The use of genetic test information in insurance: The argument from indistinguishability reconsidered

In the bioethical literature, discrimination in insurance on the basis of genetic risk factors detected by genetic testing has been defended and opposed on various ethical grounds. One important argument in favour of the practice is offered by those who believe that it is not possible to distinguish between genetic and non-genetic information, at least not for practical policy purposes such as insurance decision-making. According to the argument from indistinguishability, the use of genetic test information for insurance purposes should be permitted, because genetic test information is no different from non-genetic medical information in any relevant respect, therefore it would be inconsistent to prohibit the former whilst permitting the latter. This paper discusses and defends this argument and suggests a new, more tenable foundation.     

Checking the Assumptions of Rasch's Model for Speed Tests

Two new tests for a model for the response times on pure speed tests by Rasch (1960) are proposed. The model is based on the assumption that the test response times are approximately gamma distributed, with known index parameters and unknown rate parameters. The rate parameters are decomposed in a subject ability parameter and a test difficulty parameter. By treating the ability as a gamma distributed random variable, maximum marginal likelihood (MML) estimators for the test difficulty parameters and the parameters of the ability distribution are easily derived. Also the model tests proposed here pertain to the framework of MML. Two tests or modification indices are proposed. The first one is focused on the assumption of local stochastic independence, the second one on the assumption of the test characteristic functions. The tests are based on Lagrange multiplier statistics, and can therefore be computed using the parameter estimates under the null model. Therefore, model violations for all items and pairs of items can be assessed as a by-product of one single estimation run. Power studies and applications to real data are included as numerical examples.     

Trajectories of Peer-Nominated Aggression: Risk Status,Predictors and Outcomes

Developmental trajectories of peer-nominated aggression, risk factors at baseline, and outcomes were studied. Peer nominations of aggression were obtained annually from grades 1 to 3. Three developmental trajectories were identified: an early-onset/increasers trajectory with high levels of peer-nominated aggression at elementary school entry and increasing levels throughout follow-up; a moderate-persistent trajectory of aggression in which children were characterized by moderate levels of physical aggression at baseline; and a third trajectory with stable low levels of aggression. Children following the early-onset/increasers trajectory showed physical forms of aggression at baseline. Male gender and comorbid attention deficit/hyperactivity problems, oppositional defiant problems and poor prosocial behavior plus negative life events predicted which children would follow the early-onset/increasers trajectory of aggression. The outcomes associated with the early-onset/increaser children suggest high risk for chronically high levels of aggressive behavior.     

Effect of Children's Perceived Rejection on Physical Aggression

This study investigated whether the perception of self as socially rejected might contribute to increased physical aggression among elementary-school children. It was hypothesized that physically aggressive children would become more physically aggressive over time if they perceived that they were rejected and tended to blame peers for social failure experiences. Third-grade boys and girls (n = 941) were assessed in the Fall and Spring of the school year. Peer-report data on physical aggression and social preference were collected, along with self-report data on perceived rejection and attributions for social failure experiences. Results for boys were consistent with hypotheses, whereas the results for girls revealed a different pattern of relations. These results constitute prospective evidence that children's self-perceptions of social rejection can uniquely influence externalizing behavior. Results are discussed in terms of mechanisms that might mediate the relation between perceived rejection and physical aggression.     

Measurement of Cruelty in Children: The Cruelty to Animals Inventory

Cruelty to animals may be a particularly pernicious aspect of problematic child development. Progress in understanding the development of the problem is limited due to the complex nature of cruelty as a construct, and limitations with current assessment measures. The Children and Animals Inventory (CAI) was developed as a brief self- and parent-report measure of F. R. Ascione's (1993) 9 parameters of cruelty. The CAI emerged as a reliable, stable, and readily utilized measure of cruelty using parent and child reports. Children (especially the older children) reported higher rates of cruelty than their parents and boys reported more cruelty than girls. Self- and parent-reports showed good convergence with independent observations of cruelty versus nurturance during free interactions with domestic animals. The results indicate that cruelty to animals can be reliably measured using brief child and parent report measures.     

Advancing our understanding of intergenerational continuity in antisocial behavior

This commentary reviews the major findings of this set of 4 papers on intergenerational continuity in antisocial behavior; it identifies strengths and remaining challenges, and discusses potential policy implications of the research. As a group, these researchers have raised the methodological bar for future work in this area, using prospective designs with multiple informants and methods to test the influences of G2 parenting and adolescent antisocial behavior in mediating continuity between G1 parenting and G3 early disruptive behavior. The pattern of findings is discussed with respect to gender of G2 and social context. The inherent challenges of conducting intergenerational research are also highlighted, within the context of offering recommendations for improving future intergenerational investigations and their feasibility.     

Functional recovery of skilled forelimb use in rats obliged to use the impaired limb after grafting of the frontal cortex lesion with homotopic fetal cortex

The long-term effect of transplanting embryonic frontal cortex into a unilateral frontal cortex lesion has been studied in adult rats. Before surgery, activity in an open field, muscular strength of both forelimbs, and performance in a paw-reaching-for-food task were scored in 26 rats. In 21 animals a unilateral cortex lesion was then made in the forelimb motor area of the hemisphere contralateral to the preferred paw in the paw-reaching-for-food task, while the other 5 animals were sham-operated. On retesting, the lesion animals changed the preferred paw. A solid homotopic transplant of embryonic tissue (embryonic day 17) was then placed in the lesion cavity in 11 of the lesion rats. Three months later neither lesion alone nor lesion plus transplantation affected open field behavior and muscular strength, but the lesion permanently affected performance in the paw-reaching-for-food task, as shown by a change of preferred paw and a functional deficit in the paw contralateral to the lesion. Transplantation ameliorated the deficits caused by the lesion, but this was only evident when animals were forced to reach with the paw contralateral to the lesion plus transplant. The behavioral results were independent of the size of the lesion and graft. Connections between graft and host tissue were studied by means of the fluorescent tracer 1,1'-dioctadecyl-3,3,3'3'-tetramethylindocarbocyanine perchlorate (DiI). A dense array of labeled fibers was found in the host cortex adjacent to the transplant. The results suggest that functional recovery depends on grafting but is only evident when the animal is obliged to use the affected limb.