靶控输注技术的个体化应用

靶控输注技术作为一种新兴的静脉给药方法,凭借其独特的优势已广泛的应用于临床麻醉,但个体差异的存在使靶控输注技术的应用受到局限。通过对病人个体差异的哲学分析,阐述个体差异对靶控输注技术的影响。并就克服个体差异的影响,提出了靶控输注技术的个体化应用。     

重复线索化和靶子注意定向对返回抑制的影响

在返回抑制范式下 ,利用线索—靶子模式进行了两个实验 ,以大学生为被试 ,以重复线索化次数来操纵线索化阶段的注意 ,以靶子的注意定向来操纵靶子加工阶段的注意 ,探讨注意对返回抑制的影响。实验一采用连续线索化方式 ,发现当靶子为自主性注意定向时 ,线索化次数对返回抑制有显著影响 ,线索化 3次时返回抑制值大于线索化 1次和 2次 ;当靶子为反射性注意定向时 ,线索化次数对返回抑制无影响。实验二采用交叉线索化方式 ,发现线索化次数对返回抑制的影响正好与实验一相反。两个实验一致表明 ,无论是线索化阶段的注意 ,还是靶子加工阶段的注意 ,均对返回抑制有显著影响 ;并且 ,在对返回抑制的影响上 ,二者存在显著交互作用。从而支持注意影响返回抑制的观点。该结果对返回抑制的机制研究有一定意义。     

Attentional capture by items that match episodic long-term memory representations

A remarkable ability of the human visual system is the implementation of attentional control settings (ACSs) that govern what stimuli capture or hold attention. We provide evidence that ACSs can be specified by episodic long-term memory representations. In all experiments, participants memorized 30 images of objects that they then monitored for in an attention task, inducing an episodic-based ACS. In Experiments 1a and 1b, only studied cues in a cueing task captured attention. We confirmed these cueing effects reflect capture by testing for inhibition of return in Experiment 2a, and controlled for perceptual masking by cues in Experiment 2b. In Experiment 3 we determined that ACSs are specifically supported by episodic retrieval, by dividing studied images into two sets and designating one as the targets in a rapid serial visual presentation task: Only target-set matching distractors produced a spatial blink (captured attention). These results extend our understanding of the representations specifying ACSs.     

从信任违背到信任修复:道德情绪的作用机制

早期学者已经从认知的角度分析信任违背的原因及修复方式。近年来,情绪对信任修复的影响引起了重点关注,但是情绪在其中的作用机制并未得到解答。当前的研究主要从情绪影响信任的线索依赖效应和离散情绪(内疚、羞愧、愤怒、悲伤等)对信任修复的影响这两个角度着手研究情绪对信任修复的影响。通过文献梳理发现内疚和共情两种道德情绪是影响信任修复最重要的情绪因素:内疚能够促进受信方做出补偿行为,共情能够促进信任方宽恕他人。基于此构建了道德情绪的信任修复模型,并考虑了目标线索和信任方的特质性宽恕的调节作用。同时建议未来的研究进一步探讨其他离散情绪尤其是道德情绪对信任修复的作用,并关注情境与情绪的交互作用。     

Searching for two categories of target in dynamic visual displays impairs monitoring ability

Target onsets in dynamically changing displays can be predicted when contingencies exist between different stimulus states over time. In the present study, we examined predictive monitoring when participants searched dynamically changing displays of numbers and colored squares for a color target, a number target, or both. Stimuli were presented in both contiguous and discrete spatial configurations. Response time (RT) and accuracy were recorded, and evidence of predictive monitoring was assessed via first fixations and refixations of target‐predictive stimuli. RTs to target onsets and evidence of predictive monitoring were reduced in dual‐target, relative to single‐target, conditions. Further, predictive monitoring did not speed RTs but was influenced by display configuration. In particular, discrete displays impaired monitoring for number targets in the dual‐target condition. Implications exist for real‐world visual tasks involving multiple target categories and for visual display design.     

Predictive Pointing Movements and Saccades Toward a Moving Target

The authors investigated whether and, if so, how velocity information is used to control predictive manual pointing movements and saccades. Participants (N = 6) intercepted an occluded moving target as if it were still visible. They kept their eyes fixated while the target moved. The target traveled over a fixed distance and changed its velocity on the way. The presentation time of the final velocity was varied. Both the eye and the hand overshot the slow target and undershot the fast target, particularly when the duration of the final velocity was short. Thus, responses were biased in the direction of the target's initial velocity. The error seemed to arise because participants did not take their latency into account when aiming at the target. Instead, they strategically aimed farther ahead when the target was fast. Amplitude was also more related to the position of velocity change than to final velocity duration. Both findings suggest that target velocity is not extrapolated but that individuals add an increment to the position of velocity change.     

阅读中的眼跳目标选择问题

读者在阅读中面临如何选择眼跳落点位置的问题。研究者在有词间空格的字母文字中(如英语和德语)发现人们倾向于将眼跳落在词中心偏左的位置,这个位置被称为偏好注视位置(preferred viewing location,PVL)。中文文本并没有空格来标记词边界信息,这使得中文阅读的眼跳目标选择机制更加复杂。近年来,研究者从中央凹—副中央凹动态调节的角度研究了阅读中眼跳目标选择的机制。结果发现在中文阅读中眼跳目标选择受到中央凹和副中央凹信息加工的共同影响,而副中央凹的加工直接决定了眼跳落点位置。     

Cerebellar neurophysiology in Gilles de la Tourette syndrome and its role as a target for therapeutic intervention

Therapy resistance of approximately one‐third of patients with Gilles de la Tourette syndrome (GTS) requires consideration of alternative therapeutic interventions. The article demonstrates the role of the cerebellum in neuropsychiatric disorders and GTS in particular, specifically its role in functions relating to motor and cognitive symptoms. Certain circuits in the cerebellum have been shown to undergo learning‐induced changes during conditioning, with cells in the cortex of the cerebellum appearing to decrease their activity whilst those in deep nuclei seem to do the inverse. Evidence exists showing that abnormal excitability of the motor cortex via the cerebellum could be expected to participate in motor tics in GTS possibly due to aberrations in certain structures of involved circuits. The role of the cerebellum in learning and plasticity processes renders it a strategic and valuable structure to consider for brain stimulation when investigating potential treatment options for neuropsychiatric disorders such as GTS. This article puts forth the concept of using non‐invasive and invasive brain stimulation techniques as a novel platform for non‐pharmacological neuromodulation of GTS symptoms.     

不同目标标记方式对多目标追踪表现的影响

有关多目标追踪的研究多采用目标闪烁数次或目标周围出现方框等视觉方式对目标进行标记。在已有研究基础上,通过2个实验比较了不同目标数量下视觉平行标记、视觉序列标记、听觉序列标记(视听跨通道标记)和视听双通道序列标记4种目标标记方式对多目标追踪表现的影响。研究结果表明在多目标追踪任务中,线索阶段目标的视觉标记比视听跨通道标记更有效,且不受目标的序列标记或平行标记的影响,而视觉和听觉编码结合（视听双通道标记）可以促进任务难度较高时的追踪表现。