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兴奋性氨基酸(EAAs) 广泛分布于中枢神经系统,参与多种生理过程包括学习、记忆和伤害感受等。然而,EAAs 受体的过度兴奋却可引发一系列细胞事件,最终导致神经元的损伤与死亡。许多神经退行性疾病如早老性痴呆、癫痫和肌侧索硬化症等都与EAAs 的兴奋毒作用有关。目前的研究表明,由EAAs 受体过度兴奋所引发的细胞内钙超载是导致神经元死亡的最终途径 相似文献
164.
Jake Epker Ann Matt Maddrey Randall Rosenblatt 《Journal of clinical psychology in medical settings》1999,6(4):393-403
The Multidimensional Pain Inventory (MPI) was utilized in a sample of adult outpatients with cystic fibrosis (CF) to assess their perception of pain and its psychosocial consequences. Subsequently, the data were compared to the ratings of pain and pain-related impairment in these patients as perceived by two nurses from the CF treatment team, as well as to a quantitative measure of illness severity. The results of these comparisons demonstrate that the majority of adult outpatients with CF reported experiencing lower levels of pain and pain-related impairment than expected, although the male patients tend to report experiencing significantly less impact in these domains than do the female patients. Additionally, the nurses do not underestimate the degree to which patients, especially males, experience pain and pain-related interference from chronic illness. Finally, there was no significant relationship between patients' self-report of pain severity or pain-related interference and an objective measure of disease severity. 相似文献
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166.
Susan Wolf 《The Journal of Ethics》1999,3(3):203-223
According to one influential conception of morality, being moral is a matter of acting from or in accordance with a moral point of view, a point of view which is arrived at by abstracting from a more natural, pre-ethical, personal point of view, and recognizing that each person's personal point of view has equal standing. The idea that, were it not for morality, rational persons would act from their respectively personal points of view is, however, simplistic and misleading. Because our nonmoral reasons cannot all be adequately captured as falling within any single, unified and coherent point of view, morality cannot be adequately understood as a matter of abstracting from such points of view and taking them all equally into account. After considering several ways of modifying the initial conception of morality in a way that accommodates the variety of nonmoral reasons that do not have their source in a personal point of view, the paper concludes with the suggestion that we free ourselves more thoroughly from the grip of the metaphor that takes morality as a whole to be a matter of acting in accordance with the judgments of a single unified and coherent point of view. 相似文献
167.
自控摄入小剂量酒精影响熟练驾驶行为的实验研究 总被引:1,自引:1,他引:0
一个小样本受试者内设计实验,受试者在实验允许的酒精剂量范围内自由选择摄入量。实验安排饮酒前,酒后30分钟、110分钟和170分钟四个测试阶段,分别检验受试者在模拟驾驶和实际驾驶两项任务中的认知行为。酒后30分钟实际驾驶的技能与其他三个测试期相比存在有意义的差别显著性;模拟测试任务中酒后对红、黄两种信号灯的认知反应时之间呈现显著性差别,酒后110分钟对黄色信号灯的反应明显延迟。研究提示:受试对酒精感受性的估计是不可靠的,小剂量酒精也能对驾驶行为构成伤害。 相似文献
168.
短时作业中警戒绩效影响因素的实验研究:兼用信号检测论分析 总被引:1,自引:0,他引:1
本文研究了短时(1小时内)作业中警戒绩效的一些影响因素。实验采用EP710警戒仪,研究了短时作业中时间、信号密度(信噪比)以及信号显著性(占空比)对警戒绩效的影响。使用的方法为信号检测论。因变量指标为辨别力指数d’和判断标准B。结果发现,作业时间和占空比对警戒绩效没有影响,信噪比对辨别力指数d’有影响但对判断标准B没有影响。结果提示,在短时作业中,信噪比对警戒绩效起显著作用. 相似文献
169.
Alan Williams 《Ethical Theory and Moral Practice》1999,2(1):47-55
In the popular folklore three-score-years-and-ten is treated as a fair innings for people, and thereby serves as an informal reference point for judgements about distributive justice within a community. But length of life alone is an insufficient basis for such judgements - a person's health-related quality-of-life also needs to be taken into account. If one of the objectives of public policy is to reduce inequalities in lifetime health, it will be demonstrated that this is very likely to require systematic discrimination against the older members of a community. The notion of community solidatity will also be tested, because a decision will need to be made as to whether the same fair innings applies to all members of the community, or whether some are entitled to more than others. The strength of the fair innings principle is that it brings these issues to the fore in a systematic way which should ais their resolition in a practical context. 相似文献
170.
The effect of superstitious thinking on psychosocial stress responses and perceived task performance 下载免费PDF全文
Previous research on superstitious belief, a subset of paranormal belief (Irwin, 1993 ), has suggested that people tend to invoke luck‐related superstitions in stressful situations as an attempt to gain an illusion of control over outcomes. Based on this, the current study examined whether luck‐related superstition, in the form of a “lucky” pen, could influence the psychological response to a psychosocial stressor. Participants (N = 114), aged between 17 and 59 years (M = 22.98, SD = 4.57) from James Cook University Singapore, were randomly assigned to one of four conditions: (a) no‐stress with no lucky pen; (b) no‐stress with a lucky pen; (c) stress with no lucky pen or; (d) stress with a lucky pen. The results revealed that participants provided with a lucky pen experienced lower state anxiety when exposed to the stressor. Further, participants provided with a lucky pen perceived their performance to be better than those without it. However, superstitious belief did not significantly change following exposure to stress. Taken together, the present findings add some support to the suggestion that belief in transferable luck may facilitate coping with a stressor. However, further research is needed to fully understand the mechanisms behind the potential benefits of superstitious belief. 相似文献