Pirh2在分化型甲状腺癌中的表达及意义

探讨Pirh2、P53在分化型甲状腺癌(DTC)中的表达及其意义.随机选取湖南省人民医院乳腺甲状腺外科2006.6～2011.6间DTC64例,应用免疫组化法检测癌组织中的Pirh2、P53的表达.并以结节性甲状腺肿等良性甲状腺疾病病例作为对照,分析Pirh2、P53对DTC的可能作用.Pirh2、P53分别在64例DTC中阳性表达为68.8％ (44/64)、28.1％(18/64),而在36例甲状腺良性疾病中阳性表达为25％(9/36)、16.7％(6/36).Pirh2在DTC与良性肿瘤间的表达存在差异显著性(P＜0.001).P53在两者间的表达无差异显著性(P＞0.05).Pirh2表达与P53的表达具有正相关性(r=0.316、P＜0.05).Pirh2在DTC中呈较高表达,而在良性甲状腺疾病中表达率低,Pirh2可能与P53共同调节DTC的发生发展.     

探讨甲状腺结节内钙化对甲状腺癌的临床意义

为探讨甲状腺结节内钙化与甲状腺癌的关系,本文对手术病理证实的145例212个甲状腺钙化结节超声声像图表现进行回顾性分析,按照钙化的大小、形状及位置进行分型,统计癌性结节与非癌结节出现各类钙化的比例。结论为甲状腺良、恶性肿瘤均可出现钙化,位于内部、斑点状、针尖样或砂粒样的微钙化结节往往提示恶性可能。超声检查对诊断甲状腺疾...     

甲状腺癌的诊治原则

甲状腺癌是内分泌系统最常见的恶性肿瘤,它的发病率正逐年增加,其诊断方法包括体格检查、超声检查、细针穿刺、影像学检查及实验室检查等,甲状腺癌的治疗以外科手术为主,对较晚期或远处转移的患者可行综合治疗(I131,放疗,化疗)。总之,甲状腺癌经合理治疗,可获得较好的预后。     

老年甲状腺结节的诊治经验

介绍笔者及科室老年甲状腺结节的诊治经验,对2003年1月至2009年12月期间共收治的144例年龄大于60岁的老年甲状腺结节患者进行分析和总结。老年甲状腺结节以多发为主;压迫症状、异物和不适感、继发性甲状腺功能亢进是老年甲状腺结节患者主要的手术指证;术中发现喉返神经和甲状旁腺有脂肪沉着;病理方面良性结节的钙化率较高;患者术后切口水肿比较明显;暂时性低钙血症的发生率较高;虽然术前麻醉ASA评分较低,但术后心肺并发症的发生率并未上升。老年甲状腺结节患者以全麻为宜,最好采用双甲近全切除术,这不仅可避免术后复发和再次手术率,更可减少甲状腺素制剂的用量,减少药物副作用。     

Fetal androgens in the early treated adrenogenital syndrome of 46 XX hermaphroditism: Influence on assertive and aggressive types of behavior

Fifteen hermaphroditic females with the adrenogenital syndrome received corrective, androgen-suppressing therapy with cortisone from birth onward. They were studied psychologically in late adolescence and adulthood, with particular attention to a possible long-term effect of fetal androgenization on aggressive manifestations. No such effect was evident. The girls were tomboyish in the manner previously reported for the adrenogenital syndrome.     

The effects of urine on aggressive responses by male golden hamsters

Twenty adult male golden hamsters were isolated into individual cages for a period of six weeks, at the end of which time they had introduced into their home cages, on three occasions, a castrated male intruder. On each occasion the castrated intruder was daubed on the anogenital region with urine from one of three sources: (1) intact females, (2) other castrated males, and (3) intact males. Urine from a different source was applied to the castrated intruder on each of the three tests. Resident males consistently showed more aggression, sniffing, and following and less defensive behavior than the intruders. However, aggression by the resident males showed a significant variance over the three urine treatments given to the intruder. It is concluded that like male mouse urine, male hamster urine contains attack-provoking cues, but that unlike that of the mouse, female urine does not appear to be attack-inhibiting in this species.     

Thyroid hormones,psychophysiological reactivity,and anxiety

Thirty-eight adults were assigned to three groups: posttreatment hyperthyroid (n=13), low euthyroid (n=12), and high euthyroid (n=13). Physiological and subjective responses to three anxiety-induction procedures—public speaking, personally distressing imagery, and threat of shock—were compared across groups. Although there were differences across stressors for physiological and subjective measures, group differences were not detected. Results are discussed with regard to the risk for residual anxiety following treatment for hyperthyroidism and the possible influence of thyroid function on the etiology or maintenance of anxiety.     

Cowden Syndrome

Cowden syndrome is an autosomal dominant inherited cancer syndrome characterized by multiple hamartomas which may develop in any organ. Mucocutaneous papillomas and trichilemmomas are hallmarks of the syndrome. Affected individuals are at high risk of developing both benign and malignant disease of the thyroid and breast. Epithelial thyroid carcinoma occurs in 3–10% of affected individuals while women have a 25–50% lifetime risk of developing adenocarcinoma of the breast. Because of the cancer risk, it is imperative that health care providers recognize Cowden syndrome. The susceptibility gene has been localized to 10q22-23 and preliminary studies demonstrate no genetic heterogeneity.     

原发性肾病综合征合并甲状腺功能异常患者临床资料分析

分析原发性肾病综合征合并甲状腺功能异常患者的临床特征,探讨其,I盏床意义。对37例原发性肾病综合征合并甲状腺功能异常患者的,陆床资料进行回顾性分析,治疗前检测甲状腺过氧化物酶抗体（Anti～TPO）、甲状腺球蛋白抗体（Anti—TG）,并分别于治疗前后检测血清游离T3（FT3）、血清游离甲状腺激素（FT4）、促甲状腺激...