Stability of heartbeat interval distributions in chronic high altitude hypoxia

Recent studies of nonlinear dynamics of the long-term variability of heart rate have identified nontrivial long-range correlations and scale-invariant power-law characteristics (1/f noise) that were remarkably consistent between individuals and were unrelated to external or environmental stimuli (Meyer et al., 1998a). The present analysis of complex nonstationary heartbeat patterns is based on the sequential application of the wavelet transform for elimination of local polynomial nonstationary behavior and an analytic signal approach by use of the Hilbert transform (Cumulative Variation Amplitude Analysis). The effects of chronic high altitude hypoxia on the distributions and scaling functions of cardiac intervals over 24 hr epochs and 4 hr day/nighttime subepochs were determined from serial heartbeat interval time series of digitized 24 hr ambulatory ECGs recorded in 9 healthy subjects (mean age 34 yrs) at sea level and during a sojourn at high altitude (5,050 m) for 34 days (Ev-K2-CNR Pyramid Laboratory, Sagarmatha National Park, Nepal). The results suggest that there exists a hidden, potentially universal, common structure in the heterogeneous time series. A common scaling function with a stable Gamma distribution defines the probability density of the amplitudes of the fluctuations in the heartbeat interval time series of individual subjects. The appropriately rescaled distributions of normal subjects at sea level demonstrated stable Gamma scaling consistent with a single scaled plot (data collapse). Longitudinal assessment of the rescaled distributions of the 24 hr recordings of individual subjects showed that the stability of the distributions was unaffected by the subject’s exposure to a hypobaric (hypoxic) environment. The rescaled distributions of 4 hr subepochs showed similar scaling behavior with a stable Gamma distribution indicating that the common structure was unequivocally applicable to both day and night phases and, furthermore, did not undergo systematic changes in response to high altitude. In contrast, a single function stable over a wide range of time scales was not observed in patients with congestive heart failure or patients after cardiac transplantation. The functional form of the scaling in normal subjects would seem to be attributable to the underlying nonlinear dynamics of cardiac control. The results suggest that the observed Gamma scaling of the distributions in healthy subjects constitutes an intrinsic dynamical property of normal heart function that would not undergo early readjustment or late acclimatization to extrinsic environmental physiological stress, e.g., chronic hypoxia.     

The momentum of compliance

Compliance with demanding requests that are normally ineffective may be increased by presenting a series of easy or high-probability (high-p) requests before the more demanding requests. Mace and his colleagues have discussed the effectiveness of the high-p procedure in relation to behavioral momentum—the tendency for behavior, once initiated and reinforced, to persist in the face of a challenge. The high-p procedure differs in several ways from that employed in laboratory research on momentum, and the methods and findings of basic research may not be relevant to applied work on compliance. This article reviews some laboratory procedures used in research on behavioral momentum, summarizes the major findings of that research, and discusses its relevance to the high-p procedure and its outcomes. Increased compliance with demanding requests following the high-p procedure can be understood in relation to the procedures and findings of basic research, but some questions arise in the process of translating research into application via the metaphor of momentum. These questions suggest some new directions for both experimental and applied behavior analysis.     

Response-dependent prechoice effects on foraging-related choice

Three experiments explored the influence of prechoice events on pigeons' preference. In two of three studies, a fixed-interval 200-second prechoice period preceded the initial links of a concurrent chain in which outcomes differed either (a) in terms of the delay to food or (b) in terms of amount of food and delay to food. In Experiment 3, the prechoice period preceded the initial links that provided a choice between a small single food presentation and two identical, more delayed food presentations. In all three cases, obtained choice proportions did not vary as a function of prechoice duration. These results suggest that a local-contextual view adequately describes the foraging context; they also have implications for the appropriate formulation of the delay-reduction theory of conditioned reinforcement and rate-maximizing views of optimal foraging theory.     

