胃癌辅助化疗的选择和应用

局部进展期胃癌手术后是否给予全身辅助化疗以及关于标准方案的临床研究,一直是临床关注的热点问题,对ⅡB期以上的进展期胃癌术后给予辅助治疗已经成为共识,但对于采用何种方案作为标准方案尚缺乏循证学依据,而且东西方医学界的意见存在较大的争议,我们一方面期待具有更高级别证据的临床研究结果,另一方面在现有证据下对胃癌术后进行最大程...     

动态磁共振成像在早期乳腺癌诊断中的临床研究

评价动态增强磁共振成像在早期乳腺癌诊断中的价值。随机选取2008年10月到2011年6月本院83例经B超或B超联合钼靶检查阴性的中青年女性行乳腺MRI检查,对MRI发现可疑结节病灶的患者进行手术活检,通过病理诊断来评价MRI在诊断早期乳腺癌的准确性和临床应用价值。83例中青年女性中,发现病变7例（8．4％）,癌前改变4...     

乳腺癌治疗的新视野与医院管理的改革

阐述了乳腺癌治疗方法的发展过程,包括外科、内科、放疗科、生物治疗。乳腺外科由扩大根治手术发展到保乳手术,由局部的病变认识到全身病变。内科治疗与外科配合,与内分泌的治疗相结合,又有大量的新药出现,使内科治疗从姑息性治疗走向根治性治疗。加上放疗技术和放疗设备的进步,靶向治疗药的层出不穷使人们越来越认识到乳腺癌是需要综合性治疗,从而推论到对医院管理制度及方法的探讨。认为医院需要建立正确的核心价值观即与患者携手同行让生命不再灰色,表现出更多的人文关怀,利用高科技为患者提供个性化的综合治疗,并付以相应的管理制度。     

麻醉科医师在晚期癌痛治疗中的作用

1986年WHO推出的“三阶梯”癌痛镇痛用药方案目前在临床工作中存在误区。麻醉科医师必须明确在晚期癌痛治疗转变中的责任和义务:具有专业能力、保健与防病能力,消除使用阿片类药物成瘾恐惧症;团队协作能力、新技术的评估能力,实行跨学科综合姑息保健;遵循生物心理社会医学模式,对晚期癌痛患者实施人文关怀。不仅会运用药物和医疗技术手段,还需配合心理和社会方面进行全面的诊疗,更好地为患者服务。     

癌症生存者生活质量及影响因素的调查分析

探讨不同癌症生存者的生活质量状况及其影响因素,对癌症部位、患病时间不同的癌症生存者148名,采用生活质量问卷(EORTCQLQ-30)进行测量。结果:不同年龄组之间RF、EF、SL和FI得分有统计学差异;男女患者在SF、AP和QOL方面有统计学差异。不同文化程度患者之间PF、RF、FA、NV和AP有统计学差异。患病时间与总体生活质量(QOL)之间相关性有统计学意义。不同种类癌症患者之间SF、DY、AP得分有统计学差异。有无复发或转移、是否接受手术治疗以及目前是否正在进行化疗均会对癌症生存者的生活质量产生影响。结论:人口学特征及疾病等因素均会不同程度的影响到癌症生存者的生活质量,提示医务人员应根据癌症生存者不同的特点进行有的放矢的治疗和护理,在延长其生存时间的同时也应注意提高其生活质量。     

晚期癌症与安乐死的探讨

对136例无救治希望的晚期癌症患者及家属进行问答式调查,旨在分析安乐死在晚期癌症患者中实施的可行性。结果,只有2.2%的患者欲选择安乐死,家属均不选择安乐死;95.6%的患者和97.8%的家属选择临终关怀或姑息治疗。因此,安乐死难以为人们所接受。     

Health Behaviors of Childhood Cancer Survivors: What We’ve Learned

There has been a dramatic increase in the number of childhood cancer survivors due to improved cancer treatments. However, these survivors are at risk for numerous late-effects as a result of their cancer therapy. Engaging in health-protective behaviors and limiting risky health behaviors are vitally important for survivors given their increased risks and physical late-effects. For this paper, we systematically reviewed the literature on childhood cancer survivors’ health behaviors by searching for published data and conference proceedings using computerized databases and references, and summarized these results. We examined the literature describing the prevalence of a variety of health behaviors among survivors, identifying significant covariates, and describing health behavior interventions. Finally, we provided research recommendations and discussed an ongoing study designed to address some of the limitations in the existing literature. The research to date is limited and recommendations for future studies are outlined.     

Family history in ovarian cancer referral population

In order to determine the incidence of familial and hereditary ovarian cancer in a referral patient population, we conducted a retrospective study of 44 patients from a consecutive set of 62 patients treated for ovarian carcinoma at the Gynecologic Oncology Clinic at the Richland Memorial Hospital Center for Cancer Treatment and Research between January 1, 1993 and December 31, 1993. In our study of the referred patients, only two (4.55%) reported a history of at least one first-degree relative also being affected with ovarian cancer. However, 13 patients (29.55%) reported a family history consistent with one of the hereditary ovarian cancer syndromes. In addition to having a suggestive family history, these 13 families demonstrated several cardinal features of hereditary cancer syndromes including early onset, bilaterality, multiple primary tumors, and transmission. Race was the only significantly different demographic factor between the hereditary and sporadic ovarian cancer groups. All 13 patients who appeared to have a hereditary form of cancer were Caucasian.     

人格特征对胃癌发病的影响

使用Ｃ型行为特征问卷、生活事件量表和ＲＢＣ－Ｃ_（３ｂ）Ｒ、ＲＢＣ－ＩＣ、ＲＣＩＡ、ＣＩＣ和Ｃ_３等免疫功能的检测,调查和检测了３０名胃癌患者和５０名健康者。结果表明：（１）胃癌组比健康组在焦虑、抑郁、愤怒内泄、控制等方面得分高,在愤怒外泄、乐观、社会支持等方面得分低;（２）胃癌患者在确诊前８年内有７６％的患者遇到生活事件,在确诊前３年内有６２％的患者遇到生活事件;（３）胃癌组ＲＢＣ－Ｃ_（３ｂ）Ｒ含量低,ＲＣＩＡ含量和ＣＩＣ水平上升。初步结论：胃癌的发生与患者的一些行为特点有关,主要是抑郁并不表达愤怒;生活事件可作为应激源诱发胃癌;其机制可能与免疫功能有关。