Does performance on the standard antisaccade task meet the co-familiality criterion for an endophenotype?

The “co-familiality” criterion for an endophenotype has two requirements: (1) clinically unaffected relatives as a group should show both a shift in mean performance and an increase in variance compared with controls; (2) performance scores should be heritable. Performance on the antisaccade task is one of several candidate endophenotypes for schizophrenia. In this paper we examine whether the various measures of performance on the standard version of the antisaccade task meet the co-familiality criterion for an endophenotype. The three measures of performance—reflexive saccade errors, latency of correct antisaccades, and gain—show a wide range of effect sizes and variance ratios as well as evidence of significant or near significant heterogeneity. The estimated mean effect sizes [Cohen’s d: error rate: 0.34 (SD: 0.29); latency: 0.33 (SD: 0.30); gain: 0.54 (SD: 0.38)] are significantly greater than 0, but the magnitude of the departures from 0 is relatively small, corresponding to modest effect sizes. The width of the 95% confidence intervals for the estimated effect sizes (error rate: 0.2–0.49; latency: 0.17–0.50; gain: 0.23–0.85) and the coefficients of variation in effect sizes (error rate: 85.3%; latency: 90.9%; gain: 68.4%) reflect heterogeneity in effect sizes. The effect sizes for error rate showed statistically significant heterogeneity and those for latency (P = .07) and gain (P = .09) showed a trend toward heterogeneity. These results indicate that the effect sizes are not consistent with a single mean and that the average effect size may be a biased estimate of the magnitude of differences in performance between relatives of schizophrenics and controls. Relatives of schizophrenics show a small but significant increase in variance in error rate, but the confidence interval is broad, perhaps reflecting the heterogeneity in effect size. The variance ratios for latency and gain did not differ in relatives of schizophrenics and controls. Performance, as measured by error rate, is moderately heritable. The data do not provide compelling support for a consistent shift in mean or variance in relatives of schizophrenia patients compared with nonpsychiatric controls, both of which are required for a major gene involved in co-familial transmission. This set of findings suggests that although intra-familial resemblance in antisaccade performance is due in part to genetic factors, it may not be related to a schizophrenia genotype. Based on the current literature, it would be premature to conclude that any of the measures of antisaccade performance unambiguously meets the co-familiality criterion for an endophenotype.     

Limited information estimation and testing of discretized multivariate normal structural models

Discretized multivariate normal structural models are often estimated using multistage estimation procedures. The asymptotic properties of parameter estimates, standard errors, and tests of structural restrictions on thresholds and polychoric correlations are well known. It was not clear how to assess the overall discrepancy between the contingency table and the model for these estimators. It is shown that the overall discrepancy can be decomposed into a distributional discrepancy and a structural discrepancy. A test of the overall model specification is proposed, as well as a test of the distributional specification (i.e., discretized multivariate normality). Also, the small sample performance of overall, distributional, and structural tests, as well as of parameter estimates and standard errors is investigated under conditions of correct model specification and also under mild structural and/or distributional misspecification. It is found that relatively small samples are needed for parameter estimates, standard errors, and structural tests. Larger samples are needed for the distributional and overall tests. Furthermore, parameter estimates, standard errors, and structural tests are surprisingly robust to distributional misspecification. This research was supported by the Department of Universities, Research and Information Society (DURSI) of the Catalan Government, and by grants BSO2000-0661 and BSO2003-08507 of the Spanish Ministry of Science and Technology.     

Keeping an eye on the truth? Pupil size changes associated with recognition memory

During recognition memory tests participants' pupils dilate more when they view old items compared to novel items. We sought to replicate this “pupil old/new effect” and to determine its relationship to participants' responses. We compared changes in pupil size during recognition when participants were given standard recognition memory instructions, instructions to feign amnesia, and instructions to report all items as new. Participants' pupils dilated more to old items compared to new items under all three instruction conditions. This finding suggests that the increase in pupil size that occurs when participants encounter previously studied items is not under conscious control. Given that pupil size can be reliably and simply measured, the pupil old/new effect may have potential in clinical settings as a means for determining whether patients are feigning memory loss.     

It's in the sample: the effects of sample size and sample diversity on the breadth of inductive generalization

Developmental studies have provided mixed evidence with regard to the question of whether children consider sample size and sample diversity in their inductive generalizations. Results from four experiments with 105 undergraduates, 105 school-age children (M = 7.2 years), and 105 preschoolers (M = 4.9 years) showed that preschoolers made a higher rate of projections from large samples than from small samples when samples were diverse (Experiments 1 and 3) but not when samples were homogeneous (Experiment 4) and not when the task required a choice between two samples (Experiment 2). Furthermore, when a property occurred in large and diverse samples, preschoolers exhibited a broad pattern of projection, generalizing the property to items from categories not represented in the evidence. In contrast, adults followed a normative pattern of induction and never attributed properties to items from categories not represented in the evidence. School-age children showed a mixed pattern of results.     

