从反义RNA到RNA干扰:科学突破的机遇与创新

RNA干扰是近年发现的存在于真核细胞内的一种重要防御机制,现已发展成为一种全新的基因阻断技术,广泛用于抗病毒、抗肿瘤和后基因组时代基因功能研究.它是在反义RNA研究中意外获得的重大科学突破,其发现过程对科学研究有重要启示意义.     

Pavlovian george windholz (1931–2002): An exemplar of scholarly “observation and observation” and a critical contributor to psychology,and hence to behavioral neuroscience

Although most members of the Pavlovian Society properly focus their efforts on empirical research, the scholarly, critical conceptual contributions of some individuals are also relevant to progress in psychology and behavioral neuroscience. This paper discusses the contributions of the late George Windholz (often in collaboration with Peter Lamal) as: (a) a historian of Pavlov’s life, and work; (b) an analyst of priority issues in psychology as a science; (c) a refuter of myths perpetrated by psychology texts. These contributions provide an example of the scholarly form of the motto “observation and observation,” where the data used to test hypotheses comprise original documents (often in languages other than English) examined by the historian’s critical eye.     

THE COGNITIVE SCIENCE OF RELIGION: IMPLICATIONS FOR THEISM?

Abstract. Although the Cognitive Science of Religion (CSR), a current approach to the scientific study of religion, has exerted an influence in the study of religion for almost twenty years, the question of its compatibility or incompatibility with theism has not been the subject of serious discussion until recently. Some critics of religion have taken a lively interest in the CSR because they see it as useful in explaining why religious believers consistently make costly commitments to false beliefs. Conversely, some theists have argued for the compatibility of religious belief with basic CSR results. In this article, we contribute to the incipient discussion about the worldview relevance of the CSR by arguing that while a theistic reading of the field only represents one interpretative option at most, antitheistic claims about the incompatibility of the CSR with theism look like they may be harder to maintain than first appearances might suggest.     

陌生的邻居:东正教之于中俄相互认知上的障碍性角色

在中俄战略协作伙伴关系的框架下,双方的确没有出现如中美或中国与欧盟之间那样的纷争和冲突,但也缺乏中美、中欧之间相互深刻影响对方的社会进程、经济发展和生活方式变革等积极成果。造成这种矛盾现象的因素固然复杂,但俄罗斯东正教作为远远超出宗教领域的巨大存在,影响着后苏联社会进程的每个方面,却不能被中俄战略协作伙伴关系所考虑,这在客观上必然影响俄中关系,应该是这种战略实施后果不很理想的重要原因。本文探讨两个问题:俄罗斯东正教之于后苏联的超常重要性,以及,中国对俄国的认知绕开东正教因素和无神论政策是不可能的。     

"THEISTIC PSYCHOLOGY AND PSYCHOTHERAPY": A THEOLOGICAL AND SCIENTIFIC CRITIQUE

I take the APA publication A Spiritual Strategy for Counseling and Psychotherapy (Richards and Bergin 2005), along with a devoted issue of Journal of Psychology and Theology (Nelson and Slife 2006), as a paradigmatic example of a trend. Other instances include the uncritical use of "Eastern" philosophy in Humanistic and Transpersonal Psychology, almost normative appeal to the "Sacred" within the psychology of spirituality, talk of "God in the brain" within neurological research, the neologism entheogen referring to psychedelic drugs, and calls for new specializations such as neurotheology and theobiology. In response to the legitimate ethical requirements of respect and openness regarding clients' religious worldviews, the trend is to make God an essential component in psychological theory. The argument is that God is active in the universe and especially in human affairs to such an extent that any accurate account of strictly psychological matters, not just a comprehensive, interdisciplinary purview that could include a distinct theological dimension, must include God as an explanatory factor. Less nuanced than standard theological thought about divine intervention—including a range of opinions from supernaturalism, to occasionalism, to providential and deistic naturalism—this trend would blur the epistemological differences between religion and science by appeal to claimed knowledge sources such as inspiration and revelation and thus undermine the achievements of evidence-based science and establish particularistic religious beliefs as standard explanatory accounts. The concern to include a spiritual, in contrast to a religious or theist, dimension in psychological theory is welcome; but elaborated approaches, such as my own and those of Roberto Assagioli, Viktor Frankl, and Ken Wilber, open to varied theological applications, already exist.     

腹主动脉瘤的外科治疗决策

腹主动脉瘤破裂是最常见、最凶险的疾病之一。提高对其治疗的临床决策水平至关重要。比较传统开腹修复治疗和血管腔内修复治疗的优缺点,以最佳证据为指导,选出最佳方案应用于临床实践。以人为本,做出科学决策,从而降低医疗费用及提高疗效及患者生活质量。     

An Invitation to Behavior Analysts: Review of in Search of Memory: The Emergence of A New Science of Mind by Eric R. Kandel

This fascinating autobiography and multifaceted case history in neuroscience research is accessible to laymen and potentially instructive to working scientists. Kandel takes the reader through his thought processes as he describes experiments that led to some of the past decades'' major neuroscience discoveries (some highlights of which are summarized in the review''s Appendix), and eventually to his Nobel Prize. The review analyzes some of the terminological and conceptual issues that have often inhibited communication between behavior analysts and neuroscientists, with special attention to some of Bennett and Hacker''s admonitions viewed from the perspective of language evolution and linguistics. The review then discusses opportunities for behavior analysts to collaborate with neuroscientists by applying behavioral contingency analysis to help specify the independent variables of neuroscience experiments described by Kandel. Finally, it examines Kandel''s provocative heuristics for locating important research problems, and the lessons that can be gleaned from the book regarding the attributes of potentially great achievers.     

浅谈医学科研思维的逻辑性

医学科研思维过程中最重要的就是医学假说的提出、验证,推理和遵守逻辑思维的过程。它以抽象的概念、判断、推理为思维形式,通过分析、综合、比较、分类等多种逻辑思维方法进行操作,以达到它的最终目的。逻辑思维能力对于医学科研工作者是至关重要的,医学科研工作者应该不断加强逻辑修养,不断提升科研思维水准。     

必须关注防止医学领域内的唯心科学观

对医学科学领域内存在的和某些一度充斥的唯心科学观的社会表现进行分析,从过程管理和科学方法论的重要性入手,提出防范学术腐败和发展医学科学的方法和措施,从教育和民生的角度探讨医务工作者和社会学家必须关注的医学领域内的唯心科学观,并举例说明医学工作者的科学道德自律和社会责任感的重要性。     

IMAGINATION'S GRIP ON SCIENCE

Abstract: In part because “imagination” is a slippery notion, its exact role in the production of scientific knowledge remains unclear. There is, however, one often explicit and deliberate use of imagination by scientists that can be (and has been) studied intensively by epistemologists and historians of science: thought experiments. The main goal of this article is to document the varieties of thought experimentation, not so much in terms of the different sciences in which they occur but rather in terms of the different functions they fulfil. I argue that thought experimentation (and hence imagination) plays a role not only in theory choice but in singular causal analysis and scientific discovery as well. I pinpoint, moreover, some of the rules governing the use of thought experiments in theory choice and in singular causal analysis, that is, some of the criteria they should meet in order to fulfil those functions successfully.