肿瘤治疗模式的哲学思考

外科手术往往是肿瘤治疗的首选方法,对于不能手术或已丧失手术机会者才考虑放疗,化疗。近年来,出现了诱导分化和凋亡等治疗手段,且在某些肿瘤的治疗上已取得了可喜的效果,这点新概念,新手术的出现,使得以往的肿瘤治疗模式受到了冲击,从以人为本,预防为主的哲学思想出发,我们似科可以提出这样的肿瘤治疗模式,诱导分化→启动凋亡→手术,放疗,化疗。     

Some small sample results for maximum likelihood estimation in multidimensional scaling

Some aspects of the small sample behavior of maximum likelihood estimates in multidimensional scaling are investigated by Monte Carlo. An investigation of Model M2 in the MULTISCALE program package shows that the chi-square test of dimensionality requires a correction of tabled chi-square values to be unbiased. A formula for this correction in the case of two dimensions is estimated. The power of the test of dimensionality is acceptable with as few as two replications for 15 stimuli and as few as five replications for 10 stimuli. The biases in the exponent and standard error estimates in this model are also investigated.The research reported here was supported by grant number APA 320 to the author by the National Science and Engineering Research Council of Canada.     

小剂量酒精伤害驾驶行为的时序效应

酒后开车普遍存在并致交通肇事居高不下的现实,对法定酒精限量的科学性提出质疑.本实验在多数国家交通法规采用的体内血液酒精水平BAL＜0.5‰的标准以下,设计三项任务对12名被试在酒前酒后四段时间内的行为实施测试,结果表明个体无法准确估计安全的酒精摄入量;小剂量酒精仍具有伤害行为的效应;酒精影响依行为复杂程度呈现时序效应.     

What Causes the Mean Bias of the Likelihood Ratio Statistic with Many Variables?

Abstract

Survey data often contain many variables. Structural equation modeling (SEM) is commonly used in analyzing such data. However, conventional SEM methods are not crafted to handle data with a large number of variables (p). A large p can cause T_ml, the most widely used likelihood ratio statistic, to depart drastically from the assumed chi-square distribution even with normally distributed data and a relatively large sample size N. A key element affecting this behavior of T_ml is its mean bias. The focus of this article is to determine the cause of the bias. To this end, empirical means of T_ml via Monte Carlo simulation are used to obtain the empirical bias. The most effective predictors of the mean bias are subsequently identified and their predictive utility examined. The results are further used to predict type I errors of T_ml. The article also illustrates how to use the obtained results to determine the required sample size for T_ml to behave reasonably well. A real data example is presented to show the effect of the mean bias on model inference as well as how to correct the bias in practice.     

基于人类注意机制的微表情检测方法

微表情是一种持续时间极短、不易被察觉的面部动作, 揭示了个体的真实情绪, 可以被广泛地应用于谎言识别等领域。而微表情检测的研究受到小样本问题的限制。针对该问题, 本文结合计算机视觉技术与认知心理学实验方法进行探索。首先, 结合眼动技术和呈现-判断范式与阈下情绪启动效应的行为实验范式, 考察微表情识别中选择注意分配的认知机制, 细化人类识别微表情时的特征兴趣区域。其次, 结合人类注意机制, 提出基于自监督学习的多模态微表情检测方法。通过理论和关键技术的突破, 为真实场景下微表情检测的应用奠定基础。     

微流控芯片技术与肿瘤微环境

微流控芯片或芯片实验室或微型全分析系统是在微机械、微电子、生物工程和纳米技术的基础上发展起来的.与传统的实验技术相比,微流控芯片技术以其微型化、集成化、自动化、快速分析、低消耗等优点,不仅在分析化学,物理和化学工程等领域中有出色的应用,近年来在生物工程和再生医学等方面的应用也崭露头角,尤其是微流控技术在肿瘤发生发展的时空微环境研究中发挥出巨大优势.本文就微流控芯片技术在肿瘤微环境中的研究优势进行阐述.     

