Uterus Transplantation: The Ethics of Using Deceased Versus Living Donors

Research teams have made considerable progress in treating absolute uterine factor infertility through uterus transplantation, though studies have differed on the choice of either deceased or living donors. While researchers continue to analyze the medical feasibility of both approaches, little attention has been paid to the ethics of using deceased versus living donors as well as the protections that must be in place for each. Both types of uterus donation also pose unique regulatory challenges, including how to allocate donated organs; whether the donor / donor's family has any rights to the uterus and resulting child; how to manage contact between the donor / donor's family, recipient, and resulting child; and how to track outcomes moving forward.     

Metaphors can give life meaning

Conceptual metaphor theory offers a perspective on how and when people find meaning in life. Whereas life’s meaning can be difficult to grasp, metaphor compares life to a relatively more concrete and structured concept. Supporting this account, American adults (Study 1) and German undergraduates (Study 2) who framed life as a journey reported more meaning in life. The journey metaphor was particularly beneficial for individuals with low levels of perceived coherence in life (Study 2). Study 3 further explored this pattern of moderation: An accessible metaphor, compared to other life framings, benefited participants who lack a strong meaning framework. Study 4 focused on the mechanism behind metaphor’s influence. Participants who imagined events from their life journey perceived stronger interrelatedness among those events as measured with an analog spatial organization task. Perceived interrelatedness in turn predicted meaning in life, particularly for individuals with a strong preference for well-structured knowledge. Finally, participants who applied their own metaphor to life expressed greater meaning (Study 5), especially those high in personal need for structure (Study 6). An internal meta-analysis of these findings provides cumulative evidence for metaphor’s influence on perceived meaning in life and reveals moderating features of the individual.     

A relational recasting of the principles of emotional competence

ABSTRACT

Carolyn Saarni’s theory of emotional competence has made a central contribution by directing attention to some important functions of emotion in social interaction. Her work is permeated with examples of how emotions function within both successful and unsuccessful social interactions and relationships. An examination of her stated principles of emotional competence suggest in places a perspective that is primarily intrapsychic in nature, harking back to the early roots of emotion theory and research. In this piece, we note where Saarni has advanced implications of a relational theory of emotion for understanding emotional competence. In addition, we reframe some of Saarni’s principles to make them more consistent with current relational approaches to emotion. Finally, we offer additions and extensions that we believe are compatible with the general direction of her thinking before her untimely death.     

The neural control of mood: the possible role of the adrenergic system in the medulla

Mood in humans is a complex phenomenon that integrates emotion (e.g. happiness and sadness), cognition, perception, ideation, and action in a coherent manner. In bipolar disorder extremes of mood (up or down) occur outside the normal range, in which all the above functions are coherently affected. Mood is controlled by a series of separate but interactive brain circuits that involve much of the brain, but particularly the limbic system. The question addressed in this paper is whether the coordination of all these separate systems into one coherent functional mood is mediated by non-linear dynamics acting between these systems as equal participants; or whether it is affected by a single master regulator controlling the others. The possible roles, as master regulators, of non-linear dynamically linked populations of neurons, and of the C1–C3 adrenergic nuclei in the medulla is discussed.     

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

Evidence indicates that systemic administration of lipopolysaccharide (LPS) induces brain inflammation, ultimately resulting in cognitive deficits. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, is well known to possess multiple biological functions, including antioxidant, anti-tumor and anti-inflammatory activities. In the present study, we assessed the protective effect of UA against the LPS-induced cognitive deficits in mice. We found that UA significantly improved cognitive deficits of LPS-treated mice in open field, step-through passive avoidance and Morris water maze tasks. One potential mechanism of this action was attributed to the decreased production of pro-inflammatory markers including COX-2, iNOS, TNF-α, IL-1β, IL-2 and IL-6 in LPS-treated mouse brain. Mechanistically, UA markedly inhibited LPS-induced IκBα phosphorylation and degradation, NF-κB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-κB signaling pathways.     

流畅体验、内/外动机、数学焦虑及数学成绩的路径分析

目的：研究旨在考察数学学习中的流畅体验,探讨流畅体验、内/外动机、数学焦虑及数学成绩的关系。方法：招募296名高中生,在数学月考后完成自编考试流畅体验量表、学习动机量表、数学焦虑量表。结果：路径分析表明,存在四条显著路径,即内部动机→流畅状态→数学成绩;数学焦虑→流畅状态→数学成绩;外部动机→流畅状态→数学成绩;外部动机→数学成绩。结论：只有通过考试过程中的流畅体验,内部动机和数学焦虑才能影响考试成绩。     

Addition through subtraction: Growth following the dissolution of a low quality relationship

Previous research has primarily focused on negative outcomes following relationship dissolution. The purpose of this study is to add to the growing literature that shows the positive outcomes that are possible. It was hypothesized that growth and positive emotions would be associated with self-related variables such as self-expansion and rediscovery of self, as well as coping strategies. Participants were 155 undergraduates who had experienced the dissolution of a relationship in the past 6 months. Results confirmed the hypotheses that growth would be related to ending a relationship low in self-expansion and that the relationship between these variables would be mediated by experiencing more rediscovery of the self, less loss of self, and more positive emotions following dissolution.     

Suicide bombings and the self

The failure to locate a unifying psychological profile of suicide bombers should prompt moves to a more extended and interdisciplinary front, availing itself of insights from disciplines such as sociology, philosophy and history of ideas, as well as from psychology. This paper aims in that direction by exploring ‘traditional’ versus ‘western liberal’ conceptions of the self, with special emphasis on their possible pathologies; and by integrating those pathologies with insights from Durkheimian suicidology. It is hypothesised that suicide bombers in the West are typically callow, malleable young men targeted by terror merchants, and that their suicide missions are, first and foremost, acts of deluded self-enhancement, which need to be understood against the backdrop of the western liberal conception of the self. Finally, some implications for moral education are suggested.     

Self-construal priming modulates the scope of visual attention

Although it is well documented that cultures influence basic cognitive processes such as attention, the underlying mechanisms remain unclear. We tested the hypothesis that self-concepts that characterize people from different cultures mediate the variation of visual attention. After being primed with self-construals that emphasize the Eastern interdependent self or the Western independent self, Chinese participants were asked to discriminate a central target letter flanked by compatible or incompatible stimuli (Experiment 1) or global/local letters in a compound stimulus (Experiment 2). Experiment 1 showed that, while responses were slower to the incompatible than to the compatible stimuli, this flanker compatibility effect was increased by the interdependent relative to the independent self-construal priming. Experiment 2 showed that the interdependent-self priming resulted in faster responses to the global than to the local targets in compound letters whereas a reverse pattern was observed in the independent-self priming condition. The results provide evidence for dynamics of the scope of visual attention as a function of self-construal priming that switches self-concept toward the interdependent or independent styles in Chinese.     

Evidence for a role of the responding agent in the joint compatibility effect

The present study explored the role of the responding agent in a social context. To do so, we developed a compatibility task with socially relevant but task-irrelevant stimuli (own face, neutral face, and a friend's face). Participants were required to perform naming responses to coloured diamonds, while the faces were presented as irrelevant stimuli. We observed faster responses in face–name compatible than in incompatible conditions. When the task was distributed among two friends, we observed a compatibility effect in a joint go/no-go condition, in which both participants performed their go/no-go tasks together. In contrast, no compatibility effect was obtained in an individual go/no-go condition. Further, the experiment showed that this joint compatibility effect was based on the compatibility between the irrelevant face and the responding agent. This result demonstrates that features of the responding agent play a crucial role in the joint compatibility effect.