Dissimilarity in mother and adolescent illness representations of type 1 diabetes and negative emotional adjustment

The study explored how two measures of mother–adolescent dissimilarity in illness representations relate to negative emotional adjustment in mothers and adolescents. Eighty-four adolescents with type 1 diabetes (age 11.5–17.5) and their mothers completed the Revised Illness Perceptions Questionnaire and measures of negative emotional adjustment. Adolescents viewed diabetes as less chronic, containing fewer negative emotional representations, and that mother had less control over the illness than did mothers. Mother–adolescent mean differences in representations were not associated with negative adjustment for adolescents; mean differences in coherence were related to negative adjustment for mothers, when controlling the individual's own representations. A measure of dissimilarity based on the sum of squared differences between mother and adolescent was associated with negative adolescent adjustment when controlling adolescent's own representations, but no relations were found for mothers. Dyadic approaches to coping with chronic illness will benefit by understanding how dissimilarity in illness representations between patient and caregiver relate to adjustment.     

Inhibitory Control in Children with Frontal Infarcts Related to Sickle Cell Disease

Evidence from past studies indicates that children with traumatic brain injury experience difficulties with inhibitory control. Less is known about inhibitory control in children with frontal brain injury related to cerebral infarction. We compared the inhibitory performance of children with frontal infarcts related to sickle cell disease with that of a control group of children with sickle cell disease but no history of cerebral infarction. On a stimulus-response reversal task, children with frontal infarcts made significantly more accuracy errors in the inhibitory condition than controls. Findings from this study and from previous research suggest that impairments in inhibitory control are common following frontal injury in a range of pediatric populations.     

Association between biological markers of sickle cell disease and cognitive functioning amongst Cameroonian children

Background: Some of the major complications of sickle cell disease (SCD) occur in the brain and apart from overt stroke, patients also present with cognitive impairments. We sought to evaluate the prevalence of cognitive deficits as well as their biological predicting factors in young SCD patients in Cameroon.

Methods: The cognitive performances of Cameroonian SCD young patients were evaluated using a neuropsychological test battery assessing four domains of cognitive functioning (executive functions, attention, memory, and sensory-motor skills) previously adapted and normalized on healthy subjects in Yaoundé.

Findings: Up to 37.5% of the 96 SCD patients aged 6 to 24 years (M?=?13.5, SD?=?4.9) had mild-to-severe cognitive deficits. The cognitive deficits tend to increase with age. There was a significant effect of SCD on executive functions and attention, whereas SCD patients performed as well as controls on memory and sensory-motor skills tests. Structural equation models showed a significant association between (a) severe anemia and lower executive functioning, (b) low fetal hemoglobin levels and lower executive functioning and attention, (c) history of cerebrovascular accidents and lower performances in executive functioning, sensory-motor skills, and memory, (d) pathological electroencephalogram and lower attention, and (e) abnormal Transcranial Doppler and lower memory.

Conclusion: SCD patients in Cameroon presented a very high prevalence of cognitive deficits, with a specific impairment of executive functions and attention. Routine neuropsychological evaluation for early detection of cognitive deficits in SCD patients could represent a cost-effective tool to implement in resource-limited contexts such as in sub-Saharan Africa.     

Connection between deformation-induced dislocation substructures and martensite formation in stainless steel

We report a quantitative connection between the strain amplitude dependencies of the organisation of dislocation cell substructures with the formation of deformation-induced martensite during cyclic plasticity of austenitic stainless steel at ambient temperature.     

THE ABSTRACT SUBLIME: Life as information waiting to be rewritten

We report here on a series of interaction-intensive, interdisciplinary workshops to foster collaboration among those who teach, study, and engage with the public about scientific developments and social change—the New England Workshop on Science and Social Change. We include one line of thinking that fed into the workshops and present an analysis of how they contribute to participants developing their interest and skills in collaboration. Workshop evaluations suggest that people are moved to develop themselves as collaborators when they view an experience or training as transformative. Four R's—respect, risk, revelation, and re-engagement—point to the important conditions for interactions among researchers to be experienced as transformative. Three considerations lie behind the focus on the process side of the workshops, not the specific workshop topics: (1) how best to fill in for readers what they missed out on by not being there; (2) workshops and meetings are a ubiquitous part of the culture of science and technology studies (STS) so it is valuable to examine this aspect of our own culture with a view to promoting positive changes; and (3) in some scientific fields organized multi-person collaborative processes form a highly valorized aspect of the culture of science, so reflection on experiences of participation and collaboration in STS might inform our analyses of fields that emphasize collaboration and group processes. Indeed, the authors' own involvement in the workshops extends our own STS work on actor networks and ‘heterogeneous engineering’, that is, the mobilization of a variety of resources by diverse agents spanning different realms of social action.     

