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One measure of the impact of genetic counseling and testing (GCT) is the extent to which it fosters behavioral change that is consistent with mutation status. We describe and illustrate how two different signal detection methods, receiver operating characteristic (ROC) analysis and recursive partitioning, can be used in this context to evaluate the impact of GCT. We analyzed real screening behavior data obtained in the 12 months following GCT for Hereditary Nonpolyposis Colon Cancer (HNPCC) using these two different signal detection approaches. Each approach demonstrated that GCT had an impact on behavioral outcomes, and was effective in fostering behavioral outcomes appropriate to mutation status. The ROC approach demonstrated that GCT was effective because mutation positive and mutation negative individuals could be distinguished on the basis of the number of recommended screening behaviors. The recursive partitioning approach demonstrated that GCT was effective because there were generally high rates of adherence to screening guidelines among subjects. The recursive partitioning technique also identified four subgroups of subjects, each with distinct characteristics, for which tailored interventions could be developed to increase rates of adherence to screening guidelines. Signal detection methods are easily implemented and are useful techniques for evaluating the impact of GCT. 相似文献
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工作应激与个体归因特点关系的研究 总被引:1,自引:0,他引:1
工作应激一直是组织行为中的热点问题,但综观前人研究,很少有研究者从归因的视角揭示其产生过程。本研究从个体的应激源感受性出发,探讨了个体归因特点与其工作应激的关系,建构了相应的模型,并结合压力管理问题,对研究进行了有益展望。 相似文献
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素质?压力模型、不同易感性模型和优势敏感性模型是当前有关基因?环境交互作用的三种代表性理论模型。素质?压力模型认为“近墨者黑”或“出淤泥而不染”, 优势反应敏感性模型认为“近朱者赤”, 而不同易感性模型则兼收并蓄, 认为某些个体近墨则黑, 近朱则赤。检验上述模型的现实有效性是当前基因?环境交互作用研究领域的热点问题之一。概观而言, 分组回归和分层回归是常用的传统检验方法, 显著性区域分析法和新参数回归模型法则是新近兴起的。未来研究需要进一步探索三种模型的领域特殊性、种族差异等问题, 检验这些模型的方法也有待改善。 相似文献
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Effects of harsh parenting and positive parenting practices on youth aggressive behavior: The moderating role of early pubertal timing
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This project examines associations between childhood sexual abuse (CSA) and two dimensions of impulsivity (sensation seeking and premeditation), and tests whether CSA-personality associations are moderated by the DRD4 exon III VNTR polymorphism. Sample 1 is from a longitudinal study of university students measured at 10 waves over ages 18–24 years (n = 500). Sample 2 is from a national sample of young adult sibling pairs, ages 18–24, from the National Longitudinal Study of Adolescent Health (n = 2559). In both samples, CSA was associated with elevated sensation seeking. In Sample 1, the association between CSA and sensation seeking was moderated by DRD4 genotype; this gene × environment interaction effect, however, was not replicated in Sample 2. Results suggest new avenues for research on CSA in the area of normal-range personality variation. 相似文献
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AbstractThe links between Reactive Attachment Disorder (RAD) and temperament received relatively little research attention, in spite of their clinical and social relevance. Children with RAD sustain disproportionate burdens of early adversity related to their caregiving environment. However, there seem to be important individual differences in susceptibility to adversity, since only a small number of children show signs of RAD. Based on the work of Zeanah and Fox, this review aims to bring new insights to this relevant clinical issue in light of recent research. A differential susceptibility hypothesis will be considered as a promising and innovative approach toward a further understanding of the links between temperament and RAD. 相似文献
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该研究旨在编制情绪感染问卷并探讨问卷的信度与效度,问卷以Doherty编制的《情绪感染问卷》(the emotional contagion scale)作为蓝本,删除了不适合东方文化的项目,增加了符合中国人的情绪情境和展现情绪方式的项目,经过预测修订后,最终问卷包含5个维度25个项目,正式施测共回收747份有效问卷,并对数据进行了信效度检验。结果表明,探索性因素分析KMO为0.802,总问卷的标准化的Cronbach’sα系数为0.852,项目分析表明项目的鉴别指数D值在0.340~0.479之间,验证性因素分析具有较好的模型拟合度,问卷的重测信度与效标关联效度均达到显著水平。情绪感染问卷的信效度均达到了测量学的要求。 相似文献
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The aim of the current study was to examine the antecedents of susceptibility to pseudoscientific information. Participants were asked to assess their perceived probability of and familiarity with statements containing popular science misconceptions and pseudoscientific claims, which were fabricated for the study. Measures of scientific literacy, moral inclinations, need for closure, and a set of additional variables were collected. Analysis of the results showed that susceptibility to known pseudoscientific theories predicted falling for novel unwarranted claims. Scientific literacy strongly predicted lower pseudoscience susceptibility of all types. Finally, participants' moral inclinations were found to be a strong predictor of different types of pseudoscientific statements. 相似文献
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