Memory deficits in young schizophrenics with normal general intellectual function

The aim of the present study was to examine different dimensions of memory functioning in young schizophrenics with normal general intellectual abilities. Thirty-three patients with schizophrenia and 33 healthy controls were included in the study. The results suggest that immediate short-term memory is intact, though there emerged a working memory deficit in the schizophrenia group. Deficient encoding of verbal material was observed in some, but not in other, testing conditions. There also seemed to be a retrieval deficit for verbal material in schizophrenia, though no storage deficit was indicated. Impaired memory for non-verbal material was also revealed. These results occurred in a context of intact executive functioning as measured by the Wisconsin Card Sorting Test. The results indicate that temporal and frontal structures, as well as their interconnections, may be compromised in schizophrenia.     

On the Correlation between Synchronized Oscillatory Activities and Consciousness

Recent experiments have shown that the amplitudes of cortical gamma band oscillatory activities that occur during anesthesia are often greater than amplitudes of similar activities that occur without anesthesia. This result is apparently at odds with the hypothesis that synchronized oscillatory activities constitute the neural correlate of consciousness. We argue that while synchronization and oscillatory patterning are necessary conditions for consciousness, they are not sufficient. Based on the results of a binocular rivalry study of Fries et al. (1997), we propose that the degrees of oscillatory strength and synchronization of neuronal activities determine the degree of awareness those activities produce. On the other hand, the overal firing rates of neurons in cortical sensory areas are not correlated with the degree of awareness the activities of those neurons produce. The results of the experiment of Fries et al. (1997) appear to conflict with the results of another binocular rivalry experiment, in which monkeys were trained to pull a lever in order to report which stimulus object was being perceived (Leopold & Logothetis, 1996). In the latter experiment, it was demonstrated that the firing rates of neurons in striate cortex did not change during perceptual alterations, while 90% of neurons in inferior and superior temporal cortices changed their firing rate when the perceived image changed. This result led to the conclusion that activities in temporal cortex are correlated with visual awareness, but those in striate cortex are not. We argue that activities in temporal cortex contribute little, if anything, to perceptual awareness, and that their primary function is computational. Thus the correlation between the firing rates of neurons in these areas and the responses of the monkeys is due to the recognition of a particular stimulus object, which in turn is due to the computations made there.     

Reduced right hemisphere activation in severely abused violent offenders during a working memory task: An fMRI study

This study uses functional magnetic resonance imaging (fMRI) to address two important gaps in our knowledge of brain functioning and violence: (1) What are the brain correlates of adults in the community who have suffered severe physical abuse early in life and who go on to perpetrate serious violence in adulthood? (2) What characterizes those who experience severe physical abuse but who refrain from serious violence? Four groups of participants recruited from the community (controls, severe physical child abuse only, serious violence only, and severely abused, seriously violent offenders) underwent fMRI while performing a visual/verbal working memory task. Violent offenders who had suffered severe child abuse show reduced right hemisphere functioning, particularly in the right temporal cortex. Abused individuals who refrain from serious violence showed relatively lower left, but higher right, activation of the superior temporal gyrus. Abused individuals, irrespective of violence status, showed reduced cortical activation during the working memory task, especially in the left hemisphere. Brain deficits were independent of IQ, history of head injury, task performance, cognitive strategy, and mental activity during the control task. Findings constitute the first fMRI study of brain dysfunction in violent offenders, and indicate that initial right hemisphere dysfunction, when combined with the effects of severe early physical abuse, predisposes to serious violence but that relatively good right hemisphere functioning protects against violence in physically abused children. Aggr. Behav. 27:111–129, 2001. © 2001 Wiley‐Liss, Inc.     

发展性阅读障碍视听时间整合缺陷可能的机制：视听时间再校准能力受损

发展性阅读障碍的本质一直是研究者争论的焦点。大量研究发现,阅读障碍者具有视听时间整合缺陷。然而,这些研究仅考察了阅读障碍者视听时间整合加工的整体表现,也就是平均水平的表现,却对整合加工的变化过程缺乏探讨。视听时间再校准反映了视听时间整合的动态加工过程,对内部时间表征与感觉输入之间差异的再校准困难则会导致多感觉整合受损,而阅读障碍者的再校准相关能力存在缺陷。因此,视听时间再校准能力受损可能是发展性阅读障碍视听时间整合缺陷的根本原因。未来的研究需要进一步考察发展性阅读障碍者视听时间再校准能力的具体表现,以及这些表现背后的认知神经机制。     

孤独症谱系障碍者的生物运动探测障碍：基于行为与神经的证据

关于孤独症谱系障碍个体探测生物运动的能力是否受损,已有行为研究尚存分歧。导致分歧的原因可能是实验刺激、实验任务和测量指标存在差异。然而,神经研究却一致证实其潜在的神经机制存在异常。领域特殊性观点认为该障碍可能是基于后侧颞上沟功能异常的社会性功能障碍,也可能是基于镜像神经元功能异常的社会性功能障碍;而领域一般性观点认为该障碍可能是基于背侧视觉流功能异常的视运动知觉障碍,也可能基于脑功能联结异常的弱中央统合障碍。据此,本文将从研究范式、行为表现及潜在机制三个方面梳理相关研究,以期为后续研究提供新方向。     

信息保持、短时存贮与执行控制的脑模型

工作记忆的脑机制是认知神经科学研究的重要问题。研究者在分析大量脑成像研究数据的基础上,创建了许多解释工作记忆神经基础的模型。Smith和Jonides发展了工作记忆成分结构模型和贮存与执行加工分离模型。Postle和D’Esposito建构了工作记忆相对表征混合模型,D’Esposito, Postle和Rypma阐述了工作记忆加工阶段动态模型。Fletcher和Henson提出工作记忆额叶分区整合理论。该文通过对上述模型或理论的评价,总结了工作记忆脑成像研究中存在的问题,展望了该研究领域的发展趋势。     

夫妻沟通模式与婚姻质量的关系

本文拟采用主-客体互倚模型(Actor-partner interdependence model,APIM)的方法深入探讨夫妻双方感知到的夫妻间的沟通模式与其自身及配偶感知到的婚姻质量之间的关系。以方便取样的方式在澳门地区选取130对成年夫妻,采用Christensen等人修订的沟通模式调查问卷(Communication Pattern Questionnaire,CPQ)和Spanier编制的婚姻质量问卷(Dyadic Adjustment Scales,DAS),要求夫妻双方分别以自陈问卷的方式报告其感知到的沟通模式和婚姻质量。通过配对t检验、相关分析和结构方程模型统计分析发现:(1)夫妻间的沟通以建设性沟通为主,双方回避和要求/回避型沟通较少;丈夫感知到的婚姻质量总体上优于妻子感知到的婚姻质量。(2)夫妻双方在沟通模式和婚姻质量的感知上具有一致性,在沟通模式中的两个和婚姻质量中的三个分量表上的得分不存在显著差异。(3)夫妻间建设性沟通可以显著地正向预测自身感知到的婚姻质量;而双方回避和要求/回避型沟通则显著地负向预测自身感知到的婚姻质量。(4)在控制了丈夫、妻子感知到的沟通模式对其自身婚姻质量的主体效应之后,丈夫感知到的沟通模式可以显著地预测妻子感受到的婚姻质量;然而妻子感知到的沟通模式并不能显著地预测丈夫的婚姻质量。     

时间贴现的性质与脑机制

时间贴现是指个人对事件的价值量估计随着时间的流逝而下降的心理现象,它是行为选择理论的一个重要组成部分。着重介绍了时间贴现的数学模型（指数模型、双曲线模型族、非双曲线模型）、时间贴现现象和概率贴现现象的联系、延迟兑现与提前兑现时间贴现不对称现象及其理论解释,还讨论了时间贴现现象的神经机制研究。提出了时间贴现未来研究的几个主要问题     

时间距离对于验证性信息加工的影响

研究基于解释水平理论考察时间距离对于验证性信息加工的影响, 即在个体和组织决策情境中, 人们倾向于偏好选择和高估与自身观点和决策相一致的信息, 而不是非一致性信息。通过4个情境决策实验, 研究结果一致表明近期决策会提高信息搜寻和评估中的验证偏差, 而远期决策会降低它们的验证偏差, 知觉到的决策确定性在其中起到部分中介作用(实验1b)。解释水平(实验2)和期许性/可行性表征(实验3)分别在时间距离对验证性信息加工的影响中起到调节作用, 结果依次表明在低解释水平(高可行性-低期许性特征)条件下, 时间距离与验证性信息加工的负相关关系会得到显著增强, 而在高解释水平(高期许性-低可行性特征)条件下, 时间距离与验证性信息加工的负相关关系会得到显著降低。     

回避与趋近性负性人格特质对应激心血管反应模式的不同影响

本研究考察了回避与趋近性负性特质对不同强度心理社会应激刺激重复暴露的心血管反应、应激后心血管反应恢复、重复应激心血管反应的影响,并探讨了应激认知评价在其中的作用。167名大学生被试被随机分配到中/高强度应激条件中,连续采集其在基线期、首次应激期、恢复期、重复应激期四个阶段的心血管反应数据。结果发现:(1)无论应激强度如何,回避性负性特质预测首次和重复应激中较低(钝化)的心血管反应和应激后较差的恢复,而趋近性负性特质预测较大的心血管反应和应激后较差的恢复。(2)重复应激个人资源感知在回避性负性特质与重复应激心率反应之间起中介作用。因此,回避性负性特质与持续较低(钝化)的应激心血管反应和应激后较差的恢复相联系,而趋近性负性特质与较大的应激心血管反应和应激后较差的恢复相联系,即两类负性特质均表现出不适应的固化的应激心血管反应模式,这可能构成了两类不同负性特质增加罹患心血管疾病风险的生理机制。