Initial responses to the first dose of nicotine in novel smokers: The role of exposure to environmental smoking and genetic predisposition

Background: Sensitivity to initial smoking constitutes an early predictor of the risk of dependence. We investigated the role of exposure to smoking (by parents, siblings, and peers) and reward-related candidate gene polymorphisms (OPRM1 A118G, DRD2 TaqlA and DRD4?bp VNTR) in adolescents’ responses to initial smoking.

Methods: We used cross-sectional survey data and saliva samples from 171 Dutch students who had never inhaled on a cigarette (mean age: 13.9?years). The outcome measure was adolescents’ self-reported responses to initial smoking.

Results: Exposure to peer smoking was associated with increased liking (OR?=?1.74, CI?=?1.13–2.70) and more pleasant sensations (β?=?.21, p?=?.01). Exposure to maternal smoking was associated with less unpleasant sensations (β?=??.20, p?=?.01). Adolescents carrying the G-variant of the OPRM1 A118G polymorphism were more likely to report liking (OR?=?2.50, CI?=?1.09–5.73) and adolescents homozygous for the C-variant of the DRD2 TaqlA polymorphism reported less unpleasant sensations (β?=?.18, p?=?.04).

Conclusion: Although preliminary, these findings suggest that exposure to environmental smoking and polymorphisms in the OPRM1 and DRD2 gene may affect initial sensitivity to nicotine, an early phenotype of the risk of dependence. In the future, collaborative efforts to combine data from multiple studies in meta-analyses are needed to improve accuracy of estimated effects in genetic studies.     

The role of prior quitting experience in the prediction of smoking cessation

Aims: In the Transtheoretical Model (TTM), the preparation stage (as applied to smoking cessation) is defined as planning to quit in the next 30 days plus having quit for at least 24 h in the last year. This study examined the value of prior quitting experience as a stage classification criterion by investigating whether prediction of making a quit attempt differed as a function of prior quitting experience. Participants: One thousand and forty-six participants, all planning to quit in the next 30 days, in a randomised trial of the effectiveness of a telephone counselling and computer-generated tailored advice intervention were followed up at 3 months. Findings: A multivariate predictive model had markedly greater capacity to predict making a quit attempt among participants with prior quitting experience (as defined in several different ways), compared to analyses of the overall sample. A previous attempt of 24 h in the previous month was associated with the greatest difference in prediction. A quit attempt in the previous year (the TTM definition) did not discriminate. Conclusions: Recent prior quitting experience moderated the predictive capacity of some variables that influence smoking cessation. The findings provide some support for a stage model of smoking cessation but not its operationalisation by the TTM.     

Patient role orientations,doctor-patient fit,and visit satisfaction

Abstract

Two studies were conducted using the Patient-Practitioner Orientation Scale (PPOS), an instrument that measures the role orientations of patients. In the first, 297 students responded to a pool of 61 items concerning their attitudes about doctor-patient relationships (e.g., about power-sharing and the importance of physicians' supportiveness). The scale was reduced, and associations between PPOS scores and gender, race, country of origin as well as Health Locus of Control were found. In Study 2, 90 additional students filled out the PPOS, read two doctor-patient scenarios, and rated their satisfaction as if they had been the patient. In one, the physician exhibited a controlling style, and in the other a more open style. As predicted, patient-centered physicians generated higher satisfaction, and patients were most satisfied with a physician whose style matched their own role orientation. These studies suggest the potential usefulness of the PPOS as an indicator of patient attitudes and doctor-patient fit, and as an predictor of visit satisfaction.     

Racial disparities in smoking knowledge among current smokers: Data from the health information national trends surveys

Although African-Americans (Blacks) smoke fewer cigarettes per day than European-Americans (Whites), there is ample evidence that Blacks are more susceptible to smoking-related health consequences. A variety of behavioural, social and biological factors have been linked to this increased risk. There has been little research, however, on racial differences in smoking-related knowledge and perceived risk of lung cancer. The primary goal of the current study was to evaluate beliefs and knowledge that contribute to race disparities in lung cancer risk among current smokers. Data from two separate nationally representative surveys (the Health Information National Trends surveys 2003 and 2005) were analysed. Logistic and hierarchical regressions were conducted; gender, age, education level, annual household income and amount of smoking were included as covariates. In both studies, Black smokers were significantly more likely to endorse inaccurate statements than were White smokers, and did not estimate their lung cancer risk to be significantly higher than Whites. Results highlight an important racial disparity in public health knowledge among current smokers.     

Mood as a resource in dealing with health recommendations: How mood affects information processing and acceptance of quit-smoking messages

Objective: An experimental study tested the effects of positive and negative mood on the processing and acceptance of health recommendations about smoking in an online experiment. It was hypothesised that positive mood would provide smokers with the resources to systematically process self-relevant health recommendations.

Design: One hundred and twenty-seven participants (smokers and non-smokers) read a message in which a quit smoking programme was recommended. Participants were randomly assigned to one of four conditions: positive versus negative mood, and strong versus weak arguments for the recommended action.

Main outcome measures: Systematic message processing was inferred when participants were able to distinguish between high- and low-quality arguments, and by congruence between attitudes and behavioural intentions. Persuasion was measured by participant's attitudes towards smoking and the recommended action, and by their intentions to follow the action recommendation.

Results: As predicted, smokers systematically processed the health message only under positive mood conditions; non-smokers systematically processed the health message only under negative mood conditions. Moreover, smokers’ attitudes towards the health message predicted intentions to quit smoking only under positive mood conditions.

