用科学的证据和科学的管理指引心血管疾病的防治

心血管疾病的防治不仅仅是心血管医生的问题,还是一个在循证医学引领下的一个全民生活方式改变的问题,也需要多学科相关专业的联盟,涉及心血管疾病治疗规范的形成与普及,对于疾病发生、发展各个阶段的科学管理更是冠心病的防治效果的重要保障。本文针对心血管病冠心病预防的具体实施,从几方面打开了一个全新的视野。     

浅析当前临床科学决策的几个影响因素

随着循证医学在我国的发展和"医疗举证责任倒置"等相关法律的实施,我国临床医生在进行诊治决策时已逐步向临床科学决策迈进。而防御性医疗、不健全的医疗制度及相关法律等却严重影响着这一科学决策的转变过程。只有有效解决了导致干扰科学决策的各种社会影响因素,如扩大基本医疗保险的覆盖率,实施医疗风险保险制度,提高医务人员认知和职业素质,保障行医安全等,临床科学决策的真正落实就大有希望。     

Animal Mind: Science,Philosophy, and Ethics

Although 20^th-century empiricists were agnostic about animal mind and consciousness, this was not the case for their historical ancestors – John Locke, David Hume, Jeremy Bentham, John Stuart Mill, and, of course, Charles Darwin and George John Romanes. Given the dominance of the Darwinian paradigm of evolutionary continuity, one would not expect belief in animal mind to disappear. That it did demonstrates that standard accounts of how scientific hypotheses are overturned – i.e., by empirical disconfirmation or by exposure of logical flaws – is inadequate. In fact, it can be demonstrated that belief in animal mind disappeared as a result of a change of values, a mechanism also apparent in the Scientific Revolution. The “valuational revolution” responsible for denying animal mind is examined in terms of the rise of Behaviorism and its flawed account of the historical inevitability of denying animal mentation. The effects of the denial of animal consciousness included profound moral implications for the major uses of animals in agriculture and scientific research. The latter is particularly notable for the denial of felt pain in animals. The rise of societal moral concern for animals, however, has driven the “reappropriation of common sense” about animal thought and feeling.     

An investigation of the psychometric evidence of CBM-R passage equivalence: Utility of readability statistics and equating for alternate forms

Claims have been made that grade appropriate curriculum-based measurement of reading (CBM-R) passages are of comparable difficulty and can be used interchangeably to monitor student progress. Empirical evidence to support claims of equivalence has been lacking. This research investigated the basis for making claims of equivalence. The use of readability statistics to justify passage equivalence was found to be lacking. Using a general measurement model for congeneric tests, CBM-R passages were found to measure a single latent factor with a high degree of reliability. However, evidence indicated that the raw scores, words read correctly per minute, across passages did not provide equivalent measurements. Statistical equating was investigated as an approach to overcome the lack of equivalence with promising results.     

A semantics-based approach to the "no negative evidence" problem

Previous studies have shown that children retreat from argument-structure overgeneralization errors (e.g., * Don't giggle me ) by inferring that frequently encountered verbs are unlikely to be grammatical in unattested constructions, and by making use of syntax-semantics correspondences (e.g., verbs denoting internally caused actions such as giggling cannot normally be used causatively). The present study tested a new account based on a unitary learning mechanism that combines both of these processes. Seventy-two participants (ages 5–6, 9–10, and adults) rated overgeneralization errors with higher (* The funny man's joke giggled Bart ) and lower (* The funny man giggled Bart ) degrees of direct external causation. The errors with more-direct causation were rated as less unacceptable than those with less-direct causation. This finding is consistent with the new account, under which children acquire—in an incremental and probabilistic fashion—the meaning of particular constructions (e.g., transitive causative = direct external causation) and particular verbs, rejecting generalizations where the incompatibility between the two is too great.     

科学隐喻的方法论意义

The essential significance of scientific metaphor lies in applying the general metaphorical theory to specific interpretations and elaborations of scientific theories to form a methodology of scientific explanation. It is a contextual grasp of objective reality. A given metaphorical context and its grasp of the essence of reality can only be valid when the context is continually restructured. Taking the context as a whole, the methodological characteristic of scientific metaphor lies in the unity of understanding and choice, experience and concepts, semantic structures and metaphorical domains, rationality and irrationality. As a form of thinking based on reasons, scientific metaphor plays an important role in invention, representation, explanation, evaluation, and communication. Translated by Liu Yiyu from Zhongguo Shehui Kexue 中国社会科学 (Social Sciences in China), 2004, (2): 92–101     

Ways in which coherence is confirmation conducive

Recent works in epistemology show that the claim that coherence is truth conducive – in the sense that, given suitable ceteris paribus conditions, more coherent sets of statements are always more probable – is dubious and possibly false. From this, it does not follows that coherence is a useless notion in epistemology and philosophy of science. Dietrich and Moretti (Philosophy of science 72(3): 403–424, 2005) have proposed a formal of account of how coherence is confirmation conducive—that is, of how the coherence of a set of statements facilitates the confirmation of such statements. This account is grounded in two confirmation transmission properties that are satisfied by some of the measures of coherence recently proposed in the literature. These properties explicate everyday and scientific uses of coherence. In his paper, I review the main findings of Dietrich and Moretti (2005) and define two evidence-gathering properties that are satisfied by the same measures of coherence and constitute further ways in which coherence is confirmation conducive. At least one of these properties vindicates important applications of the notion of coherence in everyday life and in science.     

循证医学及其在心血管疾病中的应用

循证医学作为一门新兴的学科,对医学的研究和实践将产生越来越大的影响。在循证医学的操作过程中,如何正确评价和应用所获得的证据极为重要。在短短的十几年间,循证医学给心血管疾病的临床实践带来了根本的变化。     

Diversity-Based Reasoning in Children

One of the hallmarks of inductive reasoning by adults is the diversity effect, namely that people draw stronger inferences from a diverse set of evidence than from a more homogenous set of evidence. However, past developmental work has not found consistent diversity effects with children age 9 and younger. We report robust sensitivity to diversity in children as young as 5, using everyday stimuli such as pictures of objects with people. Experiment 1 showed the basic diversity effect in 5- to 9-year-olds. Experiment 2 showed that, like adults, children restrict their use of diversity information when making inferences about remote categories. Experiment 3 used other stimulus sets to overcome an alternate explanation in terms of sample size rather than diversity effects. Finally, Experiment 4 showed that children more readily draw on diversity when reasoning about objects and their relations with people than when reasoning about objects' internal, hidden properties, thus partially explaining the negative findings of previous work. Relations to cross-cultural work and models of induction are discussed.