大鼠注意定势转移任务模型的深入研究：种系和检测程序的影响

注意定势转移任务(attentional set-shifting task, AST)可用于特异性检测啮齿类动物前额叶皮层及其皮层下神经通路介导的认知灵活性, 是目前研究认知灵活性及其障碍神经基础的重要模型。本研究系统调查了大鼠种系和检测程序差异对AST结果的影响。通过比较Wistar和Sprague Dawley (SD)两个种系大鼠在七阶段和五阶段两种AST检测程序中的认知表现, 研究发现：(1) SD和Wistar大鼠前额叶认知功能存在差异, 后者的总体认知表现优于前者。尤其是Wistar大鼠在逆反学习阶段的达标训练次数及错误率显著低于SD大鼠, 表明Wistar大鼠具有更高的策略转换灵活性。(2)在AST测试中逆反学习和外维度定势转移是认知灵活性评价的核心指标。这两种认知转换过程分别以前期策略和注意定势建立为基础。结果显示在两种AST检测程序中Wistar和SD大鼠在逆反学习和/或外维度定势转移等复杂学习阶段的达标训练次数和错误率均高于其它简单关联学习阶段, 表明在目前实验条件下大鼠均表现出定势形成和转换困难的反应模式, 不同认知反应间的结构关系具有稳定性。这些结果提示大鼠前额叶皮质介导的认知灵活性存在种系差异, AST各阶段认知反应间的结构效度不受目前使用的大鼠种系和检测程序差异的影响, 扩展了对AST模型的认识。     

Lateral asymmetry in phonological processing: relating behavioral measures to neuroimaged structures

Recent neuroimaging studies have revealed neuroanatomical centers of activation that appear to be linked specifically to phonological processes. Furthermore, there is evidence that these centers of activation are more likely to be bilaterally represented in women than in men. However, behavioral evidence of such hemispheric asymmetries or of related sex differences is somewhat inconsistent. Two experiments were carried out to determine whether behavioral correlates of the neuroimaging findings could be demonstrated. The first experiment employed a rhyme-matching task used in a recent neuroimaging study, in which two nonsense words were projected successively to the left or right sides of the visual field. The results indicated that the left hemisphere was superior for this task. An analysis of gender effects, however, revealed that the asymmetry was restricted to men. The second experiment employed a lateralized pseudohomophone detection task that was designed to determine whether the results of the first experiment could be confirmed in the context of a phonological task with a simpler structure. This experiment broadly supported the findings of the first experiment. The results support the specialization of the left hemisphere for phonological processing, and the existence of gender differences with respect to these processes.     

Asian and Non-Asian Attitudes Toward Rape,Sexual Harassment,and Sexuality

The purpose of this study was to explore potential differences between Asian and non-Asian university students in attitudes toward coercive and noncoercive sexual behavior. Four hundred women and men (205 Asian, 195 non-Asian) were assessed on attitudes towards rape, sexual harassment, and general sexual behavior. Length of residency in Canada for Asian respondents was examined to determine whether Westernization might attenuate differences. Analysis revealed that Asian students were significantly more conservative in attitudes toward sexual behavior. Asian students were also more tolerant of rape myths and more accepting of sexual harassment. Asian respondents demonstrated a decrease in tolerance for rape myths and sexual harassment as length of residency in Canada increased. Women were less conservative than men from the same background on almost all items.     

Sex differences and estropausal phase effects on water maze performance in aged rats

An age-related decline in memory has been reported in male rats; however, there are few studies that have addressed these changes in aged female rats. In young female rats, hormonal cycles influence behavior. By the age of 22 months most female rats have not had regular hormonal cycles for at least 9 months. In the current study we examined how the hormonal status (persistent estrus and pseudo-pregnant) of the aged (22-24 months) female rat (Long Evans) influenced performance on a spatial version of the Morris water maze and compared this to aged male rats. Aged females in persistent estrus showed better performance on the water maze than both aged females that were pseudopregnant and aged males. Thus, postestropausal hormonal status may influence the course of aging in females.     

Immigrant Sex: the Transport of Affection and Sensuality across Cultures

This paper outlines the ways in which an individual’s notions of sexuality are challenged by immigration. It describes four basic facets of sexuality and the ways in which each are rooted in culture. These include (1) the relative importance of sexuality in daily life; (2) potential or overt homosexuality; (3) marriage—whether based on arrangement or love; and (4) cross-cultural romantic and marital relationships. Immigration can stir up conflicts in each of these realms and lead to defensive retreat into familiar customs or a counterphasic plunge into new cultural avenues. Ideally, it would lead to a working-through of these conflicts and subsequent growth in the immigrant’s understanding of his or her sexual self.     

