"脑死亡=死亡"生物医学定律的逻辑论证

心脏具有顽固自律性、可多次复苏性、功能可人工替代性、可多次置换性四大特点,因而已失去作为死亡判定权威器官的地位.而大脑由于具有统领性、损坏后不可恢复性、功能不可替代性、全脑不可置换性四大特点,已替代心脏成为死亡判定的靶器官."脑死亡=死亡"在相当长时期内都将是一个严格的科学定义.     

The role of structural consistency between categories and attributes in hierarchical category learning

This study investigated how consistency between categories and attributes determines attribute selection in hierarchical category learning. Participants learned six categories for which number and color were equally relevant attributes, followed by a transfer task, to test which attribute was used. Before that, half of them learned embedding higher-level categories for which numbers were likely to be used. Orthogonal to this factor, the hierarchical structure was made explicit for half of them by category labels. The results showed that participants used numbers in the prior learning, but that the use of numbers was inhibited in the subsequent six-category learning task. However, this inhibitory effect was reduced when the hierarchical structure was explicit. The pattern of results suggests that attribute selection is determined by structural consistency between categories and attributes, not by a prior use of an attribute.     

Storytellers and Scenario Spinners: Some Reflections on Religion and Science in Light of a Pragmatic, Evolutionary Theory of Knowledge

Asserting that both scientists and religious thinkers are involved in telling stories about the past and spinning scenarios about the future, I first compare and contrast the purposes of scientific and religious storytelling. Then, in light of some recent work on brain and language evolution, I offer a possible story about how humans might have become storytellers. Finally, I discuss how religious stories might be evaluated pragmatically and even scientifically by developing Lakatosian-type research programs.     

The association between the behavior rating inventory of executive functioning and cognitive testing in children diagnosed with a brain tumor

Pediatric brain tumor survivors (PBTS) suffer from cognitive late effects, such as deteriorating executive functioning (EF). We explored the suitability of the Behavior Rating Inventory of Executive Function (BRIEF) to screen for these late effects. We assessed the relationship between the BRIEF and EF tasks, and between the BRIEF-Parent and BRIEF-Teacher, and we explored the clinical utility. Eighty-two PBTS (8–18 years) were assessed with EF tasks measuring attention, cognitive flexibility, inhibition, visual-, and working memory (WM), and with the BRIEF-Parent and BRIEF-Teacher. Pearson’s correlations between the BRIEF and EF tasks, and between the BRIEF-Parent and BRIEF-Teacher were calculated. The BRIEF-Parent related poorly to EF tasks (rs < .26, ps > .01), but of the BRIEF-Teacher the WM-scale, Monitor-scale, Behavioral-Regulation-Index, and Meta-cognition-Index, and Total-score (rs > .31, ps < .01) related significantly to some EF tasks. When controlling for age, only the WM scale and Total score related significantly to the attention task (ps < .01). The inhibit scales of the BRIEF-Parent and BRIEF-Teacher correlated significantly (r = .33, p < .01). Children with clinically elevated scores on BRIEF scales that correlated with EF tasks performed worse on all EF tasks (ds 0.56–1.23, ps < .05). The BRIEF-Teacher Total and Index scores might better screen general EF in PBTS than the BRIEF-Parent. However, the BRIEF-Teacher is also not specific enough to capture separate EFs. Solely relying on the BRIEF as a screening measure of EFs in BPTS is insufficient. Questionnaires and tasks give distinctive, valuable information.     