Assessing preference for reinforcers using demand curves, work-rate functions, and expansion paths

Much research has focused on the effects of environmental variability on foraging decisions. However, the general pattern of preference for variability in delay to reward and aversion to variability in amount of reward remains unexplained a either a mechanistic or a functional level. Starlings' preferences between a fixed and a variable option were studied in two treatments, A and D. The fixed option was the same in both treatments (20-s fixed-interval delay, five units food). In Treatment A the variable option gave two equiprobable amounts of food (20-s delay, three or seven units) and in D it gave two equiprobable delays to food (2.5-s or 60.5-s delays, five units). In both treatments the programmed ratio [amount/(intertrial interval+latency+delay)] in the fixed option equaled the arithmetic mean of the two possible ratios in the variable option (ITI = 40 s, latency = 1 s). The variable option was strongly preferred in Treatment D and was weakly avoided in Treatment A. These results are discussed in the light of two theoretical models, a form of constrained rate maximization and a version of scalar expectancy theory. The latter accommodates more of the data and is based on independently verifiable assumptions, including Weber's law.     

ALTERNATIVE REINFORCEMENT INCREASES RESISTANCE TO CHANGE: PAVLOVIAN OR OPERANT CONTINGENCIES?

Two multiple-schedule experiments with pigeons examined the effect of adding food reinforcement from an alternative source on the resistance of the reinforced response (target response) to the decremental effects of satiation and extinction. In Experiment 1, key pecks were reinforced by food in two components according to variable-interval schedules and, in some conditions, food was delivered according to variable-time schedules in one of the components. The rate of key pecking in a component was negatively related to the proportion of reinforcers from the alternative (variable-time) source. Resistance to satiation and extinction, in contrast, was positively related to the overall rate of reinforcement in the component. Experiment 2 was conceptually similar except that the alternative reinforcers were contingent on a specific concurrent response. Again, the rate of the target response varied as a function of its relative reinforcement, but its resistance to satiation and extinction varied directly with the overall rate of reinforcement in the component stimulus regardless of its relative reinforcement. Together the results of the two experiments suggest that the relative reinforcement of a response (the operant contingency) determines its rate, whereas the stimulus-reinforcement contingency (a Pavlovian contingency) determines its resistance to change.     

Sensitivity of time allocation to an overall reinforcer rate feedback function in concurrent interval schedules

Six pigeons were trained on concurrent variable-interval schedules in which feedback functions arranged that the overall reinforcer rate either (a) was independent of preference, (b) decreased with increasing absolute preference, or (c) increased with increasing absolute preference. In Experiment 1, the reinforcer rate in an interreinforcement interval was determined by the absolute time-allocation ratio in the previous interval. When arranged reinforcer ratios were varied, there was no evidence of control over preference by overall reinforcer rate. In Experiment 2, the feedback function arranged that reinforcer rates were an inverse function of absolute preference, and window durations were fixed times. In Phase 1, using schedules that provided a four-to-one reinforcer ratio, the window duration was decreased from 20 s to 5 s over four conditions. Then, in Phases 2 and 3, the arranged reinforcer ratios were varied. In Phase 2, the reinforcer rate in the current 5-s time window was determined by preference in the previous 5-s window, and in Phase 3, the window durations were 20 s. Again, there was no indication of control by obtained overall reinforcer rate. These data call into question theories that suggest that the process underlying matching is one of maximizing overall reinforcer rates, or that preference in concurrent aperiodic schedules is controlled to any extent by overall reinforcer rate. They also question the notion that concurrent-schedule preference is controlled by molecular maximizing.     

