内隐和外显记忆任务之间的实验性分离:刺激的不同呈现形式的作用

通过操纵目标刺激的表面形式变化,在内隐和外显记忆任务之间,发现了实验性分离现象,图形识别任务受到了这种操纵的影响,再认任务则没有,同时发现,它们存在着依赖性的关系。对比相关研究,该实验结果表明,概念驱支任务对刺激的表面或知觉的物理性表现出敏感性,是在刺激的编码阶段;数据驱动任务在码阶段和提取阶段,均对其表现出敏感性,在刺激的提取阶段,这两种类型任务提取了刺激的某些共同成分。     

Current status of psychological research in organ transplantation

Research addressing the psychological concomitants of organ transplantation is reviewed. Specifically, cognitive, behavioral, and psychosocial correlates of kidney, heart, liver, and bone marrow transplantation in both children and adults are discussed. Despite several conceptual and methodological shortcomings of the psychologically-based research in this area, results seem to indicate that organ transplantation is associated with many psychological issues at pretransplantation, posttransplantation, and follow-up periods. Implications of these general findings for the advancing roles of the health psychologist in organ transplantation are discussed.     

Involvement of reactive oxygen species in emotional stress: A hypothesis based on the immobilization stress-induced oxidative damage and antioxidant defense changes in rat brain,and the effect of antioxidant treatment with reduced glutathione

We examined the oxidative damage and antioxidant defense changes with immobilization-induced emotional stress in the rat brain. Though superoxide dismutase activity remained unchanged, brain peroxidation was significantly accelerated by the immobilization stress. Membrane fluidity study with spin labeling in brain cortical membrane showed that immobilization stress induced an increase in microviscosity of membrane layer near the surface and in the ordering of membrane proteins but a decrease in microviscosity at the core of the membrane bilayer. The Na, K-ATPase activity decreased whereas the levels of some monoamines and their metabolites increased along with their metabolic rate. The administration of reduced glutathione showed a protective effect on the immobilization stress-induced stomach bleeding, oxidative damage and abnormal changes in the brain antioxidant defenses. Based on these results and on previous reports, we hypothesize that immobilization stress may induce the formation of reactive oxygen species which weakens the brain antioxidant defenses and induces oxidative damage. The antioxidant administration of reduced glutathione provides further evidence to support the above hypothesis, and also may provide clues in the search for a rational therapy to emotional stress. A possible correlation of emotional stress to aging is also discussed.     

三维虚拟空间中转头选中远离和靠近运动目标的操作特性差异

通过转头选中运动目标是虚拟现实(VR)中的常见操作,然而运动目标包含远离和靠近运动,确定两类操作的时间特性差异对设计高效的用户接口有重要的意义。本研究选取17名被试在VR中通过转头将球体光标快速准确地放入水平运动的球体目标内,并改变初始距离、目标容差和目标速度。总时间结果显示,远离运动的操作难度更大,初始距离和目标容差对远离和靠近运动的影响相似,目标速度对两类运动的影响相反。进一步将光标的移动过程划分为加速、减速和调整阶段,结果发现,远离运动的加速和减速时间大于靠近运动,但是两类运动的调整时间接近,并且只有目标容差对两类运动的影响一致。最后构建了总时间与三因素的函数模型,成功解释了两类运动的操作时间特性。本研究证明了远离与靠近运动具有不同的操作时间特性,为两类运动的独立交互设计提供了重要参考。     

道德概念垂直空间隐喻理解中的映射:双向性及不平衡性

通过4个实验考察道德概念垂直空间隐喻理解中的映射机制和特征。实验1采用空间Stroop范式,发现被试判断完道德词后,对判断随后呈现在屏幕上方或下方字母的反应时的差异不显著,没有发现词汇类型对空间位置的影响。实验2采用有意识迫选法,要求被试出声读出屏幕中央的道德词后,对屏幕上方或下方的希腊语非词进行二择一迫选,发现被试读出道德词后倾向于选择屏幕上方的非词,读出不道德词后倾向于选择屏幕下方的非词。实验3仍采用Stroop范式,发现被试做出空间"上"的判断后,对随后道德词的词义判断反应时显著快于不道德词,做出空间"下"的判断后,对不道德词的反应时显著快于道德词。实验4探讨空间位置是否会对判断人物的道德性产生影响,结果发现被试倾向于认为屏幕上方的人物是道德的,而屏幕下方的人物是不道德的。4个实验的结果表明,在道德概念垂直空间隐喻的理解中,映射的方式是灵活的、双向的,既可以由始源域向目标域映射,也可以由目标域向始源域映射,但两个方向上的映射力量是不平衡的。     

