Multiple hydrogen trapping at monovacancies

Novel structures for multiple hydrogen atoms trapped at a monovacancy are discussed. Using atomistic simulations based on semiempirical interatomic potentials and density functional theory, we find low-energy configurations for four, five, and six hydrogen atoms around a monovacancy different than those that have been previously studied in the literature. The energetics of hydrogen binding are compared to results, both theoretical and experimental, previously published in the literature. We argue that up to four hydrogen atoms may be exothermically bound to monovacancy.     

What harm can it do?: A discussion of the potential for harm inherent in psychodynamic work

Abstract

This paper examines some of the ethical issues raised by the nature of psychodynamic work. It suggests that both the aims and the process of psychodynamic therapy raise ethical issues which we cannot responsibly ignore, but that if the work is to be effective it cannot be made wholly safe. That, however, does not absolve us from the requirement for taking care, and for thinking about what we are doing and what we are risking.     

Why We Must Leave Our Organs to Others

Organ procurement presents several ethical concerns (from what constitutes acceptable criteria for death to issues involved in specifically designating to whom an organ can be given), but none is more central than the concern for what are appropriate means for acquiring organs. The following discussion attempts a different perspective on the issue of organ procurement by arguing that, rather than appealing to our charitable consciences or our pocketbooks, relinquishing our organs after death in this day and age is, in fact, obligatory for most people. Each of us is pressed by the growing demand for our organs should we die “rightly,” and that desperate need has risen to such a level that not to release our organs for transplantation would constitute a serious moral wrong.     

Frontal and parietal lobe involvement in the processing of pretence and intention

We assessed whether different processes might be at play during pretence understanding by examining breakdowns of performance in participants with acquired brain damage. In Experiment 1 patients with frontal or parietal lesions and neurologically intact adults were asked to categorize videos of pretend and real actions. In Experiment 2 participants saw three types of videos: real intentional actions, real accidental actions, and pretend actions. In one session they judged whether the actions they saw were intentional or accidental, and in a second session they judged whether the actions were real or pretend. Parietal patients had particular difficulties in the identification of pretend actions, and both parietal and frontal patients were more impaired than controls in understanding the intentional nature of pretence. Analyses of individual patients’ performance revealed that parietal lesions, and in particular lesions to the temporo-parietal junction, impaired the ability to discriminate pretend from real actions. However, this did not necessarily affect the discrimination of intentional from unintentional actions, which instead may be independently disrupted by damage to frontal areas. Moreover, spared ability to discriminate pretend actions from real actions, and intentional actions from accidental actions, did not grant a full conceptual understanding of the intentional nature of pretence. The implications for pretence understanding are discussed.     

Cloninger's Temperament and Character Inventory Correlates with Personality Characteristics of Organ Donation Advocates

Temperament and Character Inventory (TCI) and background questionnaire data were collected from a sample of men and women organ donation advocates (N = 362) as part of a national study to investigate their personality characteristics, temperaments, and attitudes about organ donation advocacy. Goals included identifying unique traits for advocates, and response consistency between the TCI and questionnaire. The TCI results included high scores on Cooperativeness and Self-Directedness, and low on Harm Avoidance dimensions. The questionnaire results indicated that most advocates were White, married, college-educated females, who typically spent less than 2 hr with potential donor families, were satisfied with life and job, and believed they would be in a donation position 2 years from the time surveyed. TCI and questionnaire measures were correlated for Self-Transcendence and Spirituality, Helpfulness and Job Satisfaction, and Compassion and Identification variables.     

Effects of chronic administration with high doses of testosterone propionate on behavioral and physiological parameters in mice with differing basal aggressiveness

The effects of testosterone propionate, an anabolic‐androgenic steroid, on the behavior displayed during a social encounter by gonadally intact male mice were investigated. Animals were distributed into three groups according to their attack latency in a pre‐screening test (high‐, moderate‐, and low‐ attacking mice) and each group received weekly injections of 60 or 120 mg/kg of testosterone or sesame oil for 10 weeks. Behavioral tests were then carried out. Afterwards, organs were weighed and blood samples collected in order to obtain hormonal data. Treatment had a differential impact on attack in the three groups of animals. Only the high‐attacking testosterone‐treated mice showed lower total duration of attack than their controls. Those that received 60 mg/kg spent more time exhibiting exploratory behaviors. As an index of the anabolic activity of the drug, all testosterone‐treated mice had heavier kidneys and, as an index of the androgenic activity of testosterone propionate, they had heavier seminal vesicles, lighter testes, and showed higher testosterone levels in a dose‐dependent way than their controls. Hence, the effect of treatment on peripheral physiological parameters was similar in all three groups whereas behavioral effects differed depending on basal aggressiveness, considered a characteristic of coping style. Aggr. Behav. 29:173–189, 2003. © 2003 Wiley‐Liss, Inc.     

