肠促胰素对2型糖尿病胰岛功能的影响

胰岛β细胞功能障碍是2型糖尿病的重要发病机制之一,而现有治疗手段保护β细胞功能作用有限。最新的研究发现,肠促胰素不仅能够改善口细胞功能,而且能够避免低血糖、体重增加等不良反应,是治疗2型糖尿病的新途径。本文通过回顾公开发表的临床研究,对2型糖尿病口细胞功能、传统治疗及肠促胰素对β细胞功能的保护及延缓疾病进展作用进行了综...     

糖尿病与睡眠的相互关系

人一生中有1／3的时间在睡眠中度过,睡眠质量直接关系到一个人的身体健康。睡眠时间过少或过多的人糖尿病患病率大大增加。糖尿病本身的病理、生理特点,严重影响患者的睡眠质量,睡眠质量又可以反过来影响糖尿病患者的血糖水平。有研究显示,糖尿病患者最佳睡眠时间为8小时。同时糖尿病患者中睡眠呼吸暂停综合征（OSAS）患病率高,0SA...     

Seeing the future: Natural image sequences produce “anticipatory” neuronal activity and bias perceptual report

This paper relates human perception to the functioning of cells in the temporal cortex that are engaged in high-level pattern processing. We review historical developments concerning (a) the functional organization of cells processing faces and (b) the selectivity for faces in cell responses. We then focus on (c) the comparison of perception and cell responses to images of faces presented in sequences of unrelated images. Specifically the paper concerns the cell function and perception in circumstances where meaningful patterns occur momentarily in the context of a naturally or unnaturally changing visual environment. Experience of visual sequences allows anticipation, yet one sensory stimulus also “masks” perception and neural processing of subsequent stimuli. To understand this paradox we compared cell responses in monkey temporal cortex to body images presented individually, in pairs and in action sequences. Responses to one image suppressed responses to similar images for ～500 ms. This suppression led to responses peaking 100 ms earlier to image sequences than to isolated images (e.g., during head rotation, face-selective activity peaks before the face confronts the observer). Thus forward masking has unrecognized benefits for perception because it can transform neuronal activity to make it predictive during natural change.     

Preembryo Personhood: An Assessment of the President’s Council Arguments

The President’s Council on Bioethics has addressed the moral status of human preembryos in its reports on stem cell research and human therapeutic cloning. Although the Council has been criticized for being hand-picked to favor the right-to-life viewpoint concerning human preembryos, it has embraced the idea that the right-to-life position should be defended in secular terms. This is an important feature of the Council’s work, and it demonstrates a recognition of the need for genuine engagement between opposing sides in the debate over stem cell research. To promote this engagement, the Council has stated in secular terms several arguments for the personhood of human preembryos. This essay presents and critiques those arguments, and it concludes that they are unsuccessful. If the best arguments in support of the personhood of human preembryos have been presented by the Council, then there are no reasonable secular arguments in support of that view.     

免疫性疾病治疗新途径：诱导细胞程序性死亡

免疫性疾病是一大类难治性的免疫紊乱而造成的疾病,尤其是自身免疫性疾病的一直困扰着免疫学家。传统的免疫治疗是根据不同疾病的需要增强免疫,调节免疫和抑制的方式进行,以辩证的观点分析免疫的增殖与程序性死亡这一对矛盾,认为：免疫性疾病的本质是免疫细胞增殖与程序性恨的失衡,因而通过诱导免疫细胞程序性死亡将成为免疫治疗的新途径。     

Situation Taxonomy and Behavioral Diagnosis Using Prospective Self-Monitoring Data: Application to Dietary Adherence in Patients with Type 1 Diabetes

The goals of this study were to create a taxonomy of problem situations for diet adherence in persons with insulin-dependent diabetes mellitus (Type 1 diabetes) and a behavioral diagnosis by grouping patients together who have similar adherence problems. In study one, 29 patients with Type 1 diabetes kept food diaries for 4 weeks. Adherence was assessed using eight behavioral measures: (1) compliance with a meal plan, (2) energy intake, (3) protein, (4) carbohydrates, (5) fat, (6) self-reported overeating, (7) self-reported undereating, and (8) ratings of impulsive eating. The occurrence of each behavior was quantified in a wide range of situational contexts including meal, social context, physical location, and mood. Cluster analysis of behaviors, situations, and behaviors-in-situations was used to create a hierarchical classification model consisting of five major categories of adherence problems: (1) compliance with meal plan, (2) undereating, (3) overeating, (4) impulsive eating, and (5) lifestyle differences. Within each category, situations were associated with everyday eating habits and special circumstances such as social events, and meals in restaurants. Grouping patients based on the similarity of their adherence problems resulted in five diagnostic groups: (1) emotional binge eaters, (2) restrained eaters, (3) unrestrained eaters, (4) undereaters, and (5) cyclical diet bingers. In study two, 28 subjects kept diaries during an intervention program designed to enhance dietary adherence. Study two results were similar to study one. Situation taxonomy and behavioral diagnosis are potentially useful ways to understand the intervention needs of those attempting maintaining dietary behavior changes.     

人是怎样与世界统一的——一个关于细胞信息跨膜传递特异性的假说

本文在讨论有限和无限的对立统一规律在抗原和抗体产生机制中的体现的基础上,提出关于细胞信息跨膜传递特异性机制的假说：第一信使可能由有限的基本单位构成,其信息的特异性可能通过有限的信息中介的组合来得以体现,效应部位也可能因具有特定的信息中介结合位点的组合而产生特异的细胞效应。本文最后为这一假说的证实提出展望。     

Predictors of Psychosocial and Cognitive Adaptation in Children with Sickle Cell Syndromes

Examined the role of socioecological factors (family functioning and socioeconomic variables) in predicting behavioral and cognitive adaptation in children with sickle cell syndromes (SCD). Participants included 74 African American children and adolescents with SCD and their primary caretakers. Outcomes included internalizing and externalizing behavior symptoms, as rated by caretakers, as well as intellectual abilities and academic achievement, as assessed by individually administered standardized instruments. Family functioning consisted of both caretaker adjustment and family environment (i.e., family adaptability and cohesion). Hierarchical multiple regression analyses revealed that caretaker psychological adjustment predicted externalizing behaviors, while family environment (i.e., adaptability and cohesion) predicted neither behavioral nor cognitive functioning. Socioeconomic variables alone predicted intellectual abilities and academic achievement and also contributed to the prediction of child behavioral adaptation. Results are discussed in terms of relevant sociocultural issues and implications for family-level prevention and intervention.     

Family management of childhood diabetes

This paper reviews the available literature on family management of childhood diabetes and highlights gaps in the current knowledge base. Four aspects of family management of childhood diabetes are discussed: coping (how the family adjusts to living with a child who has diabetes), compliance (how the family manages the child's diabetes on a daily basis), communication (how the family learns from interactions with the health provider), and context (how the family environment sets the stage for managing diabetes).     

Spouses' responses to the dietary nonadherence of their partners managing diabetes

The association between patients' dietary nonadherence and spouses' involvement in patients' diabetes diet was examined, with spouses' anxiety about nonadherence considered as a mediator of this association. Daily diary data from 128 older adult patients with type 2 diabetes and their spouses were analyzed using multilevel models. Results revealed that on days when patients reported less adherence to their diabetes diet than usual, spouses reported greater anxiety about patients' diabetes management, which, in turn, was related to greater spousal persuasion and pressure the same day. The association between patients' nonadherence and diet‐related support on the same day was not mediated, however, through spouses' anxiety. The findings contribute to an understanding of spouses' responses to patients' nonadherence to their diabetes regimen.