合成生物学伦理问题研究态势分析

合成生物学以创造新型生物为目标,这一领域的飞速发展在给人类带来巨大福祉的同时,也陆续引发众多伦理问题。利用VOSviewer等科学计量工具对国内外合成生物学伦理领域2000年~2019年近20年的相关研究文献进行量化分析,通过对时间分布、地域分布、关键词共现、研究方向等数据的系统分析,进一步对国内外学者、专家的应用研究成果与伦理思考进行总结概括,并对合成生物学伦理问题的研究趋势提出展望,以图廓清国内外合成生物学伦理问题研究的发展态势。     

RELIGION AND FRANCIS BACON'S SCIENTIFIC UTOPIANISM

Francis Bacon often is depicted as a patriarch of modernity who promotes human rational action over faith in divine Providence and as a secular humanitarian who realized that improvement of the human condition depended on human action and not on God's saving acts in history. Bacon's New Atlantis is usually described as a “scientific utopia” because its ideal order, harmony, and prosperity are the result of the investigations of nature conducted by the members of Solomon's House. I challenge these characterizations by showing that Bacon's so‐called scientific utopianism is grounded in his religious convictions that his age was one of Providential intervention and that he was God's agent for an apocalyptic transformation of the human condition. I examine the centrality of these religious themes in two of his philosophical works, The Advancement of Learning and The Great Instauration, which are well known for setting out Bacon's critique of the state of learning and for presenting the principles of his epistemology. Analysis of The Advancement of Learning demonstrates Bacon's conviction that his reform of natural philosophy was part of a Providentially guided, twofold restoration of the knowledge of nature and the knowledge of God. Examination of The Great Instauration reveals that Bacon sees his age as one of apocalyptic transformation of the human condition that restores humanity to a prelapsarian state. Analysis of the New Atlantis shows that utopian perfection can be achieved only through a combination of right religion and the proper study of nature. Moreover, when the “scientific” work of Solomon's House is recontextualized within the religious themes of salvation and deliverance that permeate the New Atlantis, the full scope of Bacon's “scientific utopianism” can be seen, and this project is not the one usually portrayed in scholarly treatments. Bacon's program for rehabilitating humanity and its relation to nature is not a secular, scientific advance through which humanity gains dominion over nature and mastery of its own destiny but rather one guided by divine Providence and achieved through pious human effort.     

Sellars's Two Images as a Philosopher's Tool

The distinction between the manifest and the scientific image of man‐in‐the‐world is widely seen as crucial to Wilfrid Sellars's philosophical work. The present essay agrees with this view. It contends, however, that precisely because the distinction is important, we should not hurry to a quick and superficial understanding of it. The essay identifies several oversimplifications that can be found in the literature on the topic and argues that they are at least partly rooted in too rigid a view of the role that the two‐image distinction plays in Sellars's philosophy. It shows that this rigid approach is quite common in the secondary literature, either explicitly or by implication. It then presents a more cautious, flexible approach to the problem of the two images and explains why this approach is fruitful on the basis of textual evidence, along with the overall advantages of interpreting Sellars's thought as a whole.     

The Solubility of Salt: A Divine Action Account

In the burgeoning literature on dispositions, solubility is a standard example. In this paper we give a rigorous theistic divine action account of the simple mechanism of the dissolving of salt, NaCl, into the ions Na⁺ and Cl^?. We explore this reaction in terms of an alternative view of divine action, Divine Compositionalism, which holds that the functioning of every physical, chemical, and biological mechanism in the universe is a manifesting complex disposition, which is nothing other than ways God acts according to plan.     

The acquisition of scientific knowledge: the influence of methods of questioning and analysis on the interpretation of children's conceptions of the earth

Studies of children's knowledge of the Earth have led to very different conclusions: some appear to show that children construct their own, non‐scientific ‘theories’ (mental models) of the flat, hollow or dual Earth. Others indicate that many young children have some understanding of the spherical (scientific) Earth, and that their knowledge lacks the coherence of mental models. The reasons for these contrasting views were tested by interviewing French children (N = 178) aged 5–11 years and varying the different methods used in previous research, namely the types of questions (open and forced‐choice), the form of representation (two‐dimensional pictures and three‐dimensional models), and the method of analysis (the mental model theorists' coding scheme and a statistical test for associations using MANOVA). Forced‐choice questions resulted in higher proportions of scientific answers than open questions, and children appeared to have naïve mental models of the Earth only when the mental model theorists' coding scheme was used. These findings support the view that children tend to have ‘fragments’ of scientific knowledge, and that naïve mental models of the Earth are methodological artifacts. Copyright © 2011 John Wiley & Sons, Ltd.     

