治疗糖尿病创新药物研究

本论文从治疗2型糖尿病药物应用现状出发,通过对2型糖尿病病理的认识,新发现的主要受体和相关药靶等方面进行分析。指出随着对糖尿病认识的深入发展,治疗糖尿病创新药物研究的发展趋势也发生了相应的变化,就是从局部治疗到全身综合考虑,从药物外部直接地干预到增强自身调节功能。为治疗2-型糖尿病药物发展指明了方向。     

Recognizing Terrorism

It has been claimed that most of the world’s preventable suffering and death are caused not by terrorism but by poverty. That claim, if true, could be hard to substantiate. For most terrorism is not publicly recognized as such, and it is far commoner than paradigms of the usual suspects suggest. Everyday lives under oppressive regimes, in racist environments, and of women, children, and elders everywhere who suffer violence in their homes offer instances of terrorisms that seldom capture public attention. Or so this essay argues, through exploring two models of terrorism and the points of view highlighted by each.     

Effective CCTV and the challenge of constructing legitimate suspicion using remote visual images

This paper compares the effectiveness of public CCTV systems according to meta‐reviews, with what might be expected based upon theoretical predictions. The apparent gulf between practice and prediction is explored in the light of the challenges faced by CCTV operators in terms of effective target selection. In addition, counter‐intuitive reactions by members of the public to situational symbols of crime deterrence may also undermine the efficacy of CCTV. Evidence is introduced and reviewed that suggests CCTV operators may employ implicit profiles to select targets. Essentially, young, scruffy males who appear to be loitering are disproportionately targeted compared with their base rate use of surveyed areas. However, the extent to which such a profile is diagnostic of criminal intent or behaviour is unclear. Such profiles may represent little more than ‘pattern matching’ within an impoverished visual medium. Finally, suggestions for future research and effective CCTV operator practice are offered in order to improve target selection. Copyright © 2008 John Wiley & Sons, Ltd.     

文字与图片呈现形成想象空间记忆的比较

学习通过文字或图片方式显示的空间布局材料之后,采用空间定位任务．分别检验在不同朝向和相对位置的条件下,对想象空间方位判断的差异。结果表明,使用图片进行空间布局的学习,记忆后再各自以同样显示形式进行空间定位任务时,判断的速度比使用文字的反应时要快;同时,无论是文字还是图片形式呈现．在进行想象转向时．都会呈现朝向效应和相对位置效应。     

FOK判断与可接近信息之间的关系

通过三个实验,用语义联想集大小不同的中文单字词研究了靶项目联想集的大小与FOK判断等级和准确性的关系。实验一通过两种不同联想集大小的靶子,比较外显的、提取出的信息和内隐的、语义网络中固有的被激活信息量对FOK判断等级和FOK判断准确性是否有不同的影响。实验二和实验三通过不同的靶子呈现时间和学习遍数,比较不同的识记强度对不同大小联想集的靶子的FOK判断等级和FOK判断准确性的影响。实验结果表明：FOK判断等级随外显的、提取出的信息总量的增多而增高,随内隐的、语义网络中固有的被激活信息量的增多而降低。FOK判断准确性随靶子本身的激活强度的增强而增高,随内隐的、语义网络中固有的被激活信息的激活强度的增强而降低,FOK判断准确性取决于这两种激活强度的综合作用。     

视空工作记忆负载对真实场景搜索绩效的影响

采用视空工作记忆任务和真实场景搜索任务相结合的双任务范式, 结合眼动技术将搜索过程划分为起始阶段、扫描阶段和确认阶段, 探究视空工作记忆负载对真实场景搜索绩效的影响机制, 同时考查试次间搜索目标是否变化、目标模板的具体化程度以及搜索场景画面的视觉混乱度所起的调节作用。结果表明, 视空工作记忆负载会降低真实场景搜索的成绩, 在搜索过程中表现为视空负载条件下扫描阶段持续时间的延长、注视点数目的增加和空间负载条件下确认阶段持续时间的延长, 视空负载对搜索过程的影响与目标模板的具体化程度有关; 空间负载会降低真实场景搜索的效率, 且与搜索画面的视觉混乱度有关, 而客体负载则不会。由此可见, 视空工作记忆负载对真实场景搜索绩效的影响不同, 空间负载对搜索过程的影响比客体负载更长久, 二者均受到目标模板具体化程度的调节; 仅空间负载会降低真实场景的搜索效率, 且受到搜索场景画面视觉混乱度的调节。     

场景情境和目标模板在视觉搜索中的交互作用

以真实场景图像中的物体搜索为实验任务, 操纵场景情境和目标模板, 采用眼动技术将搜索过程分为起始阶段、扫描阶段和确认阶段, 考察场景情境和目标模板对视觉搜索过程的影响机制。结果发现, 场景情境和目标模板的作用方式及时间点不同, 二者交互影响搜索的正确率和反应时, 仅场景情境影响起始阶段的时间, 随后二者交互影响扫描阶段和确认阶段的时间及主要眼动指标。作者由此提出了场景情境和目标模板在视觉搜索中的交互作用模型。     

选择集大小对网购决策态度和行为的影响

研究探讨网络购物中选择集大小对决策态度和行为的影响,以及目标确定性和产品类型对该关系的调节作用。采用2(大选择集vs.小选择集)×2(目标明确vs.目标不明确)×2(体验型产品vs.搜索型产品)的组间设计,发现大选择集组选择满意度、自信心更高,但延迟选择更多,出现态度-行为分离。目标不明确时,大选择集组延迟选择更多。     

Sensitivity to local sentence context information in lexical ambiguity resolution: evidence from left- and right-hemisphere-damaged individuals

Using a cross-modal semantic priming paradigm, the present study investigated the ability of left-hemisphere-damaged (LHD) nonfluent aphasic, right-hemisphere-damaged (RHD) and non-brain-damaged (NBD) control subjects to use local sentence context information to resolve lexically ambiguous words. Critical sentences were manipulated such that they were either unbiased, or biased toward one of two meanings of sentence-final equibiased ambiguous words. Sentence primes were presented auditorily, followed after a short (0 ms) or long (750 ms) interstimulus interval (ISI) by the presentation of a first- or second-meaning related visual target, on which subjects made a lexical decision. At the short ISI, neither patient group appeared to be influenced by context, in sharp contrast to the performance of the NBD control subjects. LHD nonfluent aphasic subjects activated both meanings of ambiguous words regardless of context, whereas RHD subjects activated only the first meaning in unbiased and second-meaning biased contexts. At the long ISI, LHD nonfluent aphasic subjects failed to show evidence of activation of either meaning, while RHD individuals activated first meanings in unbiased contexts and contextually appropriate meanings in second-meaning biased contexts. These findings suggest that both left (LH) and right hemisphere (RH) damage lead to deficits in using local contextual information to complete the process of ambiguity resolution. LH damage seems to spare initial access to word meanings, but initially impairs the ability to use context and results in a faster than normal decay of lexical activation. RH damage appears to initially disrupt access to context, resulting in an over-reliance on frequency in the activation of ambiguous word meanings.