Development and preliminary validation of the Paediatric Awareness Questionnaire for children and adolescents with traumatic brain injury

There is a lack of validated measures for assessing self-awareness of deficits after pediatric traumatic brain injury (TBI). The current study aimed to develop and examine the psychometric properties of the Paediatric Awareness Questionnaire (PAQ), and investigate factors related to self-awareness. The PAQ was administered to 32 children aged 8–16 years with mild to severe TBI (72% male, M age = 11.75, SD = 2.9), their parents, and treating clinicians, and to 32 age- and gender-matched typically developing controls and their parents. Children with TBI and their parents also completed the Knowledge of Injury Checklist (KIC), and parents completed the Depression Anxiety and Stress Scale 21. The PAQ was found to have fair to excellent (α = .79–.97) internal consistency for all versions across both groups and good concordance between parent and clinician total scores (ICC = .78). There was also evidence of convergent validity between the PAQ and KIC for both child (r = ?.45, p < .05) and parent ratings (r = ?.66, p < .001). Poorer self-awareness was significantly related to younger age at injury for the TBI group and lower parental education for the total sample. ANCOVA identified that children with TBI demonstrated significantly poorer awareness than controls after controlling for parental education. Children with TBI typically overestimated their functioning compared to their parents, whereas typically developing children tended to rate their functioning lower than their parents. These findings provide preliminary support for the reliability and validity of the PAQ for assessing self-awareness after pediatric TBI.     

SEM Based CARMA Time Series Modeling for Arbitrary N

This article explains in detail the state space specification and estimation of first and higher-order autoregressive moving-average models in continuous time (CARMA) in an extended structural equation modeling (SEM) context for N = 1 as well as N > 1. To illustrate the approach, simulations will be presented in which a single panel model (T = 41 time points) is estimated for a sample of N = 1,000 individuals as well as for samples of N = 100 and N = 50 individuals, followed by estimating 100 separate models for each of the one-hundred N = 1 cases in the N = 100 sample. Furthermore, we will demonstrate how to test the difference between the full panel model and each N = 1 model by means of a subject-group-reproducibility test. Finally, the proposed analyses will be applied in an empirical example, in which the relationships between mood at work and mood at home are studied in a sample of N = 55 women. All analyses are carried out by ctsem, an R-package for continuous time modeling, interfacing to OpenMx.     

Effects of aging on action-intentional programming

Background: Action-intentional programs control “when” we initiate, inhibit, continue, and stop motor actions. The purpose of this study was to learn if there are changes in the action-intentional system with healthy aging, and if these changes are asymmetrical (right versus left upper limb) or related to impaired interhemispheric communication. Methods: We administered tests of action-intention to 41 middle-aged and older adults (61.9 ± 12.3 years). Results: Regression analyses revealed that older age predicted a decrement in performance for tests of crossed motor response inhibition as well as slower motor initiation with the left hand. Conclusion: Changes in action-intention with aging appear to be related to alterations of interhemispheric communication and/or age-related right hemisphere dysfunction; however, further research is needed to identify the mechanisms for age-related changes in the brain networks that mediate action-intention.     

Pathways to violence propensity: Results from a two-wave study of young males in urban South Africa

The aim of this study was to model pathways to violence propensity and violent behaviour among boys and young men in a high-violence community in South Africa. To that end, 284 young males (11 to 23 years old) from Khayelitsha, Cape Town self-reported risk for engagement in interpersonal violence and criminality; including within family, peer, and school domains, over a 12 month period. In Structural Equation Modelling, a pathway emerged through which an unstable home environment, influenced by deprivation and violence, affects the quality of parenting. In turn, early deviant associations and attitudes toward violence and gangs are cultivated and may have a deleterious effect on schooling, resulting in greater future substance abuse, greater violence propensity, and offending. These findings support the life course perspective approach, emphasising turning points and human agency in the aetiology of violence.     

基于结构方程模型的有调节的中介效应分析

有调节的中介模型是中介过程受到调节变量影响的模型。指出了目前有调节的中介效应分析普遍存在的问题：当前有调节的中介效应检验大多使用多元线性回归分析,忽略了测量误差;而基于结构方程模型(SEM)的有调节的中介效应分析需要产生乘积指标,又会面临乘积指标生成和乘积项非正态分布的问题。在简介潜调节结构方程(LMS)方法后,建议使用LMS方法得到偏差校正的bootstrap置信区间来进行基于SEM的有调节的中介效应分析。总结出一个有调节的中介SEM分析流程,并有示例和相应的Mplus程序。文末展望了LMS和有调节的中介模型的发展方向。