MARTIN LUTHER'S EXPERIENTIAL THEOLOGY AS A MODEL FOR FAITH-SCIENCE RELATIONSHIPS

The approach of experiential realism could indicate where science and faith deal with the same reality, where science questions faith assumptions, and where faith goes beyond the mandate and method of science. Although prescientific, Martin Luther's theology is the classical prototype of an experiential theology. We experience God's creative power in all of reality. We discern its regularities through observation and reason. So faith opens up all the space needed by science. However, experienced reality is highly ambiguous. It obscures God's intentions. God's intentions are revealed in the proclamation of the gospel: God is unconditionally for us and with us and not against us. This proclamation is a promise, appropriated in faith, and geared to a vision of what ought to become. It is based on the interpretation of a catastrophe—the cross of Christ—as God's pivotal redemptive act in human history. It goes beyond the mandate and method of science, yet it is capable of giving the latter a sense of purpose, criteria of acceptability, and authority to act in the interests of humanity and the earth. Theology challenges science to acknowledge the necessity of a transcendent frame of reference and moral accountability. Scientific insight challenges theology to reconceptualize its assumptions on God, creation, and eschatology to integrate best science.     

Scientific information and uncertainty: Challenges for the use of science in policymaking

Science can reinforce the healthy aspects of the politics of the policy process, to identify and further the public interest by discrediting policy options serving only special interests and helping to select among “science-confident” and “hedging” options. To do so, scientists must learn how to manage and communicate the degree of uncertainty in scientific understanding and prediction, lest uncertainty be manipulated to discredit science or to justify inaction. For natural resource and environmental policy, the institutional interests of government agencies, as well as private interests, pose challenges of suppression, over-simplification, or distortion of scientific information. Scientists can combat these maneuvers, but must also look inward to ensure that their own special interests do not undermine the usefulness of science.     

Scientific Realism and the Meanings of Theoretical Terms

In contemporary philosophy of science, there are many interesting arguments for and against scientific realism with regard to the meaningfulness and truthfulness of theoretical statements. Some anti-realists hold that since many important concepts in scientific theories have no specific referents, the relevant theoretical statements are therefore either false or meaningless. In this essay, I join the debates concerning the plausibility of scientific realism by focusing on two intertwined issues： first, that of how we can we explicate the meaningfulness of theoretical statements, especially statements pertaining to unobservable objects, and second, that of the meaningfulness of theoretical statements for our acceptance of scientific realism.     

Scientific Discovery on Positive Data via Belief Revision

A model of inductive inquiry is defined within a first-order context. Intuitively, the model pictures inquiry as a game between Nature and a scientist. To begin the game, a nonlogical vocabulary is agreed upon by the two players along with a partition of a class of structures for that vocabulary. Next, Nature secretly chooses one structure (the real world) from some cell of the partition. She then presents the scientist with a sequence of atomic facts about the chosen structure. With each new datum the scientist announces a guess about the cell to which the chosen structure belongs. To succeed in his inquiry, the scientist's successive conjectures must be correct all but finitely often, that is, the conjectures must converge in the limit to the correct cell. A special kind of scientist selects his hypotheses on the basis of a belief revision operator. We show that reliance on belief revision allows scientists to solve a wide class of problems.     

Misconduct in science and the german law

In the past, only norms and rules developed for other types of illegal activities could be applied to misconduct in science in Germany. But only particularly blatant cases of misconduct can be dealt with efficiently in this way. Nowadays, a couple of very important funding agencies and research institutions have enacted special procedures that apply in cases of suspected scientific misconduct. A strongly decentralised system of dealing with misconduct in science is being established in Germany. An earlier version of this paper was presented at a symposium, Scientific Misconduct. An International Perspective, organised by The Medical University of Warsaw, 16 November, 1998.