Conclusion: Findings suggest that positive mood may decrease defensive processing of self-relevant health information.     

Perspectives on relapse prevention: An exploratory study

This article explores the hypothesis that factors associated with relapse early in a quit attempt may lose their predictive power over time. Participants were 195 recent ex-smokers calling a telephone Quitline. Quitters were interviewed, then re-interviewed three weeks later to determine outcome (relapse or maintenance of attempt). There was strong evidence for a discontinuity in prediction of outcome between those who quit for less than one week, or who reported at least daily strong urges to smoke and those who quit for more than a week who reported less than daily strong urges to smoke. Several variables, including self-efficacy and scales of positive social and negative affect temptations, reversed predictive value. This study provides evidence of a perspective or stage within the Action stage of the TTM. More work is required to confirm both the findings and the exact nature of the discontinuity point.     

The relative role of nicotine dependence and smoking-related cognitions in adolescents’ process of smoking cessation

The present study evaluates the role of distinct components of nicotine dependence (craving, withdrawal, behavioural dependence) in comparison to smoking-related cognitions (attitudes, perceived social approval, self-efficacy) in adolescent smoking cessation. In the process towards smoking cessation, we distinguish between distinct behavioural transitions, respectively, short-term abstinence, reduction in smoking behaviour and prolonged cessation, to evaluate differences in cessation-related antecedents as a function of varying behavioural outcomes. A total of 850 adolescent smokers (age 14–16) participated in the present study. Smoking behaviour was assessed 1 year after baseline. Results showed that all dependence components had a distinct role in the prediction of behavioural change towards cessation. Furthermore, each behavioural transition was predicted by a distinct set of variables, indicating that contributions of cessation-related factors vary across the course towards cessation. Overall, our findings suggest that smoking-related cognitions are particularly relevant in the initiation of behavioural change, such as short-term abstinence, whereas nicotine dependence, craving in particular, becomes increasingly important in the prediction of maintained behavioural change, such as prolonged cessation. Implications encompass enhanced attention to the multidimensional nature of nicotine dependence and the value of comparing different behavioural outcomes in a comprehensive understanding of cessation-related factors.     

Schizotypal personality traits and attitudes towards Hinduism among Balinese Hindus

The study explored the relationship between schizotypal personality traits and attitude of Hindus towards their faith. A total of 309 Balinese Hindus responded to the Santosh–Francis Scale of Attitude towards Hinduism, the Schizotypal Personality Questionnaire Brief, and a number of external indicators and religious practices. Attitude towards Hinduism, frequency of prayer, and temple attendance had a rather weak positive relationship with each other, while prayer behaviour exhibited negative low-to-moderate relationships with schizotypal traits. A hierarchical multiple linear regression model identified the disorganised elements of schizotypy as the primary predictor of the attitude towards Hinduism. Finally, age showed negative associations with schizotypy and positive ones with Hinduism, while women were less schizotypal and had more positive attitude towards their faith than men. These findings suggest the presence of both underlying cross-faith elements and the strong influence of faith- and culture-specific forces on the relationship between religiosity and schizotypy.     

防艾宣传大学生对艾滋病患者的内隐态度与交往意愿

目的：探讨大学生防艾宣传者对艾滋病患者的内隐态度。方法：采用自编大学生与艾滋病患者交往意愿调查问卷,通过测量获得对艾滋病患者有较高交往意愿的防艾宣传者100名,并随机抽取其中30名作为实验被试,完成了两组内隐联想测验（IAT）。结果：当艾滋病相关词与普通正性词相联以及非艾滋类乙型传染病与普通负性词相联时,其平均反应时低于艾滋病与一般消极性词相联及非艾滋类乙型传染病与普通正性词相联时的反应时;当艾滋病相关词与正性人际词相联以及非艾滋类乙型传染病与负性人际词相联时,其平均反应时与艾滋病和负性人际词相联及非艾滋类乙型传染病与正性人际词相联时的反应时无统计学意义的差异。结论：大学生防艾宣传者对各类传染病患者的内隐交往意愿处于同一水平,但相对于非艾滋类乙型传染病而言,其对艾滋病患者的消极厌恶水平较低。     

Prevalence,Correlates and Perceptions Towards Cigarette Smoking Among Male and Female in School Adolescents (Aged 11–18 Years) in South Africa: Results from the 2008 GYTS Study

The aim of this study was to estimate the prevalence and identify correlates of current cigarette use among 8,470 school-going adolescents (aged 11 to 18 years) in South Africa. A cross-sectional study was carried out in 2008 in South Africa within the framework of the Global Youth Tobacco Survey (GYTS). Overall prevalence of current cigarette smoking was 16.5%. Significantly more males (22.8%) than females (10.5%) were current smokers (p < .001). Cigarette smoking among boys and girls was positively associated with parental and/or peer smoking and greater risk perception, and among girls smoking attitudes variables (having more friends among girls, greater attractiveness of boys and weight change) and various higher exposure to smoking advertising and promotion activities were positively associated with cigarette smoking. However, antismoking advertising and community and family education were positively associated with current smoking, while only having school or community special groups or classes for students who want to stop smoking was protective of smoking. Cigarette smoking and other tobacco use is a significant public health problem in South Africa. Public health efforts aimed at preventing adolescent cigarette/tobacco use should incorporate knowledge on the associated factors related to smoking.