口服药物服药时辰学的探讨

药物口服是临床常用的给药途径。口服药的服用时间有餐前、餐时、餐后、睡前等几种类型。药物的服药时间是根据每种药物的药效学、药动学的不同及药物与食物的关系等多种因素决定的。根据人体生物节律与时展药理学的关系,参考说明书和药学参考书,总结了门诊常用口服药的服用时间,并指出了各种服药时间的优缺点。     

Self in time and language

Time has been considered a crucial factor in distinguishing between two levels of self-awareness: the “core,” or “minimal self,” and the “extended,” or “narrative self.” Herein, I focus on this last concept of the self and, in particular, on the relationship between the narrative self and language. In opposition to the claim that the narrative self is a linguistic construction, my idea is that it is created by the functioning of mental time travel, that is, the faculty of human beings to project themselves mentally backwards in time to relive, or forward to anticipate, events. Moreover, I propose that narrative language itself should be considered a product of a core brain network that includes mechanisms, such as mental time travel, mindreading, and visuo-spatial systems.     

“时间窗”—— 认知加工的后勤基础

时间加工是认知加工的内在属性。因此, 理解发生在知觉或更广泛的认知过程中的时间加工极为重要。为了应对中枢信息加工所面临的外部挑战, 大脑显然已形成了一些用于整合信息的特殊时间窗。已经发现, 其中一个时间窗介于数十毫秒的范围内, 它用于为意识活动产生必要的建构单元。来自反应时、时序阈限以及神经元结构振荡反应的研究为该时间窗的存在提供了实证证据。另一个时间窗的作用范围是2~3秒, 它用于产生“主观现在感”或作为使知觉体的标识保持不变的时间整合区间。支持该窗口存在的实验证据来自时距再现、两可图形、感觉运动同步以及神经生理学研究。还有一种时间窗以昼夜节律的形式存在。所有的心理和生理功能似乎都有着24小时的周期性变化。时间窗的紊乱会以神经或精神疾病的形式表现出来, 这恰恰表明了在基础研究之外对时间加工进行研究的重要性。     

大学生时间管理倾向的测量及与文化取向的关系

依据时间管理的相关理论,参照国内外已有的相关问卷和量表,提出时间管理问卷的结构。对872份有效数据进行探索性和验证性因素分析,同时考察了价值观与时间管理的关系。研究结果表明：（1）大学生时间管理倾向问卷包括6个因子：即规划性、拖延性、时间透视性、自觉控制性、混乱倾向性和抗压性;（2）问卷的内部一致性信度、分半信度和重测信度均较高,问卷具有良好的信效度;（3）价值观中的垂直个人主义对时间管理倾向中的计划性、自觉控制性和混乱倾向性有显著预测作用;价值观中的垂直集体主义对时间透视和抗压力有显著的正向预测作用。     

Unilateral implicit motor learning deficit in developmental dyslexia

It has been suggested that developmental dyslexia involves various literacy, sensory, motor skill, and processing speed deficits. Some recent studies have shown that individuals with developmental dyslexia exhibit implicit motor learning deficits, which may be related to cerebellar functioning. However, previous studies on implicit motor learning in developmental dyslexics have produced conflicting results. Findings from cerebellar lesion patients have shown that patients' implicit motor learning performance varied when different hands were used to complete tasks. This suggests that dyslexia may have different effects on implicit motor learning between the two hands if cerebellar dysfunction is involved. To specify this question, we used a one-handed version of a serial reaction time task to compare the performance of 27 Chinese children with developmental dyslexics with another 27 age-matched children without reading difficulties. All the subjects were students from two primary schools, Grades 4 to 6. The results showed that children with developmental dyslexic responded more slowly than nondyslexic children, and exhibited no implicit motor learning in the condition of left-hand response. In contrast, there was no significant difference in reaction time between two groups of children when they used the right hand to respond. This finding indicates that children with developmental dyslexia exhibited normal motor skill and implicit motor learning ability provided the right hand was used. Taken together, these results suggested that Chinese children with developmental dyslexia exhibit unilateral deficits in motor skill and implicit motor learning in the left hand. Our findings lend partial support to the cerebellar deficit theory of developmental dyslexia.     

