Does experienced pain affects local brain volumes? Insights from a clinical acute pain model

Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage.     

消费者自我构念、独特性需求与品牌标识形状偏好

市场上品牌标识形状各具形态,它们已成为吸引消费者眼球的重要品牌要素,如何设计出科学实效的品牌标识形状已成为营销策略中基础而又关键的内容。什么形状的品牌标识更能获得目标群体的偏爱?本文从自我构念的水平视角出发,推论认为不同自我构念的个体在"独特性需求"上具有显著差异,由此形成对多角和圆润的品牌标识形状的偏好差异,独特性需求在自我构念与品牌标识形状偏好之间起中介作用。文章通过4个实验,一致证实独立型自我构念的消费者独特性需求更高,偏爱多角的品牌标识;相依型自我构念的消费者,独特性需求更低,偏爱圆润的品牌标识。但上述效应只存在于公开产品购买情境,当消费者购买和使用私人产品时,无论个体的自我构念是独立型还是相依型,他们对品牌标识多角与圆润的偏好没有显著差异。本文推进了自我构念、独特性需求、品牌标识形状等领域的理论研究,为企业在设计、调整品牌标识形状及制定配套营销策略方面提供了丰富的战略启示。     

After-effects induced by interactions between hydrogen and the martensite transformation in Ni–Ti superelastic alloy

The effects of dynamic interactions between hydrogen and a stress-induced martensite transformation on the recovery of deteriorated tensile properties by ageing in air at room temperature have been investigated for a Ni–Ti superelastic alloy. A specimen is subjected to single stress-induced martensite and reverse transformations immediately after hydrogen charging. Upon tensile testing, brittle fracture occurs in the latter half of the elastic deformation region of the martensite phase after the stress-induced martensite transformation. Upon ageing before the tensile test, fracture occurs during the stress-induced martensite transformation. In addition, the nano- and micro-morphologies of the brittle outer part of the fracture surface of the specimen are changed by ageing. Thus, the tensile properties markedly deteriorate, rather than recover, by ageing. The present results clearly indicate that dynamic interactions between hydrogen and the stress-induced martensite transformation have serious after-effects on hydrogen embrittlement of Ni–Ti superelastic alloy.     

Atypical shape bias and categorization in autism: Evidence from children and computational simulations

The shape bias, a preference for mapping new word labels onto the shape rather than the color or texture of referents, has been postulated as a word‐learning mechanism. Previous research has shown deficits in the shape bias in children with autism even though they acquire sizeable lexicons. While previous explanations have suggested the atypical use of color for label extension in individuals with autism, we hypothesize an atypical mapping of novel labels to novel objects, regardless of the physical properties of the objects. In Experiment 1, we demonstrate this phenomenon in some individuals with autism, but the novelty of objects only partially explains their lack of shape bias. In a second experiment, we present a computational model that provides a developmental account of the shape bias in typically developing children and in those with autism. This model is based on theories of neurological dysfunctions in autism, and it integrates theoretical and empirical findings in the literature of categorization, word learning, and the shape bias. The model replicates the pattern of results of our first experiment and shows how individuals with autism are more likely to categorize experimental objects together on the basis of their novelty. It also provides insights into possible mechanisms by which children with autism learn new words, and why their word referents may be idiosyncratic. Our model highlights a developmental approach to autism that emphasizes deficient representations of categories underlying an impaired shape bias.     

Can Explanatory Reasons Be Good Reasons for Action?

What kind of thing is a reason for action? Are reasons for action subjective states of the agent, such as desires and/or beliefs? Or are they, rather, objective features of situations that favor certain actions? The suggestion offered in this article is that neither strategy satisfies. What is needed is a third category for classifying reasons which makes them out to be neither purely subjective nor purely objective. In brief: a reason for action is a feature of the situation that matters to the agent. On this proposal, subjective states of the agent are indeed indispensable in characterizing reasons for action. Precisely which set of situational features matter to an agent—precisely what shape the agent experiences the situation as having—depends on the agent's psychological makeup. Those features themselves are not psychological states, however, and it is precisely those features that constitute the agent's reasons for action.     

