicting single‐subject data, have not changed systematically during the same period. Statistics and graphing trends in JEAB largely paralleled those in mainstream psychology journals, but there was no evidence that changes to APA style had any direct impact on JEAB. In the future, the onus will continue to be on authors, reviewers and editors to ensure that statistical and graphing practices in JEAB continue to evolve without interfering with characteristics that set the journal apart from other scientific journals.     

Assessing the generality and durability of interview‐informed functional analyses and treatment

Due to the limited research demonstrating socially valid outcomes of function‐based treatments in ecologically relevant environments (Santiago, Hanley, Moore, & Jin, 2016), we replicated and extended the effects of the interview‐informed functional analysis and skill‐based treatment procedure described by Hanley, Jin, Vanselow, and Hanratty (2014) with two children diagnosed with autism in a home setting. The assessment and treatment was implemented by a home‐based service provider and treatment was extended to the participants’ parents. Following the interview‐informed functional analyses, we taught the participants functional communication responses and to engage in less‐preferred activities when functional communication outcomes were delayed. We observed large reductions in problem behavior following the introduction of the function‐based treatment. The effects extended to novel settings, stimuli, and caregivers and the results maintained at 6‐week follow‐ups.     

The Influence of Existential Threat and Tolerance Salience on Anti‐Islamic Attitudes in American Politics

Fierce public discussion has centered on anti‐Islamic attitudes and tolerance in America and the West more broadly. The present research explored whether the awareness of mortality (a common theme in politics, e.g., war/terrorism, health care, abortion, and so on) and tolerance salience might influence (1) the endorsement of anti‐Islamic attitudes in American politics and (2) political orientation. Study 1 (n = 79) was conducted in lab and Study 2 (preregistered, n = 396) replicated it online; both obtained the same results. In a neutral‐value‐prime condition, American participants reminded of mortality (vs. control topic) more strongly endorsed a Congressman’s anti‐Islamic statements about Rep. Ellison. However, in a tolerance‐value‐prime condition, participants reminded of mortality maintained their acceptance of Rep. Ellison’s beliefs and practices. Political orientation was not impacted. Implications for terror management theory (TMT), other theories of existential dynamics and motivated conservative political ideology, and both recent and contemporary American politics are discussed.     

Contrast effects in judgmental forecasting when assessing the implications of worst and best case scenarios

Two experiments investigated whether individuals' forecasts of the demand for products and a stock market index assuming a best or worst case scenario depend on whether they have seen a single scenario in isolation or whether they have also seen a second scenario presenting an opposing view of the future. Normatively, scenarios should be regarded as belonging to different plausible future worlds so that the judged implications of one scenario should not be affected when other scenarios are available. However, the results provided evidence of contrast effects in that the presentation of a second “opposite” scenario led to more extreme forecasts consistent with the polarity of the original scenario. In addition, people were more confident about their forecasts based on a given scenario when two opposing scenarios were available. We examine the implications of our findings for the elicitation of point forecasts and judgmental prediction intervals and the biases that are often associated with them.     

Is the Association Between Multicultural Personality and Ethnic Tolerance Explained by Cross-Group Friendship?

The present study reports on the relations between multicultural personality and ethnic tolerance via associations with cross-group friendship in a sample of Portuguese university students (n = 270). It was found that the multicultural personality dimensions, particularly cultural empathy, open-mindedness, social initiative, and flexibility, were significantly correlated with ethnic tolerance. At the same time, a mediation model demonstrated that the relationship between open-mindedness and ethnic tolerance was partially mediated by cross-group friendship. In addition, emotional stability was found to be indirectly related to ethnic tolerance via its association with cross-group friendship. These findings highlight the importance of considering individual and contact variables in promoting tolerance toward representatives of diverse ethnic and cultural groups.     

Are the ethnically tolerant free of discrimination,prejudice and political intolerance?

We hypothesized that the ethnically tolerant (i.e., people who are anti‐ethnocentric and score very low on a measure of ethnocentrism) would perceive people with extremely incompatible values and beliefs as out‐groups and would engage in discrimination, prejudice and political intolerance against them. Experiments among Australian citizens in Studies 1 (N = 224) and 2 (N = 283) showed that the ethnically tolerant perceived supporters of a message in favour of mandatory detention of asylum seekers as out‐groups and consequently exhibited discrimination, prejudice and political intolerance against them. Study 3 with 265 U.S. citizens showed that, controlling for liberalism, ethnic tolerance led to prejudice against out‐groups. This was replicated with 522 UK citizens in Study 4, which also showed that social identity, and not moral conviction, mediated the link between ethnic tolerance and prejudice. The findings suggest that the ethnically tolerant can be discriminatory, prejudiced and politically intolerant against fellow humans.     

The Emotional Foundation of Political Cognition: The Impact of Extrinsic Anxiety on the Formation of Political Tolerance Judgments

Common sense recognizes emotion's ability to influence judgments. We argue that affective processes, in addition to generating feeling states, also influence how political cognition is manifested. Drawing on the theory of affective intelligence, we examine the role that anxiety plays in how and when people rely on predispositions and when they rely on contemporaneous information in making political tolerance judgments. We report on two experimental studies to test our arguments. In the first study we find that extrinsic anxiety generates a resistance response among subjects who hold a strong predisposition and a receptive response among those who do not. In the second study we present subjects with explicit "frames" exposing them to a pro- or anti-free speech message. We find that extrinsic anxiety enhances responsiveness to frames while an absence of anxiety diminishes the impact of these frames. Taken together these results show that affective processes shape how people make political judgments.     

通过打破抗原特异性T细胞免疫耐受控制慢性HBV感染

乙型肝炎病毒(HBV)感染诱导机体抗病毒免疫应答,若不能对病毒有效清除,体内抗原特异的CTL降低,出现抗原特异性T细胞免疫耐受,造成慢性肝脏炎症。分析HBV感染时抗原特异性T细胞免疫耐受机制,并通过打破免疫耐受预防HBV感染。