应用分子靶向治疗的时机选择

分子靶向药物的出现显示出肿瘤治疗传统模式的重要进展。与传统放疗、化疗相比,分子靶向治疗因其特异性高、不良反应轻微,在恶性肿瘤个体化治疗中扮演重要角色。十五年来,分子靶向药物的出现,给肿瘤的治疗模式带来重大改变,也给临床医生带来新的挑战。准确把握分子靶向药物应用时机,获得最大临床效果,已成为肿瘤治疗领域关注热点。本文就非小细胞肺癌、消化系统肿瘤、乳腺癌、肾癌治疗中分子靶向药物如何选择应用时机进行阐述。     

医学影像学见习应用PACS教学法与传统读片教学法的对比研究

将中南大学湘雅医学院2010级临床医学五年制197名学生随机分成两组,在医学影像学见习教学过程中分别应用影像存储及传输系统（PACS）教学法（98人）及传统读片教学法（99人）,学期结束时对两组学生考试成绩进行分析,并对PACS组学生进行问卷调查及结果分析.统计数据显示,PACS组学生读片测验及卷面考试中,病例分析题成绩显著高于传统读片组,问卷调查显示PACS组学生大多数认可该教学方法.因此,应用PACS教学有助于提高学生的临床分析能力及主动学习的能力,是学生欢迎的教学方式.但对医学影像学基本知识的传授,应用PACS法较传统读片法并无明显优势.     

人工肝支持系统治疗肝衰竭的研究进展

目前肝衰竭发病率和病死率仍然较高,肝衰竭成为威胁患者生命的严重疾病。基于肝脏具有强大再生能力,人工肝支持系统作为一种“过渡”措施,为肝衰竭患者的肝功能恢复赢得时间。人工肝支持系统根据性质不同分为非生物型人工肝、生物型人工肝和混合型人工肝。目前非生物型人工肝已在肝病治疗领域被广泛应用,但生物型及混合型人工肝的临床应用还存在很多问题需要进一步研究和解决。因此本文对人工肝的作用、临床应用现状、存在问题及研究进展进行综述。     

语言理解中情绪的动态模拟

采用混合实验设计, 句子-图片匹配范式和动态过程再现范式, 以包含静态情绪和动态变化情绪信息的句子为实验材料, 以被试对图片的反应时间为因变量指标, 通过不同时间间隔的设置以及不同的实验程序, 探讨了语言理解中静态情绪和动态情绪的心理模拟及其时间进程。结果表明：(1)被试对情绪的心理模拟与句中的语言描述一致, 情绪语境能够激活被试的经验模拟。(2)被试在句子理解加工的初期就能迅速、即时地模拟静态情绪信息, 且这种模拟具有一定的稳定性和持久性。(3)被试可以对动态变化的情绪进行动态的心理模拟, 不过这种模拟所需的时间要长, 是在句子理解加工的后期完成的。被试对不同情绪变化方向的句子模拟受到原情绪状态的影响, 当阅读由消极情绪向积极情绪变化的句子时, 由于被试固着于原来的消极情绪而发生了模拟积极情绪的困难。     

基于系统动力学的群体情绪传播模型

选取某高校20个教学班级共计614人为被试,采用心理学实证与系统动力学（system of dynamic）与社会网络（social network）建模相结合的研究方法,对群体情绪传播的动力学规律进行了建模,并将模型仿真结果与心理实验结果进行了比对。结果表明,所建立的模型能够较好地刻画出群体情绪传播的动力学规律,具有较高的生态效度。该模型的建立对群体性事件的定量预警与监控提供了基础理论依据。     

Neuroticism,BIS, and reactivity to discrete negative mood inductions

Research has established relationships between the personality dimensions of neuroticism and BIS and broad negative emotional reactivity. However, few researchers have examined the relationships among neuroticism, BIS, and discrete negative emotional reactivities. The present study examined whether individuals scoring high on neuroticism and BIS were more reactive across four discrete negative mood inductions, relative to those scoring low on these traits. Participants (n = 166) completed personality questionnaires, measures of current mood, viewed a specific mood-inducing film clip (sadness, anger, fear or disgust) and then reported their moods a second time. Results revealed that neuroticism/BIS was associated with high reactivity to the fear and sadness inductions. Neuroticism/BIS did not predict anger or disgust reactivity, but neuroticism/BIS and extraversion/BAS interacted in predicting anger. Although further research is needed to extend generalizability, it appears that neuroticism and BIS predict negative emotional reactivity broadly, but not ubiquitously.     

Accountability,Collaboration, and Social Change: Ethical Tensions in an Action Research Project to Address Untested Sexual Assault Kits (SAKs)

We conducted a collaborative action research project with stakeholders in Detroit, Michigan, to develop long‐term policy strategies to resolve ~11,000 untested rape kits that were discovered in a police storage facility in August 2009. In our research, we uncovered overwhelming evidence of victim‐blaming behaviors and fundamental disrespect of rape survivors by the police, which directly contributed to their decisions not to submit kits for forensic testing. We had an ethical responsibility to report these negative findings accurately and completely, and in doing so, we were concerned that police stakeholders might disengage from the action research project and hamper our other ethical responsibilities to promote general and public welfare. In this article, we examine the ethical challenges of balancing accountability, collaboration, and social change.     

Using Community Partnerships to Better Understand the Barriers to Using an Evidence‐Based,Parent‐Mediated Intervention for Autism Spectrum Disorder in a Medicaid System

Service use disparities have been noted to impede under‐resourced families' ability to access high‐quality services for their child with autism spectrum disorder (ASD). These disparities are particularly relevant for parent‐mediated interventions and may suggest a lack of fit between these interventions and the needs of under‐resourced community settings. This study used Roger's Diffusion of Innovations theory to guide community partnerships aimed at understanding the perceived compatibility, complexity, and relative advantage of using an evidence‐based, parent‐mediated intervention (Project ImPACT) within a Medicaid system. Three focus groups were conducted with 16 Medicaid‐eligible parents, and three focus groups were conducted with 16 ASD providers operating within a Medicaid system. Across all groups, parents and providers reported general interest in using Project ImPACT. However, primary themes emerged regarding the need to (a) reduce the complexity of written materials; (b) allow for a more flexible program delivery; (c) ensure a strong parent–therapist alliance; (d) involve the extended family; and (e) help families practice the intervention within their preexisting routines. Results are discussed as they relate to the design and fit of evidence‐based, parent‐mediated interventions for under‐resourced community settings.