The Dumbledore Hypothesis of Cognitive Aging

ABSTRACT— Cognitive aging is often characterized as a process in which two competing forces determine individual development: a genetically driven senescence process that engenders declines in mental mechanics; and an accumulation of life experience that augments cultural, pragmatic, and knowledge-based competence. The considerable variability in the level and rate of change in complex intellectual activities (e.g., language understanding) is often accounted for in terms of individual differences in abilities associated with these forces. I argue that choice in how effort is allocated may be an essential determinant of cognitive change over the life span—both directly, in the form of attentional engagement, and indirectly, as it sculpts neural substrates that give rise to component abilities.     

轻度认知损伤的语义记忆研究述评

轻度认知损伤（Mild cognitive impairment,MCI）是介于正常老化与痴呆之间的过渡阶段,表现为与年龄和教育程度不相称的认知功能减退。本文回顾了近期有关MCI语义记忆的研究,分析比较了各研究的实验任务及结果,得出MCI患者存在一定程度的由多种原因造成的语义记忆损伤,语义记忆测验对MCI的早期筛查和转归预测有重要作用。最后指出将来的研究需要将包括语义记忆成分在内的多种认知测验相结合,以便及早发现有可能发展为痴呆的危险个体并开展相应干预。     

前临床期痴呆的认知特征：当前研究进展和未来研究展望

在这篇文章中, 我将讨论从正常老化到痴呆, 这一通常被称为痴呆前临床阶段的认知功能的转变。研究表明, 阿尔茨海默症和血管性痴呆病人在临床确诊之前的几年中, 会出现明显的认知损伤。早期最突出的损伤存在于情节记忆、加工速度以及执行功能。这些功能性损伤与神经生物学研究证实的边缘系统和新皮层区存在多重损伤是相一致的。虽然早在临床诊段之前, 病人组和控制组的平均成绩存在巨大差异, 但同时这两组测试成绩的分布在很大程度上是重叠的。寻求降低这种重叠度的方法是未来研究的一个重要任务。这有可能通过将认知的和其他指标(如基于脑的、基因的、临床的、社会的)相结合构建预测模型来实现。此外, 在未来研究中以下三方面也是急需考虑问题: (a) 找出在 前临床期间认知功能急速下降的时间点: (b) 评估从前临床到临床诊断变化速率中存在的个体差异; (c) 确定特定因素与随后发生的痴呆之间的关联强度是如何随时间向临床确诊推进而逐渐变化的。     

保留的跨通道启动与老化：对于近期观点的总结

通道内重复启动的研究提示老年人内隐记忆未受损, 这不只体现在视觉通道上还包括其他感觉通道(例如触觉、听觉和嗅觉)。然而很少有研究考察启动任务是否具有通道特异性。在以年轻人为被试的研究中发现跨通道迁移(视觉到触觉和触觉到视觉)和通道内迁移(视觉到视觉, 触觉到触觉)具有相似性。一项最近的研究进一步探索老年人在跨通道启动任务上是否受损。结果显示视觉和触觉间的跨通道启动在年轻被试和老年被试上都是保留的且具有对称性。并且, 对于自然声响、图片的通道内和跨通道启动任务随着年老化发展仍旧保留。这些行为结果和其它最近神经科学结果显示跨通道启动发生于枕叶后纹状皮层区, 而这一区域在老年人中未损坏。这一领域未来的研究方向包括利用不同知觉通道间、利用熟悉的和新异的刺激并结合行为的和脑成像的方法, 通过设计完善的跨通道启动来研究正常老人与阿尔兹海默病人, 还包括将设计得完善的启动任务包括在用于改善老年人记忆功能的项目中。     

年老化与文本理解

年老化与文本理解的研究表明,老年人在表层形式和文本基础两个低水平表征上的理解和记忆能力下降,而在情境模型的建构和提取、更新等加工过程中都没有发现由于年老化引起的能力下降。在介绍这些研究的基础上,从情境模型与另两个低水平加工的不同特点和老年人自身的特殊性两个方面分析了老年人在不同层次表征水平加工能力差异的原因。对情境模型水平加工能力保持的潜在机制及相关的影响因素,以及如何弥补在低水平加工中认知能力因年龄而产生的下降等问题还需要进行探讨     

成功老龄化的SOC模型研究综述

本文简单回顾了关于成功老龄化研究的历史,综合阐释其定义及指标,并引入Baltes经典成功老龄化的SOC模型,详细介绍它的原理及其组成部分——选择、优化和补偿,并概述它对老龄化满意度的积极影响,最后总结了该领域研究中尚存的问题。     

The Kindness of Mothers: Ideals and Practice of Buddhist Filial Piety

This article introduces a Buddhist Sutra about filial piety. The Sutra has been widely recited, upheld, and endeared by East Asian people for centuries. It teaches the importance of understanding parents' kindnesses, particularly the mother's, and repaying their kindnesses. It explains the difficulty of repaying parents' kindnesses, unfilial behaviors of children, the mystical hell into which unfilial children are doomed to fall, and the way in which they can repay their parents' kindnesses. The mother (woman), aging, and related issues in Buddhism are discussed.     

A Debate on the Ethics of Aging: Does the Concept of Autonomy Provide a Sufficient Framework for Aging Policy?

This article presents a debate on the issue of autonomy in aging policy held at the 1994 annual meeting of the American Society on Aging held in San Francisco, California. Harry R. Moody, director of the Institute for Human Values in Aging at Hunter College, supports a reconceptualized notion of personal autonomy which focuses on issues of power, theory, and practice, and finds conflicts between autonomy and justice in the lived world of the elderly and disabled. In aging policy, he promotes an emphasis on social movements such as Hospice rather than on autonomy of individuals. He suggests alternatives to extreme paternalism or complete autonomy, such as a communicative ethics approach. Larry Polivka, director of the Florida Policy Exchange Center on Aging at the University of South Florida, affirms that policy for the aging and disabled should be based ona commitment to autonomy. He describes an integrated model for long-term care that places autonomy first and includes features of communicative ethics and the negotiated consent and virtues models of ethics.     

Stress and Immunity: Age Enhances the Risks

A competent immune response is central to good health. There is good evidence that both aging and psychological stress can dysregulate immune function, resulting in changes in various aspects of the immune response that are large enough to have consequences for health. Older adults appear to show even greater immunological impairments associated with stress or depression than younger adults. Thus, the data suggest that aging interacts with stress and depression to enhance risks for morbidity and mortality among older adults.