Effects of the global and local attention on the processing of categorical and coordinate spatial relations

Participants made categorical or coordinate spatial judgments on the global or local elements of shapes. Stimuli were composed of a horizontal line and two dots. In the Categorical task, participants judged whether the line was above or below the dots. In the Coordinate task, they judged whether the line would fit between the dots. Stimuli were made hierarchical so that the global patterns composed of a “global line” made of local dots-and-line units, and “global dot” made of a single dots-and-line unit. The results indicated that the categorical task was better performed when participants attended to the local level of the hierarchical stimuli. On the other hand, the coordinate task was better performed when they attended to the global level. These findings are consistent with computer simulation models of the attentional modulation of neuronal receptive fields’ size suggesting that (1) coordinate spatial relations are more efficiently encoded when one attends to a relatively large region of space, whereas (2) categorical spatial relations are more efficiently encoded when one attends to a relatively small region of space.     

Test theory without an answer key

A general model is presented for homogeneous, dichotomous items when the answer key is not known a priori. The model is structurally related to the two-class latent structure model with the roles of respondents and items interchanged. For very small sets of respondents, iterative maximum likelihood estimates of the parameters can be obtained by existing methods. For other situations, new estimation methods are developed and assessed with Monte Carlo data. The answer key can be accurately reconstructed with relatively small sets of respondents. The model is useful when a researcher wants to study objectively the knowledge possessed by members of a culturally coherent group that the researcher is not a member of.This research was supported by NSF Grant No. SES-8320173 to the authors. We gratefully acknowledge comments and suggestions from John Boyd, Tarow Indow, and Kathy Maher as well as the editor and several anonymous referees.     

A cost-benefit analysis of demand for food.

Laboratory studies of consumer demand theory require assumptions regarding the definition of price in the absence of a medium of exchange (money). In this study we test the proposition that the fundamental dimension of price is a cost-benefit ratio expressed as the effort expended per unit of food value consumed. Using rats as subjects, we tested the generality of this "unit price" concept by varying four dimensions of price: fixed-ratio schedule, number of food pellets per fixed-ratio completion, probability of reinforcement, and response lever weight or effort. Two levels of the last three factors were combined in a 2 x 2 x 2 design giving eight groups. Each group was studied under a series of six FR schedules. Using the nominal values of all factors to determine unit price, we found that grams of food consumed plotted as a function of unit price followed a single demand curve. Similarly, total work output (responses x effort) conformed to a single function when plotted in terms of unit price. These observations provided a template for interpreting the effects of biological factors, such as brain lesions or drugs, that might alter the cost-benefit ratio.     

低色温低强度背景光照射下液晶显示颜色编码的实验研究

采用一台有源矩阵彩色液晶显示器作为主要实验装置,对低色温、低强度背景光照射下液晶显示颜色编码范围及其与色标大小的关系进行了研究。实验结果表明:(1)液晶显示器上色标大小对绝对辨认效果有显著影响,随着色标的增大,辨认错误率随之下降,但下降率则随色标的增大而递减。(2)在色温为3100K的低强度背景光照射下,液晶显示的颜色编码范围因色标大小不同而存在显著差异,当色标面积减小到1×1mm2至2×2mm2时,编码色数目仅限于3-4种。     

Upward versus Downward Anchoring in Frequency Judgments of Social Facts

Frequency estimation of social facts in two methods of judgment elicitation was investigated. In the “narrow-range” condition, subjects answered questions in the format: “Out of 100 incidents, how many belong to category X?” In the “wide-range” condition, the frequency for the same event was assessed with respect to “Out of 10,000”. Judged frequencies in the wide-range condition were divided by 100, and were compared with the corresponding judgments in the narrow-range condition. Such comparisons were made for low-frequency and high-frequency events. Previous research has shown that, for low-frequency events, judged frequencies are proportionally greater in the narrow-range than in the wide-range condition. These results reflect cognitive processes of implicit anchoring, whereby judged frequencies lie close to small numbers within the response ranges provided. I call this process “downward anchoring,” and predicted that this tendency would be replicated in the present study. Moreover, I predicted that assessments about high-frequency events would evoke similar cognitive processes operating in the opposite direction. By such “upward anchoring,” judged frequencies would lie close to relatively larger numbers within the given response ranges. Consequently, I predicted that judged frequencies for high-frequency events would be proportionally greater in the wide-range condition than in the narrow-range condition. These predictions were confirmed.