Validation of the Portuguese emotion awareness questionnaire for children and adolescents

This study examined the construct and concurrent validity of the Portuguese version of the Emotion Awareness Questionnaire (EAQ) in 302 children and adolescents (mean age 13 years old). The EAQ is a self-report questionnaire that allows for analysis of how youth experience and understand their own and others’ emotions. Participants completed the EAQ along with questionnaires for Worry and Somatic Complaints. Results confirmed the expected six-factor structure, good psychometric properties, and good concurrent validity. The EAQ is a reliable questionnaire, suitable for examining emotion awareness in Portugal.     

The clinical utility of the auditory P300 latency subcomponent event-related potential in preclinical diagnosis of patients with mild cognitive impairment and Alzheimer’s disease

The present meta-analysis investigated the clinical utility of the auditory P300 latency event-related potential in differentiating patients with Alzheimer’s disease (AD), patients with mild cognitive impairment (MCI), and unaffected controls. Effect size estimates were computed from mean P300 latency measurements at midline electrodes between patients and unaffected controls using the random effects restricted maximum likelihood model. The effects of clinical and ERP/EEG methological variables were assessed in a moderator analysis. P300 latency was found to be significantly prolonged in patients with AD (and MCI) compared to unaffected controls. Shortened P300 latencies were observed when comparing patients with MCI to patients with AD. Clinically relevant differences in P300 latency effect sizes were associated with mean age, interstimulus interval, stimulus difference, target frequency, reference electrode, and sampling rate. The meta-analytic findings provide robust statistical evidence for the use of the auditory P300 latency subcomponent as a biological marker of prodromal AD.     

Culture Marker Versus Authority Marker: How Do Language Attitudes Affect Political Trust?

Is public trust in government representatives (i.e., bureaucrats, police, public servants) affected by the language they use? The conventional theory holds that, in a multilingual society, people favor government representatives who speak the listeners' dialects because it indicates a shared cultural identity, that is, the “culture-marker” effect. This article offers an alternative mechanism in which people's attitudes can be affected by the government designating the official language as a marker of political authority. Listeners will then project their respect for the political authority to the government representatives who speak this marker language. This mechanism is named an “authority marker” effect. Using a set of adjusted matched-guise experiments in China, this study examines the culture-marker and authority-marker effects. The results support the authority-marker effect by showing that listeners have significantly more trust in the bureaucrats who speak the official language than in those who speak the dialects of the listeners. The study also finds that this is a unique effect for speakers when they represent the government. Without that political identity, listeners will still respond more positively to speakers of their own dialects.     

Numbsense of shape,texture, and objects after left parietal infarction: A case report

Numbsense is a phenomenon, wherein patients can correctly respond to somatosensory stimuli at a higher rate than expected by chance, but cannot perceive the same stimuli consciously. Previously, numbsense has been reported in tactile localization of stimuli on the patient’s own body. Here, we describe a patient with numbsense that involved touched objects. The patient could not recognize the majority of somatosensory stimuli after left parietal infarction, but could correctly select shape, texture, and object stimuli more frequently than expected by chance.     

Revising,Correcting, and Transferring Genes

Abstract

The distinction between germline and somatic gene editing is fundamental to the ethics of human gene editing. Multiple conferences of scientists, ethicists, and policymakers, and multiple professional bodies, have called for moratoria on germline gene editing, and editing of human germline cells is considered to be an ethical “red line” that either never should be crossed, or should only be crossed with great caution and care. However, as research on germline gene editing has progressed, it has become clear that not all germline interventions are alike, and that these differences make a significant moral difference, when it comes to ethical questions about research, regulation, clinical application, and medical justification. In this paper, I argue that, rather than lumping all germline interventions together, we should distinguish between revising, correcting, and transferring genes, and I assess the consequences of this move for the ethics of gene editing.