Salutary effect of daily coping self-efficacy: impact on day-by-day coping to mood effects within dyads following hematopoietic stem cell transplantation

ABSTRACT

Background and Objectives: Little is known how coping self-efficacy (CSE) interacts with coping in dyad everyday life. The present study examined the moderating role of daily CSE in the relationship between coping and the next-day positive (PA) or negative (NA) affect in patient-caregiver dyads, following hematopoietic stem cell transplantation.

Design: This intensive longitudinal study was conducted during the first 28 days after post-transplant discharge.

Methods: Patients and their caregivers (N?=?200) maintained daily diaries on CSE, coping strategies, and affect.

Results: Daily CSE moderated daily coping–affect relationship: Positive emotion-focused coping increased PA in patients with higher than usual emotion-related CSE, whereas a buffering effect was found at lower than usual emotion-related CSE. A positive association between negative emotion-focused coping and NA in both patients and caregivers was stronger among those with lower than usual levels of emotion-related CSE. Higher than usual instrumental coping reduced NA in patients whose caregivers had higher than usual problem-related CSE, but increased NA for those whose caregivers had lower than usual instrumental CSE.

Conclusion: The findings show that daily CSE contributes to the effectiveness of daily coping within dyad, confirming its significance in effective adaptation and the role in the dyadic coping process.     

Older age South African persons’ experiences of their needs with cell phone use

This study explored the needs met by cell phone use by older persons. Informants were 52 older South Africans (age range 65 to 89 years, male = 8, female = 44). The older persons completed a visual representation and semi-structured interviews on the needs met by their cell phone usage. Thematic analysis of the data revealed the following needs to be met by their cell phone usage: personal safety, sense of control, managing daily routine, and staying connected with loved ones. Findings are consistent with the propositions of the basic psychological needs theory (BPNT) regarding competence, autonomy, and personal well-being.     

亲代孕前成瘾药物暴露对子代行为的影响及其表观遗传机制

孕前成瘾药物暴露不仅危害使用者的身体健康,而且会对子代的生理行为造成影响,近年来研究发现表观遗传机制在其中发挥重要作用。孕前成瘾药物暴露会对子代的成瘾易感性和焦虑样行为造成影响,引起子代的抑郁样行为和认知受损。这些现象可能是成瘾药物通过引起亲代生殖细胞内表观遗传修饰变化所致,其中包括印记基因、神经递质系统、BDNF三个方面的表观遗传修饰变化。此外,未来除了加强以上三个方面基因的研究,也需要增加其他方面基因的研究,以及寻找能预测子代异常行为的表观遗传生物标志物。     

Association of social-environmental factors with cognitive function in children with sickle cell disease

The aim of this study was to examine the relationship between cognitive function in pediatric sickle cell disease (SCD) patients and mothers’ reports of social-environmental stress, depressive symptoms, and parenting. A total of 65 children with SCD completed comprehensive neuropsychological testing to assess several domains of cognitive functioning, including general intellectual ability, academic achievement, and executive function. Mothers reported on demographics, social-environmental stress, depressive symptoms, and parenting. As predicted, children with SCD significantly underperformed relative to normative data on measures of cognitive function. Associations between maternal social-environmental stress, maternal depressive symptoms, and parenting were mixed. The results show partial support for the hypothesis that greater stress and depressive symptoms and less positive parenting are associated with poorer cognitive function in children with SCD. Linear regression analyses showed that maternal financial stress was the strongest predictor across all domains of cognitive function. The findings replicate and extend past research, reaffirming that children with SCD are at risk for cognitive impairment across multiple domains. Additionally, social-environmental stress, particularly financial strain, is linked to mothers’ depressive symptoms and parenting behaviors as well as children’s cognitive function. Future studies using direct observations of parenting behaviors are needed. These findings, along with recent research on parenting interventions, may inform the development of concrete, teachable parenting and coping skills to improve cognitive functioning in children with SCD.     

若干实验室指标对糖尿病神经病变的预测意义

近年来,人们发现了一些实验室指标对糖尿病神经病变有一定预测意义,包括糖化血红蛋白、维生素B12、甲基丙二酸、全反钴胺素、同型半胱氨酸、氧化型低密度脂蛋白、甘油三酯、超敏C反应蛋白、肿瘤坏死因子α(TNF-α)、可溶性肿瘤坏死因子受体1、可溶性肿瘤坏死因子受体2等。这些指标对糖尿病神经病变的早期防治提供了帮助。