Mixed-valence impurity in a nanoscale particle

We consider a mixed-valence Anderson impurity with infinite U embedded into a small metallic particle. The nanosize of the system leads to discrete energy levels rather than to a continuum of energy eigenstates for the host. Using the Brillouin-Wigner approximation we show that the magnetic susceptibility, which arises from the van Vleck admixing of the magnetic configuration into the ground state, is only weakly affected by the finite spacing of energy levels, while the specific heat and the entropy display an exponential activation at low temperatures, that is have properties deviating from a Fermi liquid.     

Annealing of europium-implanted silicon by nanosecond ion-beam pulses

Ion implantation into Si(100) was made with Eu⁺ ions at 25 keV to doses of 1.2 x 10¹⁵ and 1.2 x 10¹⁶ ions cm^-2     

Overvaluation of shape and weight among overweight children and adolescents with loss of control eating

Little is known about the phenomenology of pediatric loss of control (LOC) eating. Overvaluation of shape and weight, however, appears to be diagnostically meaningful among binge eating adults. We explored the significance of shape and weight overvaluation among children and adolescents with LOC eating. Participants (n = 526) included 149 overweight youth with LOC eating and 377 overweight controls (CON). Participants were categorized as those reporting at least moderate overvaluation (LOC-Mod, n = 74; CON-Mod, n = 106) or less than moderate overvaluation (LOC-Low, n = 75; CON-Low, n = 271), and compared on measures of eating-related and general psychopathology. LOC-Mod evidenced lower self-esteem than CON-Low, and greater behavioral problems than CON-Mod and CON-Low, but did not differ from LOC-Low in these domains. With the exception of LOC-Low and CON-Mod, all groups differed on global eating-disorder severity, with LOC-Mod scoring the highest. Overvaluation of shape and weight appears to be of questionable importance in defining subtypes of youth with LOC eating. However, as overvaluation and LOC eating each independently predicts eating-disorder onset, their confluence may confer even further risk for eating-disorder development. Longitudinal studies should address this possibility. Developmentally appropriate discussion about body image disturbance may be indicated in interventions targeting pediatric LOC eating and/or obesity.     

Estimates of shape by eye, or, The little invariant that could

Five experiments were conducted to test the hypothesis that observers apprehend specific constancies under change in perspective. The constancies were projective properties of ellipses pictured to slant and tilt in depth. Observers were asked to reproduce the static upright view of a moving pair of ellipses, using a computer graphics display and interface. Projective invariants for pairs of conics were computed on the observers’ productions. A few experimental conditions revealed near-perfect performance. When pairs of coplanar ellipses were viewed under dynamic transformation in perspective, then invariants calculated on the observers’ productions were a match – in value on average – to the invariants of the transforming ellipse pairs. It is proposed that measures of projective properties afford a family of techniques that can be applied to gauge acuity for complex shapes in the study of visual form perception.     

The Epistemological Status of Vision and its Implications for Design

Computational theories of vision typically rely on the analysis of two aspects of human visual function: (1) object and shape recognition (2) co-calibration of sensory measurements. Both these approaches are usually based on an inverse-optics model, where visual perception is viewed as a process of inference from a 2D retinal projection to a 3D percept within a Euclidean space schema. This paradigm has had great success in certain areas of vision science, but has been relatively less successful in understanding perceptual representation, namely, the nature of the perceptual encoding. One of the drawbacks of inverse-optics approaches has been the difficulty in defining the constraints needed to make the inference computationally tractable (e.g. regularity assumptions, Bayesian priors, etc.). These constraints, thought to be learned assumptions about the nature of the physical and optical structures of the external world, have to be incorporated into any workable computational model in the inverse-optics paradigm. But inference models that employ an inverse optics plus structural assumptions approach inevitably result in a naïve realist theory of perceptual representation. Another drawback of inference models for theories of perceptual representation is their inability to explain central features of the visual experience. The one most evident in the process and visual understanding of design is the fact that some visual configurations appear, often spontaneously, as perceptually more coherent than others. The epistemological consequences of inferential approaches to vision indicate that they fail to capture enduring aspects of our visual experience. Therefore they may not be suited to a theory of perceptual representation, or useful for an understanding of the role of perception in the design process and product.