非小细胞肺癌靶向治疗的前途与困惑

靶向治疗是运用抗肿瘤药物靶向性与肿瘤的不同特异性住点结合发生作用从而抑制肿瘤细胞生长的一种治疗手段。针对恶性肿瘤中的非小细胞肺癌,其在临床中取得了一定成效。然而,其中仍存在很多问题。本文针对吉非替尼在非小细胞肺癌中的运用,及其优点和所面临的问题,阐述如何应对完善靶向治疗的挑战。     

The effects of justice motivation on memory for self- and other-relevant events

We examined whether people might distort and selectively remember the past in ways that enable them to sustain a belief in a just world (BJW; Lerner, M. J. (1980). The belief in a just world: A fundamental delusion. New York: Plenum Press). In Study 1, recall of a lottery prize reflected participants’ justice concerns, such that the average lottery amount recalled was lowest when a “bad” versus “good” person won. In Study 2, an unrelated experience of just world threat (versus affirmation) enhanced biased recall of the lottery prize when the winner was undeserving. In Study 3, participants who experienced a fortuitous bad break selectively remembered more bad deeds from their recent past, whereas participants who experienced a good break selectively remembered more good deeds. Study 4 demonstrates that such selective memory biases specifically serve to portray chance outcomes as more fair. Taken together, these findings offer support for the notion that reconstructing and selectively recalling the past can serve to sustain a BJW.     

Distributive Justice for Others,Collective Angst,and Support for Exclusion of Immigrants

Harsh treatment of others can reflect an underlying motivation to view the world as fair and just and also a dispositional tendency to believe in justice. However, there is a critical need to refine and expand existing knowledge, not only to identify underlying psychological processes but also to better understand how justice may be implicated in support for exclusionary policies. Across two studies, we show that support for policies that restrict immigrants is exclusively associated with thoughts about fair outcomes for other people (distributive justice for others). In Study 1, Americans' dispositional tendency to believe in distributive justice for others was associated with greater support for a policy proposing to further restrict immigrant job seekers' capacity to gain employment in the United States. In Study 2, we experimentally primed thoughts about justice in a sample of U.S. police officers. Support for a policy that mandated stricter policing of illegal immigration was strongest among officers who first thought about fair outcomes for other people, relative to other unique justice primes. Across both studies, distributive justice for others was associated with greater collective angst—perceived threat towards the future existence of Americans. Moreover, collective angst mediated the link between distributive justice for others and support for restrictive policies. Overall, this research suggests that thoughts about distributive justice for others can especially diminish compassion towards immigrants and other underprivileged groups via support for exclusionary policies. In addition, merely thinking about distributive justice for others may be sufficient to amplify social callousness.     

应重视对马克思主义人生观的理论研究

马克思主义的人生观和世界观在马克思主义的历史唯物主义中是统一的。历史唯物主义明确反对从“抽象的人”、“人的当下存在”出发理解人生的有关问题,但这并不一定意味着坚持历史唯物论就要排斥从个体生命的视角研究人生的问题。我们的马克思主义理论研究和建设工作,应重视对马克思主义人生观理论的发掘和整理,为社会主义精神文明建设和和谐社会的构建作出贡献。     

灾区民众的公正观与幸福感及其与非灾区的比较

作为公德的社会公正与作为私情的个人幸福,是个体作为社会成员的两个方面,二者在逻辑上是统一的,以往的心理学研究也证实了这一点,但在低标准下,二者却可能出现分离。本研究探讨了灾区民众的公正观和幸福感及其与非灾区的对比,以及中国本土文化背景下二者的关系。本研究发现,与非灾区相比,处在灾区的民众持有更高的公正观与更平和的情感状态,男性尤其如此,并且其情感幸福对公正观有微弱的正向预测（主要是积极情感）,但八个月后随着公正观与幸福感的回落,这种关联变得不显著。民众的情感幸福与公正观在常态下表现为分离的关系,但生活满意度这一幸福感的认知因素却与公正观一直有正向的关联。总之,情感幸福、认知幸福与社会认知的矛盾、变换关系,暗示了建立在私情基础之上的、在灾难中不断强化的中国人特定的情感与理性诉求。     

The Convergence of Cultures and Religions in Light of the Evolution of Conciousness

