Reconsidering reconsent: Threats to internal and external validity when participants reconsent after debriefing

We overwhelmingly utilize (partially) informed consent for, and debriefing of, human research participants. Also common is the practice of reconsent, particularly where changes in study protocols (or in participants themselves) occur midstream – participants consent again to remaining in the project or to having their data included. Worryingly under-discussed is post-debriefing reconsent, wherein participants can withdraw their data after learning more fully of the study's goals and methods. Yet, major ethics bodies in Canada, the United States and the United Kingdom promote such practice, with vague and potentially problematic guidelines. Here, the author provides examples involving such reconsent practice, highlighting potentially serious problems that are scientific (e.g. threats to internal and external validity) and ethical (i.e. to the participant, their peers, the researcher and society) in nature. Particularly, problematic is the introduction, by design, of unknowable bias in our research findings. For example, highly prejudiced participants could withdraw data from a discrimination study after learning of the study's hypotheses and goals. The practice may arguably contradict an Open Science goal of increasing research transparency. This call for discussion about the direction of psychological science methods aims to engage a broader discussion in the research community.     

项目特征曲线等值的抽样误差

现在,等值越来越受到各考试测验机构及测量学研究人员的重视,特别是项目反应理论等值的优越性更使他们有了信心。然而,很多人却没有注意到被试能力分布形态可能给等值结果带来的影响效果及程度。本研究以项目反应理论两级记分模型的项目参数等值在不同被试能力分布形态下的结果差异作为重点,探讨被试抽样偏差可能给项目特征曲线等值带来的误差问题。研究结果表明,被试能力分布形态会显著地影响项目参数等值的系数,特别地,能力分布的偏态系数与等值方程的截距存在显著的线性相关关系,但能力分布形态的变化对等值方程中斜率的影响并不明显     

Postural change effects on infants' AB task performance: visual, postural, or spatial?

Smith and colleagues (Smith, L. B., Thelen, E., Titzer, R., & McLin, D. (1999). Knowing in the context of acting: The task dynamics of the A-not-B error. Psychological Review, 106, 235-260) demonstrated that 10-month-olds succeed on a Piagetian AB search task if they are moved from a sitting position to a standing position between A and B trials. These authors explained this result by suggesting that because the reach must be executed by different muscle forces from the standing position, an appropriate reach to B is programmed without the memory of the previous reach interfering with the current reach. In the main study reported here, the influences of postural and spatial factors are separated by adding a condition in which the table containing the hiding wells is moved up at the same time as the infant is shifted to standing, thereby allowing a postural change without a change in the spatial relations between the hand and hiding locations. Results showed that in both a standard control condition and the sitting-to-standing condition in which the table also moved up, performance was poor. Only in the sitting-to-standing condition in which the spatial relation between the hand and apparatus was altered were infants successful. These outcomes demonstrate that perseveration effects are likely to occur at the level of reach planning rather than at the level of execution, thereby narrowing the gap between explanations of improvements in AB performance with age that emphasize prefrontal maturation as opposed to improvements in reaching ability.     

从中药的安全性谈中药产业的危机管理

药物的安全性是药物评价的首要标准。《欧盟传统药品法案》对中药的技术壁垒和我国对某些中药的毒副作用的披露,使得中药的安全性问题日益突出,使得中药产业面临前所未有的危机。对中药安全性的理性认识是扩大其国内市场占有率、走向国际市场所必须突破的瓶颈,也是中药产业危机管理的必由通道。这是一场深刻的文化革命。     

错误相关负波（ERN）在精神病理学研究中的应用

错误相关负波（error-related negativity, ERN）是由行为错误诱发的一种脑电波成分,最大峰值在错误反应之后的50ms左右,偶极子源定位于前扣带回（anterior cingulate cortex, ACC）附近。错误加工（error processing）的经典研究范式中出现的ERN成分可能反映了ACC具有错误检测、冲突监控、强化学习、情绪动机等功能。大量研究表明过度的和不足的错误相关脑活动（hyperactive and hypoactive error processing）可能分别与精神病理学的内化性和外化性障碍（internalizing and externalizing disorders）相关联。内化性和外化性障碍的内表型（endophenotype）的研究,还存在许多值得进一步探索的问题。     

Inexact Knowledge with Introspection

Standard Kripke models are inadequate to model situations of inexact knowledge with introspection, since positive and negative introspection force the relation of epistemic indiscernibility to be transitive and euclidean. Correlatively, Williamson’s margin for error semantics for inexact knowledge invalidates axioms 4 and 5. We present a new semantics for modal logic which is shown to be complete for K45, without constraining the accessibility relation to be transitive or euclidean. The semantics corresponds to a system of modular knowledge, in which iterated modalities and simple modalities are not on a par. We show how the semantics helps to solve Williamson’s luminosity paradox, and argue that it corresponds to an integrated model of perceptual and introspective knowledge that is psychologically more plausible than the one defended by Williamson. We formulate a generalized version of the semantics, called token semantics, in which modalities are iteration-sensitive up to degree n and insensitive beyond n. The multi-agent version of the semantics yields a resource-sensitive logic with implications for the representation of common knowledge in situations of bounded rationality.     

A model of working memory capacity in the radial-arm maze task

The radial arm maze is one of the most commonly used tests for assessing working memory in laboratory animals. However, to date, there exists no quantitative method of estimating working memory capacity from performance on this task. Here, we present a mathematical model of performance on the radial arm maze from which we can derive estimates of capacity. We derive explicit results for the two most commonly used measures of performance as functions of number of arms in the maze and memory capacity, assuming a uniform random search. We simulate random non-uniform search strategies. Comparing our model to previous experiments, we show that our model predicts a working memory capacity in the range of 3-9 at the level of performance observed in these experiments. This estimate is within the typical estimate of human working memory capacity. Performance of rats on large mazes (e.g. 48 arms) has been used as evidence that the working memory capacity of rats may be significantly larger than that of humans. We report that memory capacity in the range 3-9 is sufficient to explain the performance of rats in very large radial mazes. Furthermore, when we simulate non-uniform random search strategies observed in the experiments, the resulting estimates do not differ significantly from those assuming a uniform random search. We conclude that a list-based model of working memory with modest capacity is more powerful than previously expected.     

Ambiguity in Our Technical Society

The spiritual situation at the turn of the millennium can be interpreted through Paul Tillich's appropriation of modernity, by analysis of the determinative structures and decisive trends of our age. The methods and organization of industry determine modern society. Spiritually, this situation results in the proliferation of means without ends, the objectification of natural structures, and the reduction of persons to things. Extrapolating from Tillich's analysis, the spiritual situation at the turn of the millennium can be understood as a quasi-religious struggle between the movements of liberal individualism and multiculturalism, both of which lose the sense of ambiguity. The communitarian movement and related interpretations remain the minority voice offering a mediating position.     

Inferences about which of J dependent groups has the largest robust measure of location

Recently, a multiple comparisons procedure was derived with the goal of determining whether it is reasonable to make a decision about which of J independent groups has the largest robust measure of location. This was done by testing hypotheses aimed at comparing the group with the largest estimate to the remaining J − 1 groups. It was demonstrated that for the goal of controlling the familywise error rate, meaning the probability of one or more Type I errors, well-known improvements on the Bonferroni method can perform poorly. A technique for dealing with this issue was suggested and found to perform well in simulations. However, when dealing with dependent groups, the method is unsatisfactory. This note suggests an alternative method that is designed for dependent groups.