The utilization of genetic counselors within a newborn screening program

Genetic counselors have participated in the Michigan Newborn Screening Program on a contractual basis since 1988. Their role includes newborn screening education and training, newborn nursery site visits, and monitoring newborn screening in hospitals. Their impact has been to improve the quality of newborn screening services by reducing errors and increasing completion of data fields on newborn screening cards, improving hospital nursery cooperation and problem solving, and enhancing health department response to specific problems.     

Minimizing the number of observations: A generalization of the spearman-brown formula

A new method for determining the minimum number of observations per subject needed to achieve a specific generalizability coefficient is presented. This method, which consists of a branch-and-bound algorithm, allows for the employment of constraints specified by the investigator.     

Influential observations in principal factor analysis

We propose a method for detecting influential observations in iterative principal factor analysis. For this purpose we derive the influence functionsI(x; LL ^T ) andI(x; ) for the common variance matrixT =LL ^T and the unique variance matrix , respectively, in the common factor decomposition =LL ^T + . A numerical example is given for illustration.The authors are grateful to Tomoyuki Tarumi and Atsuhiro Hayashi for their kind permission to use their software Seto/B for drawing Figures 1 and 2 and to anonymous reviewers for comments on the paper.     

The Drinking Expectancy Questionnaire: A revised measure of alcohol-related beliefs

Alcohol-related expectancies have been recently proposed as potentially important determinants of drinking behavior. This study describes the development of a New Zealand measure of such beliefs, the Drinking Expectancy Questionnaire (DEQ). Items selected through interviews, literature review, and the modification of other relevant questionnaires were piloted on 333 drinkers in a community sample and 275 college students. Factor analyses of both samples revealed nine alcohol reinforcement domains relating to assertiveness, affective change, sexual enhancement, social enhancement, relaxation, cognitive impairment, dependence, carelessness, and aggression. The potential clinical and research possibilities using this revised expectancy measure are briefly discussed, along with the scale's strength and weaknesses.The financial assistance of the Alcoholic Liquor Advisory Council of New Zealand in conducting this study is gratefully acknowledged.     

HUMANITY IN THE WORLD OF LIFE

Abstract. The position and role of humanity in the world of life is examined in the light of the ontological structure of life itself. This problem is approached by considering the possible units of life representing various modes of life phenomena. I argue that the only meaningful unit of life without interposing some special external conditions is "global life" framed in a star-planet system. Any other possible unit of life exhibited by various kinds of individuals is conditional in the sense that it would leave out an essential part as "co-life." The relationship between human being and the global life should be understood in this general scheme of individual and global life. It is emphasized, however, that human being occupies a unique position in global life in the sense that humanity can promote either a cancerous situation or a healthy higher-order enhancement of the global life.     

DISCIPLINING RELATIVISM AND TRUTH

Abstract. Imre Lakatos's philosophy of science can provide helpful leads for theological methodology, but only when mediated by the disciplines that lie between the natural sciences and theology. The questions of relativism and truth are used as indices for comparing disciplines, and Lakatos's theory of natural science is taken as the starting point. Major modifications of Lakatos's work are demanded as one moves from the natural sciences, through economics, the interpretive social sciences, literary theory, and into theology. Although theology may consist of Lakatosian research programs, it also includes programs of interpretation and programs for living. This conclusion must influence our definition of theological truth and our assessment of theological relativism.     

Children's choice: Sensitivity to changes in reinforcer density

Two experiments were carried out in which children's sensitivity to changes in reinforcer density (number of reinforcers per session) was measured in a choice paradigm. In Experiment 1, 24 girls (ages 6, 9, and 12 years) performed on concurrent-chain schedules of reinforcement. The initial links were variable-interval 10-s schedules. One terminal link always gave three tokens after 30 s, but the parameters associated with the other were varied. Independent manipulations of reinforcer size (two tokens or four tokens) and prereinforcement delay (25 s or 65 s) led to equal changes in the relative density of tokens that could be earned on the schedules. Subjects at all ages were sensitive to changes in reinforcer density brought about by changes in reinforcer size, whereas only 3 12-year-olds showed sensitivity to the changes brought about by manipulation of prereinforcer delay. In Experiment 2, titration procedures were used to test the extent of this insensitivity to delay in 32 6- and 12-year-old children. In these procedures, a repeated choice of the large reinforcer increased the delay to its delivery, and a repeated choice of the small reinforcer reduced the delay to the delivery of the large reinforcer. Whereas 6-year-old boys and girls tended to maintain a strong preference for the large reinforcer, so increasing the delay to its delivery, 12-year-olds tended to distribute their responses to both alternatives, thus producing a stable level of delay to the large reinforcer. The results from the two experiments support the idea of two stages in the development of adaptive intertemporal choice.     

A quantitative analysis of chain-schedule performance

Six pigeons were trained with a chain variable-interval variable-interval schedule on the left key and with reinforcers available on the right key on a single variable-interval schedule arranged concurrently with both links of the chain. All three schedules were separately and systematically varied over a wide range of mean intervals. During these manipulations, the obtained reinforcer rates on constant arranged schedules also frequently changed systematically. Increasing reinforcer rates in Link 2 of the chain increased response rates in both links and decreased response rates in the variable-interval schedule concurrently available with Link 2. Increasing Link-1 reinforcer rates increased Link-1 response rates and decreased Link-2 response rates. Increasing reinforcer rates on the right-key schedule decreased response rates in Link 1 of the chain but did not affect the rate in Link 2. The results extend and amplify previous analyses of chain-schedule performance and help define the effects that a quantitative model must describe. However, the complexity of the results, and the fact that constant arranged reinforcer schedules did not necessarily lead to constant obtained reinforcer rates, precluded a quantitative analysis.     

Algorithmic shaping and misbehavior in the acquisition of token deposit by rats

In two experiments, rats were trained to deposit ball bearings down a hole in the floor, using an algorithmic version of shaping. The experimenter coded responses expected to be precursors of the target response, ball bearing deposit; a computer program reinforced these responses, or not, according to an algorithm that mimicked the processes thought to occur in conventional shaping. In the first experiment, 8 of 10 rats were successfully shaped; in the second, 5 of 5 were successfully shaped, and the median number of sessions required was the same as for a control group trained using conventional shaping. In both experiments, “misbehavior,” that is, excessive handling and chewing of the ball bearings, was observed, and when the algorithmic shaping procedure was used, misbehavior could be shown to occur in spite of reduced reinforcement for the responses involved.     

Visually guided catching and tracking skills in pigeons: A preliminary analysis

Research on reaching, tracking, and catching in the pigeon has been hampered by limitations of technology. A new system was developed in which the target was a small rectangle presented on a video display terminal and the pecking response was detected with touch technology. The target moved up and down vertically with sinusoidal velocity. A coincidence between the location of the pigeon's beak and the cursor produced reinforcement. The pigeon pecked ahead and behind the target, but most pecks occurred behind the target so the dominant tracking strategy was lagging. The pigeon was adept at “catching” the target at many locations throughout the trajectory. Transfer of motor learning was tested on probe trials during which the trajectory changed from vertical to horizontal. On transfer trials the pigeons' dominant pattern of pecking immediately shifted from vertical to horizontal. The motor skill displayed by the pigeons was flexible and adaptive, suggesting that the pigeons had learned to track the cursor.