上级反馈对员工行为的影响

采用2×2(反馈方式、反馈对象)两因素组间实验设计,选取303名被试考察了上级反馈对员工积极整合行为倾向、冲突行为倾向和中立行为倾向的影响,以及个人主义-集体主义倾向对这种影响的调节作用。结果表明,Singelis、Triandis等人有关个人主义、集体主义的理论框架基本适合中国被试,个体的个人主义、集体主义倾向对反馈的效果起到一定的调节作用。领导的反馈方式、反馈针对的对象对员工的行为主效应都显著,上级的表扬会增加员工的中立行为倾向,针对个人的反馈会引起较强的冲突行为倾向。     

Voluntary aspects of attentional control setting for detecting a feature‐defined target1

Abstract: Singleton targets that differ from distractors in a single salient attribute can be discerned regardless of the number of items in the display. Recent studies have indicated that the perception of singleton targets is facilitated by an attentional control setting. We focused on the voluntary aspect of the attentional control setting. Psychophysical and functional magnetic resonance imaging (fMRI) experiments examined the temporal characteristics of the attentional control setting by using an auditory cue. In both experiments, an auditorily cued feature‐search task was used. The cue validity (valid vs. neutral) and the cue lead time (CLT) were varied. In the psychophysical experiment, we established the effect of a symbolic cue on detection of a singleton. When the CLT was short or the cue was neutral, there was no facilitation, as re?ected by the slow activation of the attentional control setting. In our fMRI experiment, the brain activity indicates that this detection task activated the prefrontal cortex. These results demonstrate that the attentional control setting for facilitation of the singleton‐target perception modulates activity in regions of the prefrontal cortex.     

Brain Oxidative Damage Following Acute Immobilization and Mild Emotional Stress

We studied the role of free radicals on brain oxidative damage in rats after acute immobilization stress (restraint) and mild emotional stress (handling). To investigate brain oxidative damage, CuZn and Mn dependent superoxide dismutase (CuZn SOD, Mn SOD) activities, lipid peroxidation (TBARs), Na ⁺ K ⁺ ATPase activity, protein carbonyl (PrC), and reduced and oxidized glutathione (GSH, GSSG) levels were measured in the cerebral cortex (CTX), hippocampus (HIP), and striatum (ST) of the animals after the two different stress stimuli. Because stress produces abnormalities in the hypothalamic-pituitary-adrenal axis, the intensity of the two stress conditions were measured by plasmatic corticosteroid (COR) levels: particularly, COR levels doubled in handled rats and increased 15-fold in restrained animals. The SOD activities increased in CTX and decreased in HIP of the handled rats, while in ST a significant decrease in handled animals but an increase in restrained animals occurred. TBARs, GSH, and GSSG levels remained unchanged, while an index of glutathione redox decreased significantly in ST of handled animals and in CTX of restrained ones. Na ⁺ K ⁺ ATPase activity increased significantly in the HIP and ST of both groups of stressed rats. The stress induced a remarkable increase in PrC levels in all studied cerebral areas. These findings provide evidence to support the idea that stress produces oxidants but that the oxidative damage in stress differs in cerebral areas and could contribute to the degenerative mechanism of aging.     

Tool use in left brain damage and Alzheimer's disease: What about function and manipulation knowledge?

Tool use disorders are usually associated with difficulties in retrieving function and manipulation knowledge. Here, we investigate tool use (Real Tool Use, RTU), function (Functional Association, FA) and manipulation knowledge (Gesture Recognition, GR) in 17 left‐brain‐damaged (LBD) patients and 14 AD patients (Alzheimer disease). LBD group exhibited predicted deficit on RTU but not on FA and GR while AD patients showed deficits on GR and FA with preserved tool use skills. These findings question the role played by function and manipulation knowledge in actual tool use.