Dynamics of psychoanalytic supervision: a heuristic model

This paper presents a heuristic model for the dynamics of psychoanalytic supervision. It is not a manual for how to perform supervision, but a model for how to identify and think about the complex elements and forces influencing the supervisory process. The point of departure is that psychoanalysis is a composite craft in which seemingly contrary elements like strict rules and creative intuitions have their place and interact. Several aspects of supervision are discussed: aims, learning processes, teaching methods, relationship, emotional atmosphere and evaluation. Competence is given a pivotal place in the model. The main feature of the model is that these aspects of supervision are all seen as suspended in a field of dynamic tensions between phenomena in real or apparent opposition. One example of this is the tension in the supervisory relationship between supervisor as instructor acting as an authority for the candidate whilst being a mentor fostering autonomy in the candidate. It is argued that related kinds of dynamics characterize several aspects of psychoanalytic supervision and that these tensions are inherent in analytic work. In conclusion a key word picture of the model is presented.     

Nice Guys Finish Fast and Bad Guys Finish Last: Facilitatory vs. Inhibitory Interaction in Parallel Systems

Systems Factorial Technology is a powerful framework for investigating the fundamental properties of human information processing such as architecture (i.e., serial or parallel processing) and capacity (how processing efficiency is affected by increased workload). The Survivor Interaction Contrast (SIC) and the Capacity Coefficient are effective measures in determining these underlying properties, based on response-time data. Each of the different architectures, under the assumption of independent processing, predicts a specific form of the SIC along with some range of capacity. In this study, we explored SIC predictions of discrete-state (Markov process) and continuous-state (Linear Dynamic) models that allow for certain types of cross-channel interaction. The interaction can be facilitatory or inhibitory: one channel can either facilitate, or slow down processing in its counterpart. Despite the relative generality of these models, the combination of the architecture oriented plus the capacity oriented analyses provide for precise identification of the underlying system.     

Decreased load on general motor preparation and visual-working memory while preparing familiar as compared to unfamiliar movement sequences

Learning movement sequences is thought to develop from an initial controlled attentive phase to a more automatic inattentive phase. Furthermore, execution of sequences becomes faster with practice, which may result from changes at a general motor processing level rather than at an effector specific motor processing level. In the current study, we examined whether these changes are already present during preparation. Fixed series of six keypresses, either familiar or unfamiliar, had to be prepared and executed/withheld after a go/nogo signal. Reaction time results confirmed that familiar sequences were executed faster than unfamiliar sequences. Results derived from the electroencephalogram showed a decreased demand on general motor preparation and visual-working memory before familiar sequences as compared to unfamiliar sequences. We propose that with familiar sequences the presetting segments of responses is less demanding than with unfamiliar sequences, as familiar sequences can be regarded as less complex than unfamiliar sequences. Finally, the decreasing demand on visual-working memory before familiar sequences suggests that sequence learning indeed develops from an attentive to an automatic phase.     

Early electro-cortical correlates of inspection time task performance

The concept of general intelligence (g) summarizes the well established finding that scores on separate cognitive tasks are positively correlated, indicating a trait common to many aspects of information processing. Inspection time is a well-established correlate of IQ, where those of a higher IQ can correctly identify a briefly presented stimulus with a greater level of accuracy than those of a lower IQ. This study used two age-matched samples, selected on the basis of their scores on Raven's Advanced Progressive Matrices from the undergraduate population of Bangor University. In order to address the confound of inspection time and IQ of previous ITT-ERP research, each participant of the presented study performed an IT task with the same five levels of stimulus duration while undergoing 64-channel EEG recording. The high IQ group made significantly fewer errors at each level of stimulus duration and exhibited a significantly larger N1 response. N1 latency and other ERP components did not distinguish the two IQ groups. Given the specificity of ERP group differences to the N1, the results of the present study suggest that the link between IT performance and g is attributable to individual differences in directing attention to a spatial region.     

On the stability of instability: Optimising the reliability of intra-subject variability of reaction times

While reaction times have been traditionally aggregated using measures of central tendency, interest in higher moments of the reaction time distribution, particularly intra-subject variability (ISV), has grown in recent years. However it is unclear to what extent individual differences in these higher moments are stable across time, reflecting trait-like features. The present study compares the reliability of a number of metrics for higher moments of the reaction time distribution on a battery of speeded tasks, and supplements these analyses with a Monte Carlo analysis of the go no-go task. The reliability of ISV is shown to be dependent on both the metric used and the number of trials used to calculate them. However, when using sufficient trials and appropriate metrics, ISV shows good test-retest and odd-even reliability. This study has important practical implications for the design and analysis of studies into ISV, as well as theoretical importance for the trait concept of ISV.