Sensorimotor Impairment of Speech and Hand Movement Timing Processing in Parkinson’s Disease

Models of motor control have highlighted the role of temporal predictive mechanisms in sensorimotor processing of speech and limb movement timing. We investigated how these mechanisms are affected in Parkinson’s disease (PD) while patients performed speech and hand motor reaction time tasks in response to sensory stimuli with predictable and unpredictable temporal dynamics. Results showed slower motor reaction times in PD vs. control in response to temporally predictable, but not unpredictable stimuli. This effect was driven by faster motor responses to predictable stimuli in control subjects; however, no such effect was observed in the PD group. These findings indicated the relationship between PD pathology and sensorimotor deficits in temporal predictive mechanisms of timing processing during speech production and hand movement.     

Parkinson’s disease disrupts both automatic and controlled processing of action verbs

The problem of how word meaning is processed in the brain has been a topic of intense investigation in cognitive neuroscience. While considerable correlational evidence exists for the involvement of sensory-motor systems in conceptual processing, it is still unclear whether they play a causal role. We investigated this issue by comparing the performance of patients with Parkinson’s disease (PD) with that of age-matched controls when processing action and abstract verbs. To examine the effects of task demands, we used tasks in which semantic demands were either implicit (lexical decision and priming) or explicit (semantic similarity judgment). In both tasks, PD patients’ performance was selectively impaired for action verbs (relative to controls), indicating that the motor system plays a more central role in the processing of action verbs than in the processing of abstract verbs. These results argue for a causal role of sensory-motor systems in semantic processing.     

Formal Defensive Aspects of Cognition and Modes of Thinking Exemplified by Freud's Case History of the Rat Man

Autoerotic gratifications are necessary for children suffering from a disturbed mother relation, and constitute symptoms of the same (jactatis capitis, extreme masturbation, etc.). The origins of the autoerotic functions go as far back as the foetal stage (thumbsucking). In the habits of so-called normal human beings, they also have an important stabilizing function to psychic autonomy. We are accompanied by primary and sublimated autoerotic functions all through our lives, which offer comfort and satisfaction during the different vicissitudes of life. Freud's monistic drive theory seems more plausible to me than his later dualistic theories. In accordance with the former, man can regress from object-libidinal cathexes into autoerotic positions when feeling psychically or physically threatened, and during normal conditions when asleep, sleep constituting a normal narcissistic state.     

The impact of role modeling on protégés' personal learning and work-to-family enrichment

The present study investigates the impact of role modeling as perceived by protégés on their personal learning (i.e., relational job learning and personal skill development) and work-to-family enrichment (WFE). Results from a two-wave field survey of 173 protégés in the People's Republic of China indicate that role modeling positively affects relational job learning and personal skill development. However, personal skill development rather than relational job learning was found to be positively related to WFE and to mediate the relationship between role modeling and WFE. The theoretical and managerial implications of these findings are discussed.     

How focus at encoding affects children’s source monitoring

Retention of source information is enhanced by focus on speakers’ feelings about statements even though recognition is reduced for both adults and children. However, does any focus on another person lead to enhanced source monitoring, or is a particular kind of focus required? Does other-focus enhance source monitoring, or does self-focus detract from it? In Experiment 1, 4- and 6-year-olds watched two speakers make statements in a no-focus control or with focus directed on how they (or a speaker) felt about the statements or on perceptual features about themselves (or the speaker). Source monitoring decisions were enhanced by other-focus in both the perceptual and emotional conditions. However, the effect was larger for the emotional condition, and source monitoring exceeded no-focus controls only for this condition. Experiment 2 showed no effect of other-focus versus self-focus on source monitoring when questions were semantic.     

HOW SHOULD WE BEHAVE? A REVIEW OF REASONS AND PERSONS BY DEREK PARFIT

In this book Parfit attempts to develop a rational, non-religious ethics. Instead of asking, “What does God tell us to do?” he asks, “What does reason tell us to do?” Given a set of simple assumptions, he considers whether it is possible to be consistently selfish or consistently good. Analyses of personal dilemmas (problems of self-control) and moral dilemmas (problems of social cooperation) show that neither consistent selfishness nor consistent goodness is logically possible. Instead, a fine balance must be maintained between, on the one hand, our immediate versus long-term good and, on the other, our own good versus that of other people. Ultimately Parfit fails to develop a formula by which such a balance may be struck. Parfit''s analysis is consistent with behavioral analysis in its reductionistic view of the self and the parallel it draws between relations with other people and relations with oneself at other times. Parfit''s analysis is inconsistent with behaviorism in its view of the mind as internal, available to introspection, and able to cause behavior. His nonfunctional mentalism leads Parfit to inconsistencies and blocks the path to a consistent ethics. Teleological behaviorism''s view of the mind in terms of patterns of overt behavior is not hampered by these inconsistencies and may lead to a functional rather than purely rational ethics.     

Schémas cognitifs, croyances addictives et défenses dans la consommation et l’addiction au cannabis de jeunes adultes

Theoretical background

Integrating the cognitive approaches based on the model of Beck et al. (1993) information treatment, the Young (1994) model of maladapted schemas, the integrative approach of Plutchik (1995) and the clinical approach based on defense mechanisms (Bond, 1995), this study aimed at investigating: (a) the role of the hyperactivated maladapted schemas, (b) the addictive beliefs, (c) the suractivation of the conscious derives of defensive mechanisms and (d) the relationships between these cognitive and defensive variables, in young people's cannabis intensity addiction.

Method

Forty-four young adults, 25 females and 19 males, have completed a self-reported questionnaire estimating: (a) the intensity of cannabis addiction (Décamps et al., 2008), (b) the Rusinek (2006) adaptation of Young's maladapted schemas and (c) the questionnaire of addictive beliefs of Tison and Hautekeete (1998) and the defensive styles questionnaire of Bond et al. (1983) and Bond (1995). Non-parametric statistical analysis has been conducted on three subject's groups (“non-users”, “users non addicted”, “users-addicted”) to test the implications and the links between hypothesized psychological factors (e.g., schemas, beliefs and defences) in cannabis use intensity.