Competing interests: The need to control conflict of interests in biomedical research

Individual and institutional conflict of interests in biomedical research have becomes matters of increasing concern in recent years. In the United States, the growth in relationships — sponsored research agreements, consultancies, memberships on boards, licensing agreements, and equity ownership — between for-profit corporations and research universities and their scientists has made the problem of conflicts, particularly financial conflicts, more acute. Conflicts can interfere with or compromise important principles and obligations of researchers and their institutions, e.g., adherence to accepted research norms, duty of care to patients, and open exchange of information. Disclosure is a key component of a successful conflict policy. Commitments which conflict with a faculty member's primary obligations to teaching, research, administrative responsibilities, or patient care also need attention. Institutional conflict of interests present different problems, some of which are discussed in an analysis of an actual problem posed by two proposed clinical trials. This paper is adapted from a lecture presented to a Symposium on Scientific Integrity, Warsaw, Poland, 23 November 1995. Daniel Steiner was Vice-President and General Counsel of Harvard University (1972–92) and in that capacity became familiar with conflict of interest issues. He is currently Counsel to the Boston law firm. Ropes and Gray, and is Adjunct Lecturer in Public Policy at the John F. Kennedy School of Government. Harvard University.     

Social desirability,perceived stress,and PACT ratings in lung transplant candidates: A preliminary investigation

Some aspect of psychosocial criteria is commonly utilized by most transplant programs in assessing candidates' acceptability for transplantation. However, regardless of the assessment methodology, information obtained in pretransplant assessments may be limited given the evaluative nature of the assessment as well as the sensitive nature of the contents. Indeed, transplant candidates may present themselves in a favorable fashion, minimizing any negative traits or psychological dysfunction which they perceive might prevent transplantation. Unfortunately, there are limited data addressing the extent to which transplant candidates may present themselves in an overly positive light. This investigation surveys the prevalence of social desirability in lung transplant candidates as well as its association with self-reports of perceived stress. Further, the relationship between social desirability and interviewer ratings of transplant candidacy is examined. Subjects included 24 patients in end-stage organ failure being evaluated for lung transplant candidacy. Subjects completed the Perceived Stress Scale and a brief version of the Marlowe-Crowne Social Desirability Scale. Additionally, subjects were interviewer-rated on the Psychosocial Assessment of Candidates for Transplantation. Results indicate social desirability is a prevalent phenomenon in lung transplant candidates, with more than half of the sample scoring at or above the 84th percentile on the social desirability measure. Further, self-reports of perceived stress are moderately and inversely associated with social desirability (r=–.55,p .01). Social desirability was unrelated to interviewer-ratings of transplant candidates acceptability (r=.13,p .56). Future research might include larger samples of subjects, other organ transplant candidates, and more detailed assessments of symptom distress.     

How much woe when we go: A quantitative method for predicting culture shock

Culture shock is defined as the confusion and discomfort caused by the conflict in perceived motives and expected behaviors between the home culture and the foreign culture. Several quantitative and graphical methods employing techniques of cluster analysis and similarity mapping are offered for predicting the magnitude of culture shock between pairs of countries using data extracted from Hofstede's 1980–83 studies of national cultural values. Implications for business, politics, and personal stress management are discussed.     

Conversational skill and locus of perception

The present study attempted to identify behavioral skills associated with global perceptions of communication competence and to determine if the relationship between competence and skills varies as a function of perceptual locus. Fifteen dyadic conversations were videotaped. Each interactant rated self and partner and was rated by four observers who viewed each tape. Results indicated that subjects' perceptions of their partners' skills accounted for 87% of the variance in subjects' ratings of partners' competence and 80% of the variance in subjects'self-perceived confirmation. Observers' ratings of subjects' skills predicted 83% of the variance in observers' ratings of subjects' competence. Observers'ratings of subjects'skills were unrelated to subjects' self-rated competence.     

Validation of the Children's Assertive Behavior Scale

Relationships between sociometric indices and scores of 160 elementary-school children on the Children's Assertive Behavior Scale (CABS) were examined to determine whether this instrument differentiates children of varying levels of social competence. Children who obtained either high or low scores on peer nominations of friendship and admiration were identified and compared on CABS passive, aggressive, and assertive scores. Children who scored high on positive peer nominations responded in a significantly less aggressive manner than children who received low scores on such nominations. These effects were observed for the CABS format that consisted of stimulus situations involving adults but not for the form involving peers. With regard to responses toward peers, a significant interaction between sex and sociometric status emerged. These findings suggest the importance of incorporating subject variables such as race and sex as well as assessments of behavior toward both adults and children in isolating and training components of social skill.The authors wish to express their appreciation to Jean Birbilis, Gail Hammersly, Marieta Knopf, and Donna Wadley for their assistance in data collection and analysis.     

The Heterosocial Assessment Inventory for Women: A psychometric and behavioral evaluation

This paper presents a preliminary psychometric and behavioral evaluation of the Heterosocial Assessment Inventory for Women (HAI-W), a novel self-report instrument that evaluates five dimensions that may influence performance in 12 heterosocial situations: likelihood of initiation, anxiety, skillfulness, expectation of outcome, and influence of attractiveness. Study I obtained acceptable reliability and concurrent validity data and described the factor structure of the HAI-W with female college students. Study II found a significant relationship between the HAI-W factors and global ratings of the role-play performances of high- and low-heterosocially competent female college students as rendered by the male confederate, peer judges, and expert judges. The implications of these findings for the multidimensional assessment and facilitation of heterosocial competence are discussed.This study is part of a dissertation submitted to the Department of Psychology, Georgia State University, under the direction of Michael A. Milan. Portions of these data were presented at the Annual Meeting of the Association for Advancement of Behavior Therapy, Los Angeles, 1982.     

The impact of confederate responsivity on social skills assessment

The current investigation examined the degree to which judges' ratings of skill, anxiety, and attractiveness are influenced by the responsivity of the confederate. High-, medium-, and low-skilled subject-pool groupings, as well as self-referred clinical groups, were exposed to either a moderately or a minimally responsive confederate. Results indicated that subjects were rated as more skillful when interacting with a moderately responsive confederate than when interacting with a minimally responsive confederate. Further, there was a groups × condition interaction for anxiety ratings such that both the high- and the medium-skilled groups appeared more anxious under the minimal condition, whereas the low-skilled and self-referred groups did not. Self-referred subjects received significantly lower attractiveness ratings than did the high- or medium-skilled groups. Implications of these results and future directions for research are discussed.This research is based on a M.S. thesis carried out by the first author under direction of the second author.     

Factor analysis of the social performance survey schedule

There are several studies suggesting that the Social Performance Survey Schedule (SPSS) is a reliable and valid measure of social skill. However, the factorial structure of the SPSS has never been examined. In the present study, SPSSs taken by 652 college students were factor analyzed by the method of principal components and the resulting factors were rotated according to the varimax criterion. Separate factor analyses were conducted for men and women. Seven factors, which accounted for a little over a third of the total variance, were retained for each sex. A large general factor labeled Prosocial Competence emerged for both sexes. Beyond this, the factorial solutions for the two sexes tended to diverge, with males showing a large negative factor (Social Offensiveness) and three smaller negative factors and females showing five relatively small negative factors. Suggestions were made concerning additional factor analytic studies of the SPSS and the ways in which derived factors might be used in research and clinical work.This research was supported by funds from the Rutgers University Research Council. Thanks are due to Leona Aiken for her statistical consultation.