This article describes a challenge to the cultures and religions of the world that the author believes is the greatest challenge that has confronted the human race in its entire history. Modernity's search for unity and postmodernity's affirmation of pluralism reflect aspects of our current situation, but more needs to be recognized. We must acknowledge that East and West must face the current challenges together. Multiculturalism and unity encompass all world cultures, and we cannot be content to read our present history only through the lens of western developments. Karl Jaspers's theory of the First Axial period of history, 800-200 B.C.E ., in which all the present world religions have their roots, is useful. It reveals that our present flowering of culture and spirit in the Western world, including our science, is not so much a product of the Western Renaissance and Enlightenment, as it is rooted in cultural events that belong to East and West equally. We are now in the Second Axial Period, which challenges the world religions to allow their energies to move toward convergence, just as in the previous millennia they moved toward differentiation. Teilhard de Chardin's thought is a guide for us, in his vision of a complex convergence of consciousness, in which differences will not be abolished but will be transformed in their coming together. This convergent perspective will also join with the perspective of rediscovering our roots in the earth, and it will repossess the spirituality of the primal peoples, in its understanding of the entire human race to be one tribe. The world religions are faced with the task, therefore, of encountering each other in "dialogic dialogue," and channeling their spiritual resources toward the solution of real-world global problems.     

Some small sample results for maximum likelihood estimation in multidimensional scaling

Some aspects of the small sample behavior of maximum likelihood estimates in multidimensional scaling are investigated by Monte Carlo. An investigation of Model M2 in the MULTISCALE program package shows that the chi-square test of dimensionality requires a correction of tabled chi-square values to be unbiased. A formula for this correction in the case of two dimensions is estimated. The power of the test of dimensionality is acceptable with as few as two replications for 15 stimuli and as few as five replications for 10 stimuli. The biases in the exponent and standard error estimates in this model are also investigated.The research reported here was supported by grant number APA 320 to the author by the National Science and Engineering Research Council of Canada.     

Word meaning and the control of eye fixation: semantic competitor effects and the visual world paradigm

When participants are presented simultaneously with spoken language and a visual display depicting objects to which that language refers, participants spontaneously fixate the visual referents of the words being heard [Cooper, R. M. (1974). The control of eye fixation by the meaning of spoken language: A new methodology for the real-time investigation of speech perception, memory, and language processing. Cognitive Psychology, 6(1), 84-107; Tanenhaus, M. K., Spivey-Knowlton, M. J., Eberhard, K. M., & Sedivy, J. C. (1995). Integration of visual and linguistic information in spoken language comprehension. Science, 268(5217), 1632-1634]. We demonstrate here that such spontaneous fixation can be driven by partial semantic overlap between a word and a visual object. Participants heard the word ‘piano’ when (a) a piano was depicted amongst unrelated distractors; (b) a trumpet was depicted amongst those same distractors; and (c), both the piano and trumpet were depicted. The probability of fixating the piano and the trumpet in the first two conditions rose as the word ‘piano’ unfolded. In the final condition, only fixations to the piano rose, although the trumpet was fixated more than the distractors. We conclude that eye movements are driven by the degree of match, along various dimensions that go beyond simple visual form, between a word and the mental representations of objects in the concurrent visual field.     

The Reception of Dewey in the Hispanic World

The aim of this paper is to describe Dewey’s reception in the Spanish-speaking countries that constitute the Hispanic world. Without any doubt, it can be said that in the past century Spain and the countries of South America have been a world apart, lagging far behind the mainstream Western world. It includes a number of names and facts about the early translation of Dewey’s works in Spain, Chile, Cuba, Mexico and Argentina in the first half of the century and a brief explanation of the decline of Dewey in the second half. To a great extent, Dewey’s conception of education was immersed in the international movement of reform that started at the turn of the century and would eventually slowly but surely, renovate the structure of the educational system throughout the entire century, including that of South America. But it is equally clear that the Spanish-speaking countries have displayed a general ignorance of Dewey and, by extension, of American pragmatism during most of the century. In spite of mutual incomprehension, a deep affinity between Dewey’s pragmatism and Hispanic philosophy is suggested in this paper, anticipating that the gradual process of democratization of Spain and the Hispanic countries of South America may be in some sense related to the rediscovery of Dewey and to the application of his key ideas in education. After decades of neglect of Dewey and of his contribution, there is a strong feeling not only that his conception of things is important to understand the last century but that Dewey – along with Peirce and other American classical pragmatists – may very well prove to be a key thinker for the XXIst century also in the Hispanic world. Along this vein, the recent resurgence of pragmatism can be understood not as the latest academic fashion but the occasion to start to close the gap between the two worlds.     

The belief in a just world and distress at school

This article investigates the relationship between the belief in a just world (BJW) and distress at school. On the basis of just world theory, the authors argue that strong student BJW should be associated with low school distress. Two questionnaire studies with German secondary school students attending grades 7–13 are reported. Both studies found strong BJW to be associated with less distress at school, better grades, and the evaluation of grades and teachers as more just. Moreover, the relationship between strong BJW and low school distress persisted when controlled for grades, justice of grades, and teacher justice. This relationship held for all students, independently of their school track, grade level, or gender. Overall, the pattern of results reveals school distress to have a unique association with BJW and school-specific justice cognitions.