A Novel Approach to Enhancing Upper Extremity Coordination in Children with Autism Spectrum Disorder

Abstract

Recent studies examining children diagnosed with Autism Spectrum Disorder (ASD) have revealed kinematic markers highlighting deficits in the preparatory and online phases of upper extremity movements. In the following study, 12 children with high functioning ASD were first assessed (pre-test) on 15 trials of a reciprocal upper extremity Fitts Law target task by flexing and extending their right arm in the horizontal plane between two targets as fast and accurately as possible. Following the initial assessment, the children either continued with 30 additional trials of the target task (control) or were asked to track a sine wave template (experimental). All participants were then assessed on 15 trials of the target test (post-test). Results reveal that tracking the sine wave template during training not only produced faster movements compared to the control but also produced these movements in a more harmonic way.     

快速与慢速读者的中央凹加工对副中央凹预视的影响

在中文阅读中, 预视量是否存在个体差异及其是否受中央凹加工调节, 尚不清楚。本研究采用眼动技术和边界范式, 通过操纵前目标词的加工负荷(高、低)与目标词的预视(相同、假字)来考察快速与慢速读者的中央凹加工对副中央凹预视的影响。结果显示, 中央凹负荷主效应显著; 快速读者对低负荷词的首次和单次注视短于高负荷词, 而慢速读者对两种负荷词的首次和单次注视无差异, 表明快速读者能更快利用词汇特性加工中央凹词汇。预视主效应显著, 即与假字预视相比, 相同预视使两组读者都对目标词的注视更短、向前眼跳更长、跳读率更高; 而且该效应与中央凹负荷没有交互作用。这表明快速读者与慢速读者提取了等量预视, 且不受其中央凹加工的调节。E-Z读者模型和SWIFT模型不能完全解释当前结果。     

Elderhood: Aging's new frontier

Drawing on folk wisdom and the social sciences, the surge in older adulthood is re‐framed as a new frontier of individual and societal opportunity.     

Transverse shear surface wave in a functionally graded material infinite half space

The variable substitution and power-series techniques are used for the asymptotic analytical derivation of the governing equation of a transverse surface wave. The results reveal that the transverse wave can propagate along the surface of a functionally graded infinite half space in various modes, and that their dispersion relations are normal. For certain cases, energy is concentrated on the surface region to a depth of several wavelengths. A new theoretical foundation based on the transverse surface wave can be provided for graded-material characterization by experimental measurement. Some phenomena of seismic wave propagation may also be explained.     

J波、fQRS、Tp-ec对ST段抬高性心肌梗死溶栓治疗后恶性心律失常的预测价值

探讨ST段抬高性心肌梗死(STEMI)患者成功溶栓治疗后J波、校正Tp-e间期(Tp-ec)、碎裂QRS波(fQRS)对恶性心律失常事件(MAE)的预测价值及其相关性.选择STEMI患者108例,成功溶栓治疗后随机分为MAE组(29例)和非MAE(NMAE)组(79例),72例正常人的心电图作为对照组.结果示MAE组J波阳性、fQRS阳性、Tp-ec≥100ms显著高于NMAE组(P＜0.05);STEMI患者Tp-ec较对照组显著延长(P＜0.05),经溶栓治疗后,Tp-ec1周和1个月时逐渐恢复,但Tp-ec仍较对照组显著延长(P＜0.05);J波阳性(OR=3.612)、fQRS阳性(OR=2.905)、Tp-ec≥100ms(OR=3.226)(均P＜0.05)与MAE的发生独立相关.以此认为J波、Tp-ec、fQRS和MAE正相关,对溶栓后MAE有预测作用.     

Neurophysiological indices of free recall memory biases in major depression: The impact of stimulus arousal and valence

This study examined differential impact of the valence and arousal characteristics of stimuli on memory biases and brain activity in major depressive disorder (MDD) and non-depressed control participants. P300 and slow wave (SW) components of the event-related brain potential (ERP) were recorded in 18 MDD and 18 control individuals during the encoding of positive and negative, high and low arousal words in a free recall task. Control participants demonstrated expected enhanced memory for positive stimuli that was accompanied by a corresponding increase in SW ERP components. These effects were not seen in the MDD participants. Rather, memory biases for negative information in MDD were only observed for low arousal words and were not reflected in ERP amplitudes. This study suggests that the inconsistency in the MDD memory bias literature may be related to the arousing nature of the stimuli incorporated in the study.     

