Nonsimultaneous stimulus presentations and their role in listener naming

Previous studies on naming have presented the object and its name simultaneously during both training and testing, and thus the training component may establish a transformation of function directly between the object and the name. Successful tests for listener naming may thus not require the emergence of a novel (entailed) transformation of function. The current study aimed to control for this possibility by presenting the object and the name sequentially and nonsimultaneously. Eight typically developing toddlers participated in the current study. During name training, objects and names were presented nonsimultaneously, and all participants failed to emit listener-naming responses during the first test session. Subsequently, 4 participants received multiple exemplar training, which led to improvements in listener naming for all 4; and speaker naming for only 1 participant. As a control condition, the remaining 4 participants were tested repeatedly, without multiple exemplar training, and did not show any consistent improvements in their listener or speaker performances. Multiple exemplar training thus appeared to be effective in establishing generalized listener responses, which involved generating entailed transformation of functions. The strategy of using nonsimultaneous stimulus presentations could allow for greater precision in identifying the behavioral processes involved in listener-naming.     

振动触觉频率信息的工作记忆容量及存储机制

工作记忆可以同时保存多个信息并且容量有限, 这一内在机制是工作记忆研究的重点问题。视觉和言语等研究领域都发现工作记忆能够存储多个信息单元, 但对振动触觉工作记忆是否能存储多个频率信息目前尚无相关研究。由于振动触觉频率刺激和视觉刺激具有不同的神经编码机制, 以及振动频率信息是通过躯体感觉产生的模拟的、单维的、参数化信息, 振动触觉工作记忆容量及其加工存储机制的研究也必不可少。首先, 本项目将采用新的实验范式, 探究不同的刺激呈现方式以及不同反应报告方式下, 振动触觉工作记忆的容量及其认知机制。其次, 本项目也将同时运用功能磁共振成像(fMRI)技术, 来阐述振动触觉工作记忆加工存储的神经机制。探究基于触觉频率信息的参数工作记忆容量及其神经机制是完善工作记忆模型的重要补充, 将有助于提高我们对工作记忆系统的理解, 并为视觉、听觉、触觉多模态感知觉信息的跨通道研究奠定基础。     

留守学前儿童接受性语言能力与社会退缩的关系:有调节的中介模型

为探讨留守学前儿童接受性语言能力与社会退缩的关系及其内部机制,采用教师评定问卷和测量法对484名留守学前儿童进行调查。结果表明：（1）接受性语言能力不仅对社会退缩具有显著负向预测作用,也能通过执行功能的中介作用负向预测社会退缩;（2）执行功能的中介作用受到师幼关系的调节,相对于高师幼关系水平的个体,间接效应在低师幼关系水平的个体中更为显著,具体而言,师幼关系调节了中介的后半路径;（3）此外,在高师幼关系水平的个体中,执行功能对社会退缩的负向预测作用以及执行功能在接受性语言能力与社会退缩之间的中介作用都不显著。研究结果有助于揭示接受性语言能力对社会退缩的影响及其内在作用机制,对留守学前儿童社会退缩的预防及干预具有一定的启示意义。     

Behind the wheels with autism and ADHD: Brain networks involved in driving hazard detection

Driving is a cognitively challenging task, and many individuals with autism spectrum disorder (ASD) or with attention-deficit/hyperactivity disorder (ADHD) struggle to drive safely and effectively. Previous evidence suggests that core neuropsychological deficits in executive functioning (EF) and theory of mind (ToM) may impact driving in ASD and ADHD. This functional magnetic resonance imaging (fMRI) study compares the brain mechanisms underlying ToM and EF during a hazard perception driving task. Forty-six licensed drivers (14 ASD, 17 ADHD, 15 typically developing (TD)), ages 16–27 years, viewed a driving scenario in the MRI scanner and were instructed to respond to driving hazards that were either “social” (contained a human component such as a pedestrian) or “nonsocial” (physical objects such as a barrel). All groups of participants recruited regions part of the “social brain” (anterior insula, angular gyrus, right middle occipital gyrus, right cuneus/precuneus, and right inferior frontal gyrus) when processing social hazards, and regions associated with motor planning and object recognition (postcentral gyrus, precentral gyrus, and supplementary motor area) when processing nonsocial hazards. While there were no group differences in brain activation during the driving task, years licensed was predictive of greater prefrontal and temporal activation to social hazards in all participants. Findings of the current study suggest that high-functioning ASD and ADHD licensed drivers may be utilizing similar cognitive resources as TD controls for decisions related to driving-related hazard detection.     

