Shared timing variability in eye and finger movements increases with interval duration: Support for a distributed timing system below and above one second

The origins of the ability to produce action at will at the hundreds of millisecond to second range remain poorly understood. A central issue is whether such timing is governed by one mechanism or by several different mechanisms, possibly invoked by different effectors used to perform the timing task. If two effectors invoke similar timing mechanisms, then they should both produce similar variability increase with interval duration (interonset interval) and thus adhere to Weber's law (increasing linearly with the duration of the interval to be timed). Additionally, if both effectors invoke the same timing mechanism, the variability of the effectors should be highly correlated across participants. To test these possibilities, we assessed the behavioural characteristics across fingers and eyes as effectors and compared the timing variability between and within them as a function of the interval to be produced (interresponse interval). Sixty participants produced isochronous intervals from 524 to 1431?ms with their fingers and their eyes. High correlations within each effector indicated consistent performance within participants. Consistent with a single mechanism, temporal variability in both fingers and eyes followed Weber's law, and significant correlations between eye and finger variability were found for several intervals. These results can support neither the single clock nor the multiple clock hypotheses but instead suggest a partially overlapping distributed timing system.     

The Limits of Reproductive Decisions

In this article I will address the question of determining the moral limits of reproductive decisions. In so doing I will examine the contributions made by John Harris, who has over the years consistently addressed the ethical implications of advancing reproductive technologies. In addressing these matters, Harris has centred his arguments on the principle of harm and with this in mind has set out a specific theoretical framework from which decisions about disability and causing harm, as in the case of reproductive decisions, can be rationally addressed. This discussion will attempt to question the conceptual scheme that he proposes. The aim here is not to present an alternative theoretical contribution to the morality of reproductive choice. Rather, in the attempt to follow some of the directives in Wittgenstein’s later philosophy, the aim is to demonstrate some of the pitfalls of what Wittgenstein has described as the “craving for generality” in contemporary philosophy. I propose that this craving can distort, in this instance, our ordinary usage of concepts such as harm, suffering and disability and their role in the moral vocabulary of reproductive decision making     

Non-ligand activation of estrous behavior in rodents: cross-talk at the progesterone receptor

Estrous behavior in rodents is triggered by the binding of progesterone (P) to its intracellular receptor (PR). Non-steroidal agents (i.e., gonadotropin-releasing hormone, noradrenaline, dopamine and others), acting at the membrane, can facilitate estrous behavior in estrogen-primed rats. This action is mediated through the generation of second messengers (cyclic AMP, cyclic GMP, calcium) which, in turn, phosphorylate through diverse kinase systems (protein kinases A, G or C) either the PR or associated effector proteins linking the PR to the trans-activation machinery. P or its metabolites also activate cyclic AMP-signaling pathways by acting directly on the membrane or by modulating neurotransmitter release. Molecular processes resulting from second messenger signaling pathways and those from the progesterone-RP interaction synergize to elicit a full behavioral response.     

Contributions to factor analysis of dichotomous variables

A new method is proposed for the factor analysis of dichotomous variables. Similar to the method of Christoffersson this uses information from the first and second order proportions to fit a multiple factor model. Through a transformation into a new set of sample characteristics, the estimation is considerably simplified. A generalized least-squares estimator is proposed, which asymptotically is as efficient as the corresponding estimator of Christoffersson, but which demands less computing time.This research was supported by the Bank of Sweden Tercentenary Foundation under project Structural Equation Models in the Social Sciences, project director Karl G. Jöreskog.     

Deconstructing the Doctrine of Double Effect

This paper examines the doctrine of double effect as it is typically applied. The difficulty of distinguishing between what we intend and what we foresee is highlighted. In particular, Warren Quinn's articulation of that distinction is examined and criticised. It is then proposed that the only credible way that we can be said to foresee that a harm will result and mean something other than that we intend it to result, is if we are not certain that that harm will result. The ramifications of this are explored. The paper concludes with a moral evaluation of a variety of cases that have harmful outcomes. It is recommended both that we abandon the doctrine of double effect and that we cease to describe cases with harmful outcomes in a dishonest way.     

Helping behaviour among people who use drugs: Altruism and mutual aid in a harm reduction program

People who use drugs, and particularly people experiencing addiction, are rarely afforded the opportunity to have their voices heard when it comes to drug treatment or drug policy or even when attempting to define themselves and their life experiences. Of course, there is much more to a person than one area of their behaviour. The current study seeks to capture and understand the lived experiences of people who use drugs, with a focus on their relationships and helping behaviour. We interviewed 32 participants in a harm reduction program seeking to provide understanding beyond stigmatizing and criminalizing drug narratives, by exploring their motivation and context for helping behaviours. Grounded theory methodology was used to understand the patterns of helping behaviour, along with the contexts in which help is or is not given. We particularly focus on participants' distribution of syringes and carrying medicine to reverse overdose (naloxone). Participants shared stories of altruism and mutual aid, along with barriers and disincentives to helping others. We situate these behaviours within contrasting environments of a free harm reduction program and the competitive market system of the U.S. society. Implications for practice and public policy are discussed.     

Roger T. Kelleher, behavior analyst

Roger T. Kelleher, rightly known as one of the foremost contributors to behavioral pharmacology, also made many important contributions to the experimental analysis of behavior. He participated significantly in the development of the discipline, through both his research and his editorial contributions to thisjournal. This article summarizes his contributions to the field of behavior analysis. His most significant empirical and conceptual contributions to behavior analysis came in two domains-conditioned reinforcement and the power of schedules of reinforcement. His accomplishments in these two domains still serve as principal foundations for modern research and theory.     

What's different in second-language processing? Evidence from event-related brain potentials

German sentences which were either correct, contained a selectional restriction violation, or a word category violation were presented auditorily to 16 native speakers of German (L1 group) and to 16 native speakers of Russian, who had learned German after the age of 10 (L2 group). Semantic violations elicited an N400 effect for both groups, but with a reduced amplitude and a longer peak latency in the L2 group. Compared to correct sentences, sentences with a phrase structure violation elicited an early anterior negativity followed by a broad centro-parietal positivity in native speakers. By contrast, there was no differential modulation of the early anterior negativity in the L2 group. A late positivity was also elicited in the second language learners, but it was slightly delayed compared to that shown by native speakers. This pattern is discussed in terms of different degrees of automaticity with respect to the subprocesses involved in sentence comprehension.     

Antenatal Genetic Testing and the Right to Remain in Ignorance

As knowledge increases about the human genome,prenatal genetic testing will become cheaper,safer and more comprehensive. It is likelythat there will be a great deal of support formaking prenatal testing for a wide range ofgenetic disorders a routine part of antenatalcare. Such routine testing is necessarilycoercive in nature and does not involve thesame standard of consent as is required inother health care settings. This paper askswhether this level of coercion is ethicallyjustifiable in this case, or whether pregnantwomen have a right to remain in ignorance ofthe genetic make-up of the fetus they arecarrying. While information gained by genetictesting may be useful for pregnant women whenmaking decisions about their pregnancy, it doesnot prevent harm to future children. It isargued that as this kind of testing providesinformation in the interests of the pregnantwomen and not in the interests of any futurechild, the same standards of consent that arenormally required for genetic testing should berequired in this instance.