骨髓间充质干细胞移植治疗感音神经性聋的进展及评价

目前感音神经性聋缺乏直接有效的药物治疗措施,基因治疗及干细胞移植治疗为临床治疗提供新的思路。骨髓间充质干细胞具有异于其他干细胞的优点,耳蜗内移植后能起到基因治疗的目的,并有潜在的分化为内耳功能细胞的功能,但仍面临诸多尚待解决的问题。     

口腔颌面部鳞状细胞癌的综合序列治疗

口腔颌面部鳞状细胞癌(鳞癌)在头颈部肿瘤的发病和治疗中占有重要地位,综合序列治疗的概念和理论逐渐成为口腔颌面部鳞癌治疗的指导原则。本文对口腔颌面部鳞癌综合序列治疗所包含的手术治疗、放射治疗、化学治疗及生物治疗从临床治疗策略上进行分析、讨论,以期促进口腔颌面部鳞癌综合序列治疗原则在临床获得更好地应用。     

弥漫性大B细胞淋巴瘤预后因素探讨及IgH基因重排检测

为了探讨CD10、bcl-6蛋白表达与弥漫性大B细胞淋巴瘤(DLBCL)预后之间的关系及IgH基因重排检测在其诊断和鉴别诊断中的价值,我们采用免疫组化法观察CD10、bcl-6两种蛋白在DLBCL中的表达,半巢式PCR方法检测IgH基因重排。结果发现CD10、bcl-6蛋白阳性表达率分别为46.9%和65.6%,bcl-6阳性组预后较好。32例DLBCL中基因重排阳性率为78.1%。结论认为CD10、bcl-6蛋白表达与DLBCL预后有一定相关性,可作为判断DLBCL预后的参考指标。IgH基因重排检测在DLBCL疑难病例的诊断和鉴别诊断中有帮助。     

又有一项生物学信条受到挑战

生物学上的一条新发现———终末分化的神经细胞和心肌细胞具有分裂增殖的能力，向传统理论提出了挑战。指出了真理受一定时代和范围的限制，具有相对性，我们不能超越客观事实去片面追求完善的真理，又要敢于在新技术手段的支持下，提出新观点，勇于向传统观念挑战     

Executive performance on the preschool executive task assessment in children with sickle cell anemia and matched controls

Executive deficits are commonly reported in children with sickle cell anemia. Earlier identification of executive deficits would give more scope for intervention, but this cognitive domain has not been routinely investigated due to a lack of age-appropriate tasks normed for preschool children. In particular, information relating to patient performance on an executive task that reflects an everyday activity in the classroom could provide important insight and practical recommendations for the classroom teacher at this key developmental juncture as they enter the academic domain. The performance of 22 children with sickle cell anemia was compared to 24 matched control children on the Preschool Executive Task Assessment. Findings reveal that children with sickle cell anemia are performing poorer than their matched peers on this multi-step assessment. In particular, children with sickle cell anemia required more structured support to shift focus after a completed step, as reflected by poorer scores in the quantitative Sequencing and Completion domains. They also required more support to stay on task, as seen by poorer ratings in the qualitative Distractibility domain.

Abbreviations:PETA: Preschool Executive Task Assessment; SCA: Sickle Cell Anemia; EF: Executive Functioning.     

AN INCLUSIVE ETHICS FOR THE TWENTY-FIRST CENTURY: IMPLICATIONS FOR STEM CELL RESEARCH

An important contribution of Christian ethics in the pluralistic world of the twenty‐first century is to emphasize inclusivity. Rather than promoting the interests of certain groups at the expense of the most vulnerable, society does well to prioritize ways forward that benefit all. For stem cell research, inclusivity entails benefiting or at least protecting the beneficiaries of treatment, the sources of materials, and the subjects of research. Adult stem cells are already benefiting many ill patients without causing harm, and select adult cells may prove even more beneficial in the future. Other types of stem cells require other bodily materials such as eggs and somatic cells that should be obtained without unduly harming those who provide them. Research subjects, especially the most vulnerable, require protection as well. Should human embryos be included among them? Considerations of location, formation, individuation, and intention are here examined. Ultimately, for safety reasons as well as workability, pluripotency, and compatibility, relatively new types of pluripotent stem cells, especially induced pluripotent stem cells, warrant special priority according to an inclusive ethics.