Impact of negative cognitions about body image on inflammatory status in relation to health

Objective: Evidence suggests that body dissatisfaction may relate to biological processes and that negative cognitions can influence physical health through the complex pathways linking psychological and biological factors.

Design: The present study investigates the relationships between body image satisfaction, inflammation (cytokine levels), aerobic fitness level and obesity in 96 middle-aged men and women (48 normal and 48 overweight). All participants underwent measurements of body satisfaction, body composition, serological measurements of inflammation and aerobic capabilities assessment.

Results: Body image dissatisfaction uniquely predicted inflammation biomarkers, C-reactive protein and tumour necrosis factor-α, even when controlled for obesity indicators. Thus, body image dissatisfaction is strongly linked to inflammation processes and may promote the increase in cytokines, representing a relative metabolic risk, independent of most traditional risk factors, such as gender, body mass index and intra-abdominal (waist to hip ratio) adiposity.

Conclusion: Results highlight the fact that person’s negative cognitions need to be considered in psychologically based interventions and strategies in treatment of obesity, including strategies for health promotion. Results contribute to the knowledge base of the complex pathways in the association between psychological factors and physical illness and some important attempts were made to explain the psychological pathways linking cognitions with inflammation.     

The Dopamine D4 Receptor (DRD4) Exon 3 VNTR Contributes to Adaptive Personality Differences in an Italian Small Island Population

The search for evolutionary forces shaping the diversity of human personality traits encouraged studies that have found that islanders are relatively closed and introverted, with little interest in the external world. The ‘personality gene flow’ hypothesis was proposed to explain the mechanism underlying this difference, suggesting that the frequency of alleles that influence islander personality traits might progressively increase in the gene pools on islands because of selective emigration of individuals not displaying these alleles. We genotyped 96 individuals from the Italian mainland and 117 from Giglio Island, whose residents were previously assessed regarding their personality traits. We genotyped three polymorphisms: the dopamine D4 receptor (DRD4) exon 3 repeat region, the serotonin‐transporter SLC6A4 5‐HTTLPR indel and the dopamine transporter SLC6A3 DAT1 3′UTR repeat region. Only the DRD4 exon 3 repeat was hypothesised to show varying allele frequencies because this polymorphism could be associated with human migration and personality traits such as extraversion, openness and novelty seeking. As predicted, no differences in allele frequencies were found for the SLC6A4 and SLC6A3 polymorphisms, whereas significant differences were observed in the frequency of the DRD4 exon 3 alleles. The DRD4.2 repeat was more common in mainlanders, as expected, whereas the DRD4.7 allele was over‐represented among islanders who never emigrated. This last result contradicts the suggested association of this allele with long‐distance migrations. We suggest that emigration might have caused gene flow out the island that resulted in somewhat unpredictable changes in the frequencies of specific alleles, thus influencing islander personality traits. Copyright © 2013 European Association of Personality Psychology     

Parent Report of Attention Problems Predicts Later Adaptive Functioning in Children with Brain Tumors

Children with brain tumors are at risk for psychological and behavioral difficulties. This study examined the ability of parent report of attention problems, withdrawal, anxiety, and depression, as well as IQ, to predict later adaptive functioning in 42 children treated for brain tumors. Age at diagnosis, SES, gender, and scores on the Neurological Predictor Scale (NPS) also were examined as predictors. Parent report of attention problems, SES, and NPS were significant predictors of later adaptive functioning across domains. This finding highlights the ability of parent report of attention problems to predict later adaptive functioning in children treated for brain tumors.     

肿瘤数据库及组织库的建设

随着肿瘤研究的日益深入,肿瘤组织库的重要性逐渐显现,世界各地都建立了肿瘤组织库。作为肿瘤组织库管理系统和肿瘤临床资料收集、管理者的肿瘤数据库在组织库建设以及肿瘤研究中具有重要的作用。近十年来,我国的肿瘤数据库和组织库开始出现,仍处于起步阶段,存在着诸多问题,建立标准化数据库和组织库具有十分重要的意义。