奖赏历史对自上而下注意控制的调节：促进还是干扰？

奖赏能够影响注意控制,但是关于奖赏历史对注意控制的影响还处于争论之中。本研究以大学生为被试,采用点探测范式,操作了奖赏历史和奖赏额度,考察了奖赏历史对自上而下注意控制的调节作用。实验一结果发现,有奖赏-无奖赏条件下前后阶段反应时无显著差异,无奖赏-有奖赏条件下有奖赏阶段的反应时显著短于无奖赏阶段。实验二操作了奖赏额度,结果与实验一一致。整个研究表明,奖赏历史促进自上而下注意控制,先前奖赏对随后自上而下注意控制产生持续促进效应。     

Neural localization of semantic context effects in electromagnetic and hemodynamic studies

Measures of electrical brain activity (event-related potentials, ERPs) have been useful in understanding language processing for several decades. Extant data suggest that the amplitude of the N400 component of the ERP is a general index of the ease or difficulty of retrieving stored conceptual knowledge associated with a word, which is dependent on both the stored representation itself, and the retrieval cues provided by the preceding context. Recordings from patients with brain damage, intracranial recordings, and magnetoencephalographic data implicate a (probably large portion of) the left temporal lobe as the largest source of the N400 semantic context effect, with a substantial but lesser contribution from the right temporal lobe. Event-related functional magnetic resonance (fMRI) studies using semantic context manipulations are dominated by observations of greater hemodynamic activity for incongruent sentence completions or semantically unrelated words than congruent or related words, consistent with the direction of the ERP effect. The locations of the hemodynamic effects show some variability across studies, but one commonly identified region is the left superior temporal gyrus, which is compatible with the electrophysiological results. A second commonly identified region in the fMRI studies is the left inferior frontal gyrus, which does not appear to make a substantial contribution to the N400 effect.     

Conflict of interest from a Romanian geneticist’s perspective

This paper examines Romanian bioethics regulations for biomedical sciences, looking in particular at the genetics area as a source for conflict of interest. The analysis is focused on the organizational level, national regulations, the sources for generating conflicts of interest, and management of conflicts. Modern biotechnology and gene technology are among the key technologies of the twenty-first century. The application of gene technology for medical and pharmaceutical purposes is widely accepted by society, but the same cannot be said of the development and application of gene technology in agriculture and food processing. Because the use of a technology in the production and processing of food is regarded more sceptically than in the production of biomedical products, there can be areas of conflict in many cases when communication is undertaken about gene technology in the agro-food sector. Ethical concerns play an important factor in this, but a society’s attitude to a developing technology is an amalgam of many effects which are beyond ethics as such. This paper contains a study carried out by the author for the Romanian Association for Consumer Protection about the attitudes of consumers towards genetically modified (GM) foods. This study revealed that in Romania more than 98% of consumers did not know anything about GM foods and frequently were confused about the definitions of these terms. In conclusion, it is necessary to say that there is a low level of knowledge regarding biotechnology in Romania and this is an important reason why there is neither public acceptance of gene technology products nor is there a rejection. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002. Ioana Ispas, MD in Molecular Biology, is a scientific researcher and Member of the Romanian Association for Consumer Protection, NCP for FP5-Quality of life and management of living resources.     

Cultural Diversity and Patients with Reduced Capacity: The Use of Ethics Consultation to Advocate for Mentally Handicapped Persons in Living Organ Donation

Theoretical Medicine and Bioethics - Living organ donation will soon become the source of the majority of organs donations for transplant. Should mentally handicapped people be allowed to donate,...     

死亡与重生：器官移植手术中社会工作服务的拓展

社会工作作为医疗团队中的一员,不仅认识到器官移植对病人及其家属、移植医学以及社会风气的积极意义与消极限制,而且注重围绕移植手术的不同阶段为病患及其家属开展心理及社会评估、个案与家庭辅导、资源整合以及社会支持等服务。