阿尔茨海默病发病机制的研究进展

阿尔茨海默病是一种起病隐匿,进行性发展的神经系统退行性疾病。临床上以记忆障碍、失语、失用、失认、视空间损害、执行功能障碍以及人格和行为改变等全面性痴呆表现为特征,病因迄今未明,发病机制复杂。本文对可能的发病机制：遗传因素（包括ApoE基因、早老素-1和早老素-2基因,APP基因、α2巨球蛋白基因、TOMM40基因、COL25A1基因）;Aβ代谢（合成、分解、转运）;神经递质学说;自由基与氧化应激学说;金属离子学说等进行综述。     

Towards an Italian model of therapeutic community

In this paper the author reflects on research undertaken by the Association Myth and Reality in the context of the psychiatric reforms in Italy which resulted in the closure of the asylums and the organisation, over the last 20?years, of a network of services in the community. These include thousands of residential units operating on a rehabilitative model. The focus of this paper is on the concept of the therapeutic community as a dynamic evolutionary path, individually tailored to people with different diagnoses and different ages – e.g. psychosis; borderline; adolescents and children. The therapeutic – and more specifically the environmental – factors are presented here. This includes the aesthetics of living and the sensory/emotional climate in relation to the care of the self and protection, regulation and safety, transitional playful climate, everyday life and the sharing implicit in relationships. The emotional climate is a fundamental component that transverses and intersects all the other factors. Treatment is central to the group with its potential for containment and dynamism in relation to relationships, cohesion, belonging, integration of the self in the community and connections with social networks outside the group aimed at reintegration into society of the resident as a citizen. A system of evaluation through peer reviews between therapeutic communities in Italy is being built in order to continuously improve the quality of service delivery.     

When God Smites: Talking with Students about the Violence of God in Scripture

This article emphasizes the need for religious educators to address the issue of divine violence in Scripture with students, and it offers various pedagogical strategies for doing so. The focus is on violent Old Testament texts, with special attention given to the issue of Canaanite genocide. A general framework for structuring class time around divine violence in Scripture is proposed which includes (1) encouraging students to encounter violent biblical texts firsthand, (2) helping them understand why people find these passages problematic, and (3) offering various options for dealing with the potential problems these passages raise. In the second half of the article, significant attention is devoted to a number of practical considerations that should be taken into account when talking about this sensitive issue in class. A brief word about assessment is offered at the end.     

School‐based humanistic counselling for psychological distress in young people: A practice research network to address the attrition problem

Aims: School‐based humanistic counselling (SBHC) is a common psychological intervention for young people, particularly in the UK. However, studies have tended to suffer from high attrition rates, such that effects may have been over‐estimated. This paper describes a low budget ‘star topology’ practice research network (PRN) outcome evaluation of SBHC in a sample where attrition rates were minimised. Design: A practice‐based longitudinal study in a small PRN compared levels of psychological distress at first and last session from session‐by‐session data. Multilevel regression modelling was used to identify predictors of outcomes. Methods: Eight counsellors working across 11 schools agreed to use session‐by‐session self‐rating on the Young Person's CORE (YP‐CORE) yielding data from 256 young people aged 11 to 17. Predictors of outcomes were analysed using multilevel regression analysis. Results: Mean levels of distress on the YP‐CORE reduced from 18.29 (SD = 7.32) at baseline to 9.10 (SD = 6.19) at endpoint, giving a baseline to endpoint effect size of 1.26 (95% CI = 1.06–1.46). Lower levels of psychological distress at endpoint were associated with male clients, younger age groups, greater rates of attendance at counselling, and bereavement as a presenting problem. Conclusions: This ‘star topology’ PRN focused on a single study and demonstrated that such a system can provide relatively low cost, high quality data. The data showed that SBHC is associated with large reductions in psychological distress, and that this cannot be attributed to the high attrition rates of previous datasets.     

Offending Patterns of Serial Sex Offenders: Escalation,De‐escalation,and Consistency of Sexually Intrusive and Violent Behaviours

A series of stranger sexual assaults poses considerable obstacles for law enforcement officials. One such preoccupation is concerned with whether or not the offender will escalate in the severity of his behaviours with subsequent victims. The current study uses transition matrices to address whether or not the offending patterns of 72 serial stranger sex offenders change from one victim to the next as it pertains to their sexual acts and level of physical force used during the crime. Findings indicate that stability, specifically the offender's intrusive sexual acts and use of physical force, and versatility are present in this sample's offending patterns. To explain changes in offending patterns between victims, multinomial regression analyses indicate that situational factors and modus operandi strategies are important considerations. Implications for investigations are discussed. Copyright © 2013 John Wiley & Sons, Ltd.     

普通高中实施选修课的心理认可度及其影响因素——基于宁波市教师与学生群体的调查分析

以宁波市三种类型六所普通中学为样本,以学生群体和教师群体为对象,采用问卷评定法,以心理认可度为指标,探讨了普通中学师生对于实施选修课制度的主观评价及其相关因素.结果发现：整体而言,学生和任课教师对宁波市普通高中实施选修课的心理认可度较高;存在的主要问题,是学生对选修课学习效果的认可度较低,而教师对学校开展选修课的教学条件的认可度较低,且认为实施选修课制度的外部阻力较大;特色类和融通类学校落实选修课制度的观念性阻力较大;中老年教师对开设选修课的适应性较低.进一步完善选修课制度,需要从教师、学校和政府三个方面形成合力,共同推动旨在促进学生个性化发展的选修课制度的健康发展.     

Event centrality and posttraumatic outcomes in the context of pervasive violence: a study of teachers in El Salvador

It is well established that the importance assigned to a trauma can affect one's recovery and psychological health in numerous ways. Event centrality is an increasingly popular construct that captures the tendency among survivors to reevaluate and possibly accommodate their worldviews posttrauma. The centrality given to trauma appears to serve as a “double-edged sword” in that this construct might factor prominently in both posttraumatic stress disorder (PTSD) and posttraumatic growth (PTG). Focusing on 257 violence-exposed teachers from educational departments throughout El Salvador, we examined whether the centrality assigned by the teachers to stressful life events uniquely predicted both PTSD symptomatology and PTG. Results revealed that event centrality was positively related to both PTSD and PTG, even when controlling for demographic factors, violence exposure, and depression. In addition, PTSD symptomatology and PTG were not associated with one another in this sample. In summary, these findings support the role of event centrality as a contributing factor for PTSD and PTG among persons exposed to pervasive trauma.     

Classroom-based programs of retrieval practice reduce middle school and high school students’ test anxiety

When retrieval practice is applied in classroom settings, do K-12 students experience changes in test anxiety? To answer this question frequently asked by educators, we surveyed 1408 middle school and high school students about their study strategy preferences and their reactions to a classroom-based program of retrieval practice. For classes in which retrieval practice occurred, 92% of students reported that retrieval practice helped them learn and 72% reported that retrieval practice made them less nervous for unit tests and exams. This study is the first to examine the relationship between retrieval practice and classroom test anxiety, and self-reported study strategy use in pre-college students. In light of our results, we encourage K-12 teachers to use retrieval practice in their classrooms to reduce test anxiety and improve learning.