The American experience: Lessons learned

This paper discusses ten lessons learned since 1989 about handling allegations of scientific misconduct involving biomedical and behavioral research supported by the U. S. Public Health Service. An earlier version of this paper was presented at a symposium, Scientific Misconduct: An International Perspective, organised by The Medical University of Warsaw, 16 November, 1998. The opinions expressed herein are those of the author and do not necessarily represent the views of the Office of Research Integrity, the U.S. Department of Health and Human Services, or any other federal agency.     

Auguste Comte on Positivism and Happiness

Auguste Comte (1798–1857) is the founder of a French school of thought that became famous for its encyclopaedic account of the sciences as well as for its exposition of what was designed as a way out of a state of intellectual and moral crisis. This essay demonstrates that there is a linkage between the diagnosis of crisis and the pursuit of happiness in Comte's foundation of positivism. It begins by distinguishing Comte's notion of positivism from that of a value-free science. In analysing Comte's peculiar usage of the term happiness, the essay shows that happiness is understood as the result of the convergence (consensus) of three components: a scientific conception of the world, the feelings of love and veneration, and a wisely ordered activity. The essay then demonstrates that the first of these components is of primary importance inasmuch as it is to frame a new horizon within which man is expected to return to a healthy state of mind, to reshape both his hopes and activities, and to discover his own participation in a supreme order acting through the laws of nature as well as through those of the civilization in which he lives. Conveying this new horizon to citizens of a lasting Republic is the sacred mission of sociology. The essay concludes by pointing out that Comte's conception of happiness can be assessed as unifying some main qualities of life as they are classified in Ruut Veenhoven's fourfold matrix.     

Confirmation of Scientific Hypotheses as Relations

Summary  In spite of several attempts to explicate the relationship between a scientific hypothesis and evidence, the issue still cries for a satisfactory solution. Logical approaches to confirmation, such as the hypothetico-deductive method and the positive instance account of confirmation, are problematic because of their neglect of the semantic dimension of hypothesis confirmation. Probabilistic accounts of confirmation are no better than logical approaches in this regard. An outstanding probabilistic account of confirmation, the Bayesian approach, for instance, is found to be defective in that it treats evidence as a formal entity and this creates the problem of relevance of evidence to the hypothesis at issue, in addition to the difficulties arising from the subjective interpretation of probabilities. This essay purports to satisfy the need for a successful account of hypothesis confirmation by offering an original formulation based on the notion of instantiation of the relation urged by an hypothesis.     

Forms of Quantum Nonseparability and Related Philosophical Consequences

Standard quantum mechanics unquestionably violates the separability principle that classical physics (be it point-like analytic, statistical, or field-theoretic) accustomed us to consider as valid. In this paper, quantum nonseparability is viewed as a consequence of the Hilbert-space quantum mechanical formalism, avoiding thus any direct recourse to the ramifications of Kochen-Specker’s argument or Bell’s inequality. Depending on the mode of assignment of states to physical systems – unit state vectors versus non-idempotent density operators – we distinguish between strong/relational and weak/deconstructional forms of quantum nonseparability. The origin of the latter is traced down and discussed at length, whereas its relation to the all important concept of potentiality in forming a coherent picture of the puzzling entangled interconnections among spatially separated systems is also considered. Finally, certain philosophical consequences of quantum non-separability concerning the nature of quantum objects, the question of realism in quantum mechanics, and possible limitations in revealing the actual character of physical reality in its entirety are explored.     

Ethical issues at the university-industry interface: A way forward?

This paper forms an introduction to this issue, the contents of which arose directly or indirectly from a conference in May 2001 on Corruption of scientific integrity? — The commercialisation of academic science. The introduction, in recent decades, of business culture and values into universities and research institutions is incompatible with the openness which scientific and all academic pursuit traditionally require. It has given rise to a web of problems over intellectual property and conflict of interest which has even led to corporate sponsors’ suppressing unfavourable results of clinical trials, to the detriment of patients’ health. Although there are those who see the norms of science developing to recognise the importance of instrumental science aiming at specific goals and of knowledge judged by its value in a context of application, none justifies the covert manipulation of results by vested interest.Public awareness of these problems is growing and creating a climate of opinion where they may be addressed. We suggest a way forward by the introduction of nationally and internationally-accepted guidelines for industrial collaboration which contain proper protections of the core purposes of universities and of the independence of their research. Some codes suggested for this purpose are discussed. We note that some universities are moving to adopt such codes of conduct, but argue the need for strong support from the government through its funding bodies.     

Shackling the shoulders of giants

This paper informally summarizes a two-day symposium held at the U.S. National Academy of Sciences in Washington, D.C., September 5–6, 2002. The issue was to what extent the progress of science and societal capacity for continued technological innovation are threatened by excessive protection of intellectual property. Excessive protection creates disadvantages not only for scientists and inventors but also for educators/students and for librarians/clientele. Speakers from a variety of disciplines and institutions agreed unanimously that scientific and technological progress is, indeed, under serious threat. Various opinions were expressed about the degree of threat, currently and prospectively, as well as what counter-measures are best suited to resist undue restrictions on creative uses of scientific and technical data and information. This summary is based entirely on the author’s notes from the symposium, and the commentary offered is his alone. My apologies to the speakers if this paper does not accurately reflect the primary intent of their presentations. The “Suggested Readings” offered at the end are not specific to the speakers’ statements but rather are offered as a general resource to aid further research. The definitive record of the symposium is planned to be available from the National Academies Press as a Proceedings publication in the summer of 2003. John Gardenier is an independent researcher, ethicist and science writer.     

Shaping the Field of Theology and Science: A Critique of Nancey Murphy

Nancey Murphy is a key second-generation figure in the field of religion and science. Through a variety of responsibilities, some of which are reviewed here, she has worked as a discipline builder over the last fifteen years. After trying to convey the general spirit of Murphy's work, the author focuses on five areas where readers might resist her conclusions, including her "postmodern" theory of scientific (and religious) knowledge and truth, her treatment of theology and science as "separate but equal," and her defense of physicalism.     

Discovering the Alphabetic Principle: A Lost Opportunity for Educational Reform

We review the recently published report by the Committee on the Prevention of Reading Difficulties in Young Children from a behavior analytic perspective. The authors prescribe what children should learn to be successful readers based on the correlates of reading and the developmental progression of reading errors. The report offers no discussion of theoretical models that can be used by teachers and parents to reform reading instruction or specific procedures that have been shown to be effective at promoting various reading skills. We discuss these omissions in terms of the level of research included in the review, the authors' structural approach to synthesizing this research, and the constructivist orientation common to many early childhood educators. The paper concludes by identifying models and strategies from the behavior analysis literature that can be used to guide instruction and offers a modest suggestion for future reviews of reading research.     

Changing explanatory frameworks in the U.S. government’s attempt to define research misconduct

Nearly two decades of debate have not settled the definition of research misconduct. The literature provides four explanatory frameworks for misconduct. The paper examines these frameworks and maps them onto efforts by the U.S. Public Health Service to define research misconduct and subsequent responses to these efforts by the scientific community. The changing frameworks suggest that closure will not be achieved without an authoritative effort, which may occur through the Research Integrity Panel’s recent attempt to create a government-wide definition.