Racial Differences in Responses to the Caregiver Strain Questionnaire

The aim of this study was to examine differences in responses to the Caregiver Strain Questionnaire (CGSQ) between African American and White caregivers of children with emotional and behavioral challenges. Significant item- and scale-level differences were detected across groups with African Americans consistently reporting less strain. We examined whether these differences were more likely due to nonequivalent measurement than to real differences in the experience of caregiver strain. Confirmatory factor analysis showed that the model fit the data well for both racial groups, but there were some differences in structural components. Internal consistency was equivalent across the groups. In an examination of criterion validity, regression analyses showed that African American caregivers experienced a slower rate of increase in objective caregiver strain at a given increase in child internalizing problems. No other race differences were found in the regression analyses. In general, we conclude that the CGSQ can be useful for detecting caregiver strain and identifying family support needs for both White and African American caregivers. Differences across groups in reports of caregiver strain, however, call for more research on racial differences in the impact on the family of caring for a child with emotional and behavioral disorders.     

Differences in Individual Approaches: Communication in the Familial Breast Cancer Consultation and the Effect on Patient Outcomes

This multicenter study aimed to assess (i) whether individual clinical geneticists and genetic counselors vary in their communication skills and (ii) whether this variation in communication impacts on patient outcomes, such as anxiety, depression, genetics knowledge, and satisfaction. One hundred and fifty women from high-risk breast cancer families attending their first genetic counseling consultation completed pre and post-consultation self-report questionnaires. The consultations were audiotaped and transcribed verbatim. Univariate analyses showed highly significant differences between individual clinical geneticists and genetic counselors in: facilitating understanding (p 0.001); facilitating active involvement (p 0.001); facilitating partnership building (p = 0.003); addressing emotional concerns (p 0.001); and discussing prophylactic mastectomy (p = 0.017). Multivariate linear regressions showed that this variation in communication resulted in a greater change in patients depression 4 weeks after the counseling session (p = 0.017). These findings suggest clinical geneticists and genetic counselors have achieved some standardization in communicating information, but showed diversity in their facilitation skills. Communication skills may be a useful area to explore further in this field.     

Preadolescent Clues to Understanding Depression in Girls

Between the ages of 10 and 15, increases in depression among girls result in a rate that is twice as high as the rate of depression in boys. This sex difference remains throughout early and middle adulthood. Prior to early adolescence, there is essentially no sex difference in the rate of depression. The aim of the present review is to examine whether the preadolescent period is a time during which precursors to depression in girls can be identified. First, existing areas of research on explaining sex differences in depression, including cognitive and affiliative style and the socialization of emotion, are reviewed. Second, the hypothesis that for some girls, preadolescent precursors to depression take the form of excessive empathy, compliance and regulation of negative emotions is articulated. Third, ways of building on existing models by including the proposed preadolescent precursors are proposed. Finally, approaches to testing the hypotheses that individual differences in these domains during preadolescence may explain later individual differences in adolescent onset depression are explored.     

Ritualistic Behavior in Young Children

The aim of this study was to examine ritualistic behavior at its developmental peak. Children 20–59 months of age were sampled through a national system of daycare centers in Israel (N = 228). The order of onset of the ritual behaviors measured was virtually identical to that reported for an American sample (D. W. Evans et al., 1997). Gender and age effects were found for fearfulness but not for ritualistic behavior. Maternal reports of ritualistic behavior were highly correlated with reported fears, and with shy and emotional temperament. Mothers of the children who were in the top 10% in their use of rituals according to maternal report, worried about their child's ritualistic behavior, even though maternal worry was not correlated with ritualistic behavior for the whole distribution.     

Psychoanalysis and Diplomacy: Part III. Potentials for and Obstacles Against Collaboration

Given the pervasive influence of Realpolitik over government and the study of international relations, and some inherent difficulties within the field of psychoanalysis, it is not surprising that political science and psychoanalysis remain distant cousins. Part III in this series on diplomacy and psychoanalysis discusses obstacles against collaboration between these two disciplines, but also points to areas where collaboration is possible and can be useful.