No blank slates: Pre-existing schemas about pharmaceuticals predict memory for side effects

Objectives: Attribution of symptoms as medication side effects is informed by pre-existing beliefs about medicines and perceptions of personal sensitivity to their effects (pharmaceutical schemas). We tested whether (1) pharmaceutical schemas were associated with memory (recall/recognition) for side effect information (2) memory explained the attribution of a common unrelated symptom as a side effect.

Design: In this analogue study participants saw the patient leaflet of a fictitious asthma drug listing eight side effects.

Main outcome measures: We measured recall and recognition memory for side effects and used a vignette to test whether participants attributed an unlisted common symptom (headache) as a side effect.

Results: Participants who perceived pharmaceuticals as more harmful in general recalled fewer side effects correctly (r_{Correct Recall} = ?.273), were less able to differentiate between listed and unlisted side effects (r_{Recognition Sensitivity} = ?.256) and were more likely to attribute the unlisted headache symptom as a side effect (r_{side effect attribution} = .381, ps < .01). The effect of harm beliefs on side effect attribution was partially mediated by correct recall of side effects.

Conclusion: Pharmaceutical schemas are associated with memory for side effect information. Memory may explain part of the association between pharmaceutical schemas and the attribution of unrelated symptoms as side effects.     

Sensory processing sensitivity and its relation to parental bonding, anxiety, and depression

Sensory processing sensitivity is a recently proposed construct referring to a tendency to process a variety of information more strongly and deeply than others. Although some research has found links between sensory processing sensitivity and psychological difficulties, highly sensitive people may not necessarily be predisposed to negative affect, but may be more sensitive to poor parenting. Two hundred thirteen college students were given a measure of sensory processing sensitivity (the HSPS), the parental bonding scale (measuring parental care and over-protection), the trait anxiety scale, and the Beck depression inventory. Sensory processing sensitivity predicted both anxiety and depression above and beyond parental factors, indicating that it may be an independent risk factor. An interaction was found between sensory processing sensitivity and parental care when measuring depression. Highly sensitive people may be particularly sensitive to uncaring parents. Results indicate that sensory processing sensitivity may be a temperamental disposition that interacts meaningfully with environmental factors.     

Dimensions of Perfectionism and Anxiety Sensitivity

The current study investigated the extent to which dimensions of perfectionism are associated with components of the anxiety sensitivity construct. A sample of 177 undergraduate students completed the Multidimensional Perfectionism Scale, the Perfectionism Cognitions Inventory, the Perfectionistic Self-Presentation Scale, and the Expanded Anxiety Sensitivity Index developed by Taylor and Cox (1998). The results confirmed that automatic thoughts involving perfectionism and the interpersonal aspects of the perfectionism construct are associated with anxiety sensitivity. Examination of the Anxiety Sensitivity Index factors showed that perfectionism cognitions were associated primarily with anxiety sensitivity involving fears of cognitive dyscontrol, while socially prescribed perfectionism and perfectionistic self-presentation were associated primarily with fears of publicly observable anxiety reactions in a manner suggesting that the interpersonal perfectionism dimensions are linked closely with an anxious sensitivity to negative social evaluation and subsequent panic attacks. The theoretical and treatment implications of the link between perfectionism and anxiety sensitivity are discussed.     

Vigilant self‐regulation,cues of being watched and cooperativeness

The present research examined the interplay of individual differences in self‐regulatory mechanisms as outlined in regulatory focus theory (promotion‐ and prevention‐focus) and a cue of being watched in the context of cooperative behaviour. Study 1 revealed that the more individuals' habitual self‐regulatory orientation is dominated by a vigilant prevention focus, the more likely they are to act cooperatively (i.e. to donate money to natural conservation organizations) when a subtle cue of being watched renders reputational concerns salient. In contrast, when no such cue is provided individuals' habitual vigilant self‐regulatory orientation is negatively related to cooperative behaviour. Study 2 replicated the results of the initial study and examined interpersonal sensitivity (empathic concern) as a potential mediator of the observed effects. Copyright © 2010 John Wiley & Sons, Ltd.     

论战国墨家学派发展的四个阶段

依据墨家学说主旨、队伍组织、从事工作,特别是社会作用的不同,可将战国时期墨家学派的发展分为兴盛(公元前444年至公元前381年)、衰败(公元前381年至公元前311年)、转型(公元前311年至公元前250年)、重兴(公元前250年至公元前221年)四个阶段.兴盛阶段,墨家着力游说诸侯、传播学说、制止攻战、助弱国守城;衰败阶段,墨家学派分化内斗,三派弟子活动转型;转型阶段,“谈辩派”后学热衷于空言思辨,“说书派”后学被视为与儒家同类,“从事派”后学对“任侠之风”产生重大影响;重兴阶段,墨家学派声势复盛,“说书派”后学的宣传,“从事派”后学对墨家精神的继承,“谈辩派”后学与儒家、法家的尖锐争辩,都产生了重大社会影响.     

高渗氯化钠羟乙基淀粉40注射液对肝肿瘤并高血压患者硬膜外复合全身麻醉诱导期的脑保护作用

观察预注高渗氯化钠羟乙基淀粉40注射液对肝肿瘤合并高血压患者硬膜外复合全身麻醉诱导期的脑保护作用。选择50例患有高血压ASA分级Ⅱ级～Ⅲ级肝肿瘤手术患者,随机分为高渗氯化钠羟乙基淀粉40注射液(H)组和复方氯化钠(复方乳酸林格液R)组,每组25例。于输注前(T0)、输注完毕即刻(T1)、气管插管后即刻(T2)、气管插管后5min(T3)、气管插管后15min(T4)、气管插管后30min(T5)抽取静脉血离心后检测血清中S100B、IL-6、TNF-a的浓度。与T0点相比,H组,T5点S100B轻度降低但无统计学差异(P0.05),IL-6、TNF-a无明显变化(P0.05);R组在T5点S100B明显上升(P0.01);IL-6、TNF-a明显上升(P0.05或P0.01)。与R组相比,H组患者在T3-5时点S100B、IL-6和TNF-a均低(P0.05或P0.01)。结论为预注高渗氯化钠羟乙基淀粉40注射液在肝肿瘤合并高血压患者硬膜外复合全身麻醉诱导期具有脑保护作用。     

老年髋部骨折围手术期医疗风险的分析与对策

髋部骨折是老年人的常见病之一,髋部骨折对老年人生命的危害最大。随着人口老龄化,老年髋部骨折发病率呈逐年上升趋势。老年骨质疏松髋部骨折围手术期的医疗风险临床较常见,如何降低老年骨质疏松髋部骨折围手术期的医疗风险,是临床骨科需要解决的问题。分析存在的风险问题,明确各种风险因素,尽可能降低老年髋部围手术期的医疗风险。     

酝酿期有效提示和无效提示的比较

采用中国汉字谜,通过模拟wallas(1926)关于顿悟问题解决的四个阶段,探讨了酝酿期有效提示和无效提示对猜字谜的影响。结果发现：有效提示组被试比无效提示组猜对了更多的靶字谜,反应时也更短;在脑电水平上,酝酿期的有效提示谜比无效提示谜在左前额叶分别于300ms-400ms,400ms-600ms,600ms-800ms内引发了更大的P300-400成分、P400-600成分、P600-800成分。表明有效提示谜比无效提示谜对靶字谜问题的解决有更大促进作用。