Manipulating parameters of reinforcement to reduce problem behavior without extinction

Differential reinforcement of alternative behavior (DRA) most often includes extinction as a treatment component. However, extinction is not always feasible and it can be counter‐therapeutic if implemented without optimal treatment integrity. Researchers have successfully implemented DRA without extinction by manipulating various parameters of reinforcement such that alternative behavior is favored. We extended previous research by assessing three participants' sensitivities to quality, magnitude, and immediacy using arbitrary responses and reinforcers that maintain problem behavior. The results were used to implement an intervention for problem behavior using DRA without extinction. Our findings indicate that arbitrary responses can be used to identify individual and relative sensitivity to parameters of reinforcement for reinforcers that maintain problem behavior. Treatment was effective for all participants when we manipulated parameters of reinforcement to which they were most sensitive, and, for two participants, the treatment was less effective when we manipulated parameters to which they were least sensitive.     

Efficacy of the Wilbarger Therapressure Program™ to Modulate Arousal in Women with Post-Traumatic Stress Disorder: A Pilot Study Using Salivary Cortisol and Behavioral Measures

This pilot study assesses the efficacy of using the Wilbarger Therapressure Program? to modulate the arousal and influence the sensory symptoms seen in individuals with post-traumatic stress disorder. Salivary cortisol and behavioral measures were used in this single subject design study of four women with post-traumatic stress disorder. Significant positive changes were seen in three of the four the women. The exception was one woman whose post-traumatic stress disorder resulted from blast injuries.     

Sensory Modulation for People with Anxiety in a Community Mental Health Setting

Anxiety is a common mental health issue involving cognitive and physiological hypersensitivity to threat. It negatively affects occupational participation. Sensory modulation intervention aims to use calming sensory input to manage the hypersensitivity and physiological arousal associated with anxiety. The empirical evidence for using sensory interventions for anxiety, however, is limited. This mixed methods single subject case design explored the effectiveness of a 6-week sensory modulation intervention for reducing anxiety and improving occupational participation. Results showed significant reduction in anxiety and improved participation, providing further evidence that sensory modulation is an effective approach for the self-management of anxiety.     

人类大脑结构和功能的性别差异：来自脑成像研究的证据

大脑的性别差异近年来受到了广泛关注。脑成像技术的出现为脑结构和脑功能性别差异的研究开辟了新的道路。借助结构磁共振成像和弥散张量成像等脑结构信息, 以及脑电图、正电子发射断层扫描技术和功能性磁共振成像等脑功能信息, 当前研究主要探讨了脑灰质、脑白质和大脑的基线活动在脑局部区域、脑子系统、全脑连接组三个层次上的性别差异及其在年龄上的发展变化。此外, 为了更好地理解脑性别差异, 当前文章还探讨了脑性别差异研究领域的一些认识误区。有关脑性别差异的研究虽然已经取得了丰富的成果, 但现有的研究结果存在很多分歧, 仍然有深入挖掘的空间。未来应该加强对具有性别特异性的心理疾病脑机制的研究, 关注基因和环境对脑性别差异的交互作用, 并利用脑功能活动动态变化的特性、以及结合多模态的脑成像技术进一步阐明脑性别差异。     

'Does Broca's area exist?' Christofredo Jakob's 1906 response to Pierre Marie's holistic stance

In 1906, Pierre Marie triggered a heated controversy and an exchange of articles with Jules Déjerine over the localization of language functions in the human brain. The debate spread internationally. One of the timeliest responses, that appeared in print 1 month after Marie’s paper, came from Christofredo Jakob, a Bavarian-born neuropathologist working in Buenos Aires. The present study comprises an English translation of Jakob’s 1906 paper and a discussion of Jakob’s ideas on the localizationist–holistic approach regarding the role of Broca’s area. This issue is still at the core of scientific debate in the light of current neuropsychological and neuroimaging findings.     

The role of white matter hyperintensities and medial temporal lobe atrophy in age-related executive dysfunctioning

Various studies support an association between white matter hyperintensities (WMH) and deficits in executive function in nondemented ageing. Studies examining executive functions and WMH have generally adopted executive function as a phrase including various functions such as flexibility, inhibition, and working memory. However, these functions include distinctive cognitive processes and not all may be affected as a result of WMH. Furthermore, atrophy of the medial temporal lobe (MTA) is frequently observed in ageing. Nevertheless, in previous studies of nondemented ageing MTA was not considered when examining a relationship between white matter and executive function. The goal of the present study was to examine how WMH and MTA relate to a variety of executive functions, including flexibility, fluency, inhibition, planning, set shifting, and working memory. Strong correlations were observed between WMH and MTA and most of the executive functions. However, only MTA was related to flexibility and set shifting performance. Regression analysis furthermore showed that MTA was the strongest predictor of working memory, after which no further significant association with WMH was noted. Alternatively, both MTA and periventricular hyperintensities independently predicted inhibition performance. These findings emphasize the importance of MTA when examining age-related decline in executive functioning.