Discrete and continuous measures of dimensional stimulus control

In two sets of experiments, we examined dimensional stimulus control of pigeons' responses to a visual flicker-rate continuum. In the first experiment, responses to a single key were reinforced periodically during stimuli from one half of the stimulus continuum, and responses during other stimuli were extinguished. In the second experiment, two response keys were simultaneously available, with reinforcement for each response alternative associated with different halves of the stimulus continuum. Conditions of the second experiment involved either free-operant or discrete-trial stimulus presentations. Results from these experiments show that positive dimensional contrast appeared in discrimination tasks with one or two response alternatives, but only with free-operant procedures. In addition, discrimination between stimulus classes established by differential reinforcement was assessed as accurately by continuous rate measures as by discrete response choice in the two-alternative situation. The general implication of these experiments is that response rate measures, when properly applied, may reveal sources of variation within stimulus classes, such as dimensional contrast, that are not evident with discrete measures.     

Chlordiazepoxide effects on ethanol self-administration: dependence on concurrent conditions.

Experiments examined the effects of acute doses of chlordiazepoxide upon ethanol self-administration in the rat. A concurrent-schedule procedure was used that employed choice between ethanol (5%) and a second fluid (either water or a 1% sucrose solution). When ethanol and water were the available fluids, chlordiazepoxide at doses of 15 and 20 mg/kg reduced ethanol-reinforced responding and intake, with a greater reduction occurring at the 20 mg/kg dose. However, when ethanol and sucrose were concurrently available, in many rats only the 20 mg/kg dose of chlordiazepoxide reduced ethanol-reinforced responding. The differences in dose response function occurred in most animals without large changes in the baseline ethanol-reinforced responding across the two concurrent conditions. Thus the dose-effect curve relating chlordiazepoxide and ethanol self-administration can be altered, dependent upon the nature of the concurrently available reinforcers.     

Modality-repetition and attentional effects on reflex blinking in infants and adults

The ability of a brief prepulse to inhibit reflexively elicited startle is a robust phenomenon in adults of several species but is weak or absent in infants. The possibility that afferent processing of the prepulse is inadequate in infants was tested by assessing the integrity of two other types of reflex modulation that occur in modality-specific paths, that is, attenuation by repetition of same-modality stimuli and enhancement by modality-selective attention. The reflex, measured by electromyographic activity of the muscle controlling blink, was elicited by intense light flashes or noise bursts preceded by brief acoustic or visual prepulses and delivered during attention-directing acoustic or visual foregrounds that evoked cardiac deceleration. Modality-repetition effects were evidenced by smaller peak blink magnitude and longer latency of blinking to same than to different modality pairs and did not differ as a function of age (4-month-old infants or college students). Attention effects were also seen in both infants and adults and, in accord with previous findings, were evident in magnitude for infants and latency for adults. Thus, immaturity in paths mediating these effects could not explain delayed development of prepulse inhibition. Other possibilities include delayed maturation of extrinsic inhibition or of transient-processing systems.     

Evaluating the impact of adaptive signal control technology on driver stress and behavior using real-world experimental data

While the operational and crash reduction benefits of adaptive signal control technology (ASCT) have long been investigated, the impact of this technology on driver behavior and stress is still uncertain. This study evaluated the impact of ASCT on driver behavior and stress in a real-world environment. Participants travelled through two arterial corridors, one equipped with ASCT and the other having traditional time-of-day coordinated signals. Driver stress was measured using a heart rate detector and a perceived stress scale while driver behavior was examined using vehicular trajectory data. Overall, driving behavior improved on the ASCT as compared to the non-ASCT corridor, as indicated by higher speeds and a fewer number of stops on the ASCT corridor relative to the non-ASCT corridor. Repeated measures ANOVA showed a statistically significant reduction in driver heart rate by −10 beats per minute over the ASCT corridor. A similar trend was observed for drivers’ perceived stress, analyzed by Wilcoxon sign ranked test. Driving behavior also showed significant improvement with ASCT presence, and speed was found to be negatively correlated with stress. Furthermore, the participants’ speed was controlled by the two systems i.e. ASCT and non-ASCT as expected. This study provides a significant proof of concept that ASCT can create positive improvements in driver stress and behavior that can be further investigated in the future.