经颅直流电刺激技术在物质依赖治疗中的应用

物质依赖是一种慢性、复发性脑部疾病, 给个体及社会带来极大损害。研究发现, 经颅直流电刺激(transcranial direct current stimulation, tDCS)可以通过调节背外侧前额叶(dorsolateral prefrontal cortex, DLPFC)脑区的兴奋性降低物质依赖者的渴求, 并改善受损的认知功能。tDCS具有副作用小、操作简便、费用低廉等优点, 因此在物质依赖治疗领域应用前景广泛。未来应考虑确定最佳的刺激参数及刺激位置, 同时考虑物质依赖者的种类及个体差异, 与其他疗法结合使用, 并进一步深入探索tDCS治疗物质依赖的神经机制。     

Quality of life after quitting smoking and initiating aerobic exercise

Quitting smoking and aerobic exercise each improve health. Although smokers may be concerned that quitting smoking will reduce their quality of life (QOL), recent research has shown that cessation is associated with QOL benefits. Elements of smoking cessation interventions, such as exercise, may contribute to changes in QOL. However, it is unknown whether initiating exercise in the context of smoking cessation is associated with greater or different effects on QOL than smoking cessation alone. The current study is a secondary analysis of data from a randomized trial (n = 61) of an exercise intervention for smoking cessation. We hypothesized that smoking abstinence and engagement in exercise would have positive, additive effects on QOL at end-of-treatment, 6- and, 12-month follow-ups. Sedentary adult smokers were randomized to the exercise intervention or a health education control (HEC) group. Additionally, all participants received smoking cessation counseling and nicotine patches. Data were analyzed using actual engagement in exercise, rather than group assignment as a proxy for exercise engagement, because some HEC participants also began exercising. Abstinence was positively associated with higher total and physical health QOL at follow-up. Exercise was not associated with total QOL and only marginally associated with physical health QOL, but was positively related to overall sense of well-being. Emphasizing that smoking cessation is associated with higher QOL may help motivate smokers to initiate quit attempts.     

自动化信任和依赖对航空安全的危害及其改进

自动化系统在现今航空业中得到了广泛应用,然而复杂的自动化系统的引入产生了新的失误模式,使航空人因安全问题变得更加突出。受多种因素影响,操作者在与自动化系统的交互过程中并不总能达到适度的信任校准水平。非适度自动化信任和依赖引发了严重的航空安全事故。值得欣慰的是,以人为中心的自动化显示设计和训练能够将非适度自动化信任和依赖调整到适度状态。     

背景性渴求与事件性渴求:区分心理渴求对尼古丁成瘾的不同作用路径

大量研究发现心理渴求机制的紊乱是尼古丁成瘾的核心机制之一。线索暴露是探索心理渴求与尼古丁成瘾关系的重要研究范式。但最近研究者提出该范式较难区分事件性渴求与背景性渴求,导致无法清楚定位渴求在尼古丁成瘾中扮演的角色。通过对以往文献的回顾,对不同成瘾概念、作用机制和生理基础进行对比分析,认为事件性渴求与背景性渴求两者在维持成瘾行为上的确存在不同的作用路径。未来研究应改进实验范式,分别探讨两种心理渴求与尼古丁成瘾的内在联系,完善心理渴求与尼古丁成瘾的关系模型,为尼古丁成瘾的治疗和干预等方法提供一定的理论依据。     

The effect of stress on craving for methadone depends on the timing of last methadone dose

Background

This study examined the extent to which the timing of last methadone dose moderates the influence of a laboratory stressor on craving for methadone in a sample of methadone maintenance patients.

Methods

Methadone maintenance patients (N = 41) completed a computerized stress manipulation with two levels (low and high stress) on two separate days: (1) immediately following the administration of their standard daily methadone dose and (2) immediately prior to receiving their standard daily dose. The impact of stress, timing of methadone dose and their interaction were examined on self-report measures of stress and craving for methadone.

Results

Craving ratings varied according to the timing of last methadone dose. Immediately following methadone dose (i.e., day 1), there was no effect for stress on craving (0.12; p = 0.30). However, prior to receiving methadone dose (i.e., day 2), the high stress effect on craving was significant (1.51; p < 0.001).

Discussion

The present findings indicate that patients currently receiving methadone maintenance treatment may be particularly vulnerable to stress-related relapse immediately prior to daily methadone dosing.     

基于预期理论的参照依赖

参照依赖是指个体基于某一参照点对得失价值进行判断:参照点之上,个体感受为收益,反之即为损失.参照依赖现象广泛存在于生活中的各种领域.当前,对参照依赖心理机制的解释主要有预期理论、后悔理论和三阶段参照点理论.参照依赖的影响因素主要包括经验、情绪状态、文化、目标和认知对象的特点等.未来的研究应主要集中于参照依赖的产生根源,深入探讨参照依赖的神经机制,加强动态参照点、多重参照点以及群体中参照依赖现象的研究.     

THE RELIGIOUS ETHICS IMPLICIT IN SCHLEIERMACHER'S DOCTRINE OF CREATION

There is a religious ethics implicit in Schleiermacher's doctrine of creation based on the universal feeling of absolute dependence “prior to” its being informed by any historical tradition. The “highest good” which fundamentally characterizes his religious ethics is found at the intersection of God and the World. The “original perfection of man” and the “original perfection of the world” come together when human life in the world is fully informed by the feeling of absolute dependence. Although Schleiermacher did not develop his religious ethics to the same extent as his philosophical and Christian ethics, it should still be of interest to ethicists in many religious traditions, as it establishes contours and sets limits for the ethics of any monotheistic religious tradition.     

Winnicott’s foundation for the basic concepts of Freud’s metapsychology?1

In a recent paper, Fulgencio shows how Winnicott rejected the basic speculative concepts of Freud’s metapsychology – Trieb, psychical apparatus and libido – and replaced them with non-speculative concepts that promoted a factual theorization. In this paper, the author examines some of Winnicott’s concepts and attempts to demonstrate how, rather than replacing Freud’s concepts, he provides a factual foundation for the metapsychology in the double dependence of the infant in care. Freud never actually disregards the necessity of early mothering but he takes it for granted. By differentiating between ego needs and id needs, ego-relatedness and id-relatedness, object-mother and environment-mother, Winnicott attempts to theorize what Freud takes for granted: the function of the holding environment as a framework for id-experiences and the function of object-presenting as a condition of reality-testing. Furthermore, by differentiating between pure male and pure female elements, he is also able to construct a highly speculative theorization in order to distinguish two basic principles: doing and being. Although the death drive is clearly rejected, this rejection follows from his theorization of double dependence. Consequently, the author suggests that Winnicott did not discard metapsychological concepts but theorized the conditions for using both these and the intrapsychic topography.     

RESPONSE‐DEPENDENCE THEORY AND EMPIRICAL CLAIMS FOR THE SOCIAL SCIENCES

Abstract: The analysis here is an attempt to show how the current epistemological theory of response‐dependence (R‐D) may be relevant to understanding putative ontological claims of the empirical social sciences. To this end I argue that the constitutive features of human response, central to R‐D theory, can be made explicit for social science. I conclude that for the empirical social sciences the implication of combining R‐D and certain forms of statistical analyses leads to the possibility of an events‐based ontology.