A RESPONSE TO CARL HELRICH: THE LIMITATIONS AND PROMISE OF QUANTUM THEORY

Abstract. I respond to Carl Helrich's criticism of my proposition that the emergence of complex order in the universe is from Virtual State Actualization (VSA). The question is discussed as to whether quantum theory is able to afford any kind of quantum ontology or whether it merely allows an epistemological view. I point out that, even though many contradictory interpretations of quantum theory are currently possible, the concept of VSA is based on molecular properties that are so simple and factual that they are beyond interpretation. Helrich's appeal for caution in proceeding from physical reality to Divine Reality is wholeheartedly supported and a detailed discussion is given.     

Positive relationship between passive muscle stiffness and rapid force production

We aimed to examine the relationship among the muscle shear modulus at rest, maximal joint torque, and rate of torque development (RTD). Twenty-seven participants (28 ± 5 years, 13 women) were recruited in the study. The cross-sectional area (CSA) of the medial gastrocnemius (MG) muscle belly and shear modulus at an ankle joint angle of 0° were calculated using magnetic resonance imaging and ultrasound shear wave elastography, respectively. Subsequently, participants performed maximal isometric plantar flexion at 0° ankle joint angle [maximal voluntary contraction (MVC) test] as fast and hard as possible (RTD test). RTD was calculated from the time–torque curve over time intervals of 0–30, 0–50, 0–100, 0–150, and 0–200 ms from the onset of plantar flexion during the RTD test and was normalized by MVC torque to exclude muscle strength. MG CSA correlated significantly with MVC torque (r = 0.572), whereas MG shear modulus did not. In contrast, MG shear modulus correlated significantly with normalized RTD at all time intervals (r = 0.460–0.496). These results suggest that passive muscle stiffness is not associated with muscle force; however, higher passive muscle stiffness at a given joint angle may contribute to rapid force production.     

Disentangling fast and slow attentional influences of negative and taboo spoken words in the emotional Stroop paradigm

Although the influence of the emotional content of stimuli on attention has been considered as occurring within trial, recent studies revealed that the presentation of such stimuli would also involve a slow component. The aim of the present study was to investigate fast and slow effects of negative (Exp. 1) and taboo (Exp. 2) spoken words. For this purpose, we used an auditory variant of the emotional Stroop paradigm in which each emotional word was followed by a sequence of neutral words. Replicating results from our previous study, we observed slow but no fast effects of negative and taboo words, which we interpreted as reflecting difficulties to disengage attention from their emotional dimension. Interestingly, while the presentation of a negative word only delayed the processing of the immediately subsequent neutral word, slow effects of taboo words were long-lasting. Nevertheless, such attentional effects were only observed when the emotional words were presented in the first block of trials, suggesting that once participants develop strategies to perform the task, attention-grabbing effects of emotional words disappear. Hence, far from being automatic, the occurrence of these effects would depend on participants' attentional set.     

心算对内外倾者的心率、T波幅度和呼吸频率的影响

该文旨在探讨内、外倾者在三种不同难度心算时,心率、Ｔ波幅度、呼吸频率变化的差异。通过艾森克个性问卷筛选出１５名内倾者和１５名外倾者作为被试,让其完成三种不同难度的心算任务。实验结果表明,心算时两组被试心率均显著上升,内倾组上升幅度大于外倾组;Ｔ波幅度显著降低,内倾组降低幅度大于外倾组但差异不显著;呼吸频率显著上升,但两组上升幅度差异不显著。此外,从心率变化上看,两组被试对心算均表现出适应,内倾组的适应速度比外倾组慢。本实验表明,焦虑性精神紧张比智力操作性精神紧张对心率的影响更大。