血管内皮生长因子与结直肠癌的研究

血管内皮生长因子(vascular endothelial growth factor,VEGF)是一高度特异作用于内皮细胞的糖蛋白,是目前发现的最重要的肿瘤血管生长因子之一.结直肠癌的生长、侵袭和转移与血管内皮生长因子有密切的关系,VEGF在结直肠癌治疗中的作用日益突出.本文就VEGF的功能、在结直肠癌中的表达和治疗的作用作一综述.     

Daily mood patterns and bulimic behaviors in the natural environment

Objective

Negative affect has been purported to play an important role in the etiology and maintenance of bulimic behaviors. The objective of this study was to identify daily mood patterns in the natural environment exhibited by individuals with bulimia nervosa and to examine the relationship between these patterns and bulimic behaviors.

Method

One hundred thirty-three women aged 18-55 meeting DSM-IV criteria for bulimia nervosa were recruited through clinical referrals and community advertisements. Ecological momentary assessment was used to collect multiple ratings of negative affect, binge eating and purging each day for a two-week period using palmtop computers. Latent growth mixture modeling was used to identify daily mood patterns.

Results

Nine distinct daily mood patterns were identified. The highest rates of binge eating and purging episodes occurred on days characterized by stable high negative affect or increasing negative affect over the course of the day.

Conclusions

These findings support the conclusion that negative mood states are intimately tied to bulimic behaviors and may in fact precipitate such behavior.     

Acute systemic fibroblast growth factor-2 enhances long-term memory in developing rats

Recent findings have provided much insight into the mechanisms underlying long-term memory formation, and it is now known that long-term memory depends on the activation of a molecular cascade that culminates with structural changes in the brain. However, little is known about the signals that give rise to or regulate these structural changes. In this article we propose that fibroblast growth factor-2 (FGF2), a mitogen for several cell types, may be one of the molecular signals critically involved in the structural changes underlying long-term memory. If FGF2 is part of the signalling cascade involved in long-term memory, then increasing the activation of FGF2 should facilitate memory. In Experiments 1 and 2, we demonstrated that systemic injection of FGF2 (20 ng/g of body weight) facilitated memory for contextual fear in 16, 19, and 22 day old male Sprague Dawley rats. Experiment 3 demonstrated that the observed facilitation of memory was not due to FGF2 increasing rats’ sensitivity to footshock. These results implicate FGF2 as a possible molecular signal in long-term memory, and further, illustrate a novel means of enhancing memory.     

The rise of the child's voice; the silencing of the spiritual voice

In recent years the notion of the child's voice has gained prominence, particularly influenced by the United Nations Convention on the Rights of the Child (UNCRC) in 1989 which outlined rights for children on an international scale. Many countries, including the UK, subsequently legislated for the child's voice to be heard in a variety of arenas including the education system. Despite the concept of the child's voice now being firmly established within schools in England, this paper argues that one aspect of their voice is not being heard: their spiritual voice. Drawing on evidence from research, this paper proposes that a variety of factors have culminated in a tendency towards a silencing of the child's spiritual voice. It argues that this silencing is an important one which should be acknowledged and rectified if educators in all schools are to treat the concept of the whole child seriously, and fully value their well‐being.     

A qualitative exploration into how the use of prayer in counselling and psychotherapy might be ethically problematic

Aim: This research article contributes to the debate on the value and limitation of the use of spiritual strategies, like prayer, in counselling (Foskett & Lynch, 2001) by disseminating the insights that were gained from a qualitative study of mainstream counsellors whose work includes prayer. Method: Participants were 19 British Association for Counselling and Psychotherapy (BACP)‐accredited and Churches Ministerial Counselling Service (CMCS)‐approved counsellors who use prayer in their practice. They were interviewed, and the data were analysed using Interpretative Phenomenological Analysis. Results: The data reveal that counsellors who use prayer are aware that ethical problems may be encountered: if prayer changes the way that the counsellor is perceived; when using prayer with issues of psychopathology; if the counsellor uses prayer to impose faith on a client; when being professionally held to account; if prayer is used for avoidance or as a defence; if prayer is used to enhance the counsellor's power; if prayer is not part of the client's agenda; if prayer is used routinely; if prayer cannot be challenged; if there is a cultural pressure to pray; and if the prayer method is not matched to the client – but that their concern over potential ethical issues is not of sufficient strength to override their therapeutic use of prayer if facilitated with due care.     

Normative Developmental Trajectories of Aggressive Behaviors in African American,American Indian,Asian American,Caucasian, and Hispanic Children and Early Adolescents

The current 5-year accelerated longitudinal investigation modeled the developmental trajectories of aggressive behaviors in 10,107 predominantly minority (>70%; African American, American Indian, Asian American, and Hispanic) children and early adolescents (Kindergarten through 8th grade, 49% female youth) from lower to lower-middle socioeconomic strata. Based on a two-part latent growth model, findings suggest that the probability and frequency of aggressive behavior use decreases slightly (linear) through the elementary school years and then increases as children move into middle school (quadratic). Though mean level differences were found across ethnic and racial groups, socioeconomic strata, and particularly by sex at initial status, rates of change over time across all groups were invariant. Findings suggest that potential socialization differences, if any, occur pre-Kindergarten in all groups.     

Ambiguity in Our Technical Society

The spiritual situation at the turn of the millennium can be interpreted through Paul Tillich's appropriation of modernity, by analysis of the determinative structures and decisive trends of our age. The methods and organization of industry determine modern society. Spiritually, this situation results in the proliferation of means without ends, the objectification of natural structures, and the reduction of persons to things. Extrapolating from Tillich's analysis, the spiritual situation at the turn of the millennium can be understood as a quasi-religious struggle between the movements of liberal individualism and multiculturalism, both of which lose the sense of ambiguity. The communitarian movement and related interpretations remain the minority voice offering a mediating position.     

入学过渡期高中新生大五人格与主观社会地位变化轨迹的关系：基于潜变量增长模型的分析

为了考察入学过渡期高中新生主观社会地位（subjective social status, SSS）的变化轨迹及人格在其中的作用,本研究对546名高一新生进行了历时4个月的4次追踪测试。基于潜变量增长模型的分析结果显示：（1）SSS呈阶段化线性增长,且个体间差异显著;（2）人格中的外倾性、宜人性、责任心和开放性均能显著预测SSS的初始水平;（3）外倾性、宜人性和神经质对SSS的第一阶段变化速度有显著预测作用。结果表明,SSS会在新生入学后1个月内初步形成,且人格与其变化轨迹有关。     

Moral growth in medical students

Although students bring to medical school a fairly well established value system, the potential for moral growth through the medical school environment and experience is substantial. The educational environment poses a succession of developmental and adaptive tasks to be accomplished. Several of these tasks are discussed here, tasks that are value-laden and involve, directly or indirectly, the interplay of ethical theory and practice. During the past quarter century, the two influences that have had the greatest impact on the moral growth and moral reasoning capacity of medical students have been the incorporation into the medical school curriculum of courses in medical humanities and the admission to medical school of an increasing number of female students. The female students have brought to medical school a level or dimension of moral reasoning (morality as care or responsibility for others) to augment the male students' focus on rights and justice considerations.