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991.
Castiblanco-Piñeros E Quiroz-Padilla MF Cardenas-Palacio CA Cardenas FP 《Neurobiology of learning and memory》2011,96(2):272-279
The parafascicular (PF) nucleus, a posterior component of the intralaminar nuclei of the thalamus, is considered to be an essential structure in the feedback systems of basal ganglia–thalamo-cortical circuits critically involved in cognitive processes. The specific role played by multimodal information encoded in PF neurons in learning and memory processes is still unclear. We conducted two experiments to investigate the role of the PF in the spontaneous object recognition (SOR) task. The behavioral effects of pretraining rats with bilateral lesions of PF with N-methyl-D-aspartate (NMDA) were compared to vehicle controls. In the first experiment, rats were tested on their ability to remember the association immediately after training trials and in the second experiment after a 24 h delay. Our findings provide evidence that PF lesions critically affect both SOR tests and support its role in that non-spatial form of relational memory. 相似文献
992.
de Bruin NM Prickaerts J van Loevezijn A Venhorst J de Groote L Houba P Reneerkens O Akkerman S Kruse CG 《Neurobiology of learning and memory》2011,96(2):392-402
The 5-hydroxytryptamine6 (5-HT6) receptor has been suggested to play an important role in the regulation of memory and cognition. In the present study, our aim was to investigate whether the novel, selective 5-HT6 antagonists compound (CMP) X and CMP Y and the reference 5-HT6 antagonist GSK-742457 could ameliorate impairments in episodic memory in 3-months-old male Wistar rats. The acetylcholinesterase inhibitor (AChEI) donepezil (Aricept®, approved for symptomatic treatment of Alzheimer’s disease, AD) was used as a positive reference compound. First, effects of the 5-HT6 antagonists CMP X, CMP Y and GSK-742457 were investigated on object recognition task (ORT) performance in rats treated with the muscarinic antagonist scopolamine (0.1 mg/kg, administered intraperitoneally, i.p., 30 min before trial 1). Second, effects of the combination of suboptimal doses of 5-HT6 antagonists CMP X and CMP Y with the AChEI donepezil were studied, to determine whether the 5-HT6 antagonists show additive synergism with donepezil in the ORT. Finally, effects of CMP Y, GSK-742457 and donepezil were investigated on object location task (OLT) performance in rats treated with scopolamine.Donepezil (1 mg/kg, oral administration, p.o.), GSK-742457 (3 mg/kg, i.p.), CMP X (3 mg/kg, i.p.) and CMP Y (30 mg/kg, p.o.), all ameliorated the scopolamine-induced deficits in object recognition. In the ORT, we have found that combined administration of subthreshold doses of CMP X (1 mg/kg, i.p.) and CMP Y (10 mg/kg, p.o.) with the AChEI donepezil (0.1 mg/kg, p.o.), enhanced memory performance in Wistar rats with deficits induced by scopolamine. Donepezil (0.1 mg/kg, p.o.) alone had no discernable effects on performance. This suggests additive synergistic effects of the 5-HT6 antagonists (CMP X and CMP Y) with donepezil on cognitive impairment. Finally, donepezil (1 mg/kg, p.o.), GSK-742457 (10 mg/kg, p.o.) and CMP Y (30 mg/kg, p.o.) also reduced scopolamine-induced deficits in the OLT.In conclusion, the 5-HT6 antagonists were found to clearly improve episodic memory deficits induced by scopolamine. In addition, co-administration of the 5-HT6 receptor antagonists CMP X and CMP Y with the AChEI donepezil to cognitively impaired rats also resulted in potentially additive enhancing effects on cognition. This suggests that these compounds could have potential as monotherapy, but also as adjunctive therapy in patients with AD treated with common treatments such as donepezil. 相似文献
993.
Nadja Schömig Barbara Metz Hans-Peter Krüger 《Transportation Research Part F: Traffic Psychology and Behaviour》2011,14(6):525-538
The paper describes an experiment where anticipatory processes in the interaction with secondary tasks while driving could be explicitly identified and contrasted to control processes during the engagement in the secondary task. A special experimental set-up in a driving simulator environment was created that allows drivers to deliberately decide whether they want to be distracted or not depending on the driving situation and the expected development of that situation. As indicators for a situation-adaptive interaction with secondary tasks parameters from driving behaviour, secondary task performance and visual behaviour were analyzed. A study with 24 test drivers revealed that drivers are, in general, able to interact with a secondary task in a situation-aware manner. For example, drivers rejected more secondary tasks in already highly demanding situations or tried to delay the beginning of the task. During secondary task performance drivers observed the situational development with short control glances back to the road and adapted their speed. The analysis of driving errors revealed that rejecting a task in an already highly demanding driving situation is an effective strategy to maintain an adequate level of driving safety. However, some critical factors were identified that might hinder the driver from executing such strategies. Several recommendations for supporting the driver on this issue are given. 相似文献
994.
时间加工是认知加工的内在属性。因此, 理解发生在知觉或更广泛的认知过程中的时间加工极为重要。为了应对中枢信息加工所面临的外部挑战, 大脑显然已形成了一些用于整合信息的特殊时间窗。已经发现, 其中一个时间窗介于数十毫秒的范围内, 它用于为意识活动产生必要的建构单元。来自反应时、时序阈限以及神经元结构振荡反应的研究为该时间窗的存在提供了实证证据。另一个时间窗的作用范围是2~3秒, 它用于产生“主观现在感”或作为使知觉体的标识保持不变的时间整合区间。支持该窗口存在的实验证据来自时距再现、两可图形、感觉运动同步以及神经生理学研究。还有一种时间窗以昼夜节律的形式存在。所有的心理和生理功能似乎都有着24小时的周期性变化。时间窗的紊乱会以神经或精神疾病的形式表现出来, 这恰恰表明了在基础研究之外对时间加工进行研究的重要性。 相似文献
995.
摘 要:目的 探讨高特质愤怒个体是否对负性情绪面孔有注意偏向。方法 采用点探测任务,比较高低特质愤怒个体(高特质愤怒组23人,低特质愤怒组23人)对不同性质情绪面孔同异侧探测符号反应时的差异。结果 重复测量方差分析发现存在面孔性质边缘主效应(F=2.462,p=.073)及组别与面孔性质的交互效应,探测位置主效应(F=5.089,p=.029)及组别与探测位置的交互效应,组别、面孔性质与探测位置的交互效应。进一步分析发现,高特质愤怒组对愤怒面孔同侧探测刺激反应时显著快于异侧反应时[(386.12±50.09)ms VS.(403.33±59.39)ms,F=17.050,p=.000],快乐面孔同侧探测刺激反应时显著慢于异侧反应时[(396.88±53.87)ms VS.(38.78±41.06)ms,F=18.200,p=.000)],低特质愤怒组被试不同性质面孔同异侧反应时无显著差异。结论 高特质愤怒个体对与愤怒相关刺激存在注意偏向。 相似文献
996.
It has been suggested that developmental dyslexia involves various literacy, sensory, motor skill, and processing speed deficits. Some recent studies have shown that individuals with developmental dyslexia exhibit implicit motor learning deficits, which may be related to cerebellar functioning. However, previous studies on implicit motor learning in developmental dyslexics have produced conflicting results. Findings from cerebellar lesion patients have shown that patients' implicit motor learning performance varied when different hands were used to complete tasks. This suggests that dyslexia may have different effects on implicit motor learning between the two hands if cerebellar dysfunction is involved. To specify this question, we used a one-handed version of a serial reaction time task to compare the performance of 27 Chinese children with developmental dyslexics with another 27 age-matched children without reading difficulties. All the subjects were students from two primary schools, Grades 4 to 6. The results showed that children with developmental dyslexic responded more slowly than nondyslexic children, and exhibited no implicit motor learning in the condition of left-hand response. In contrast, there was no significant difference in reaction time between two groups of children when they used the right hand to respond. This finding indicates that children with developmental dyslexia exhibited normal motor skill and implicit motor learning ability provided the right hand was used. Taken together, these results suggested that Chinese children with developmental dyslexia exhibit unilateral deficits in motor skill and implicit motor learning in the left hand. Our findings lend partial support to the cerebellar deficit theory of developmental dyslexia. 相似文献
997.
This study investigates how the maternal level of perspectivistic reasoning and the level of socialization goals in the representation of their actions are related to the quality of mother-child behaviors as well as to the expert ratings on maternal practices in at-risk contexts. It also investigated whether there is any direct link between mother and child behaviors and expert ratings. A sample of 75 mothers of children between 8 and 12 years old reported on their level of perspectivistic reasoning and were characterized by the social workers of municipal services as being coercive, neglectful or meeting their child's needs. Interactions during a collaborative task were observed to obtain information on level of socialization goals and mother-child behaviors. Structural equation models showed that mothers' higher levels of perspectivism and higher levels of socialization goals positively predicted the mother's and child's sensitivity and active involvement in the task and negatively predicted avoidance and passivity. Higher levels of perspectivism consistently predicted experts' views on maternal practices. However, only mother's avoidance predicted negatively expert ratings on coercion practice, indicating that expert views were mostly derived from the mothers' perspective on their child. The implications of these results for parental assessment and intervention programs are discussed. 相似文献
998.
The present study tested diffusion models of processing in the flanker task, in which participants identify a target that is flanked by items that indicate the same (congruent) or opposite response (incongruent). Single- and dual-process flanker models were implemented in a diffusion-model framework and tested against data from experiments that manipulated response bias, speed/accuracy tradeoffs, attentional focus, and stimulus configuration. There was strong mimcry among the models, and each captured the main trends in the data for the standard conditions. However, when more complex conditions were used, a single-process spotlight model captured qualitative and quantitative patterns that the dual-process models could not. Since the single-process model provided the best balance of fit quality and parsimony, the results indicate that processing in the simple versions of the flanker task is better described by gradual rather than discrete narrowing of attention. 相似文献
999.
Previous findings suggest that religion has a specific impact on attentional processes. Here we show that religion also affects action control. Experiment 1 compared Dutch Calvinists and Dutch atheists, matched for age, sex, intelligence, education, and cultural and socio-economic background, and Experiment 2 compared Italian Catholics with matched Italian seculars. As expected, Calvinists showed a smaller and Catholics a larger Simon effect than nonbelievers, while performance of the groups was comparable in the Stop-Signal task. This pattern suggests that religions emphasizing individualism or collectivism affects action control in specific ways, presumably by inducing chronic biases towards a more “exclusive” or “inclusive” style of decision-making. Interestingly, there was no evidence that religious practice affects inhibitory skills. 相似文献
1000.
The time taken to decide whether a character is shown in its mirror or normal version has been shown to increase approximately linearly with the angular departure from an up-right position. Additionally, in some studies, decisions took longer for clockwise tilted characters than for counterclockwise tilted ones. Other studies do not report the latter effect. We argue that inconsistencies across studies are caused by variance in participants' strategies. The task employed here was specifically designed to bring these strategies and thereby the direction of rotation under experimental control. From the EEG recorded during the rotation period, we extracted an event-related slow potential whose amplitude is sensitive to the amount of mental rotation. In both strategy conditions, the slow potential's amplitude was lower for clockwise than for counterclockwise rotations. We take this as evidence that mental rotation of alphanumeric characters is easier in a clockwise than in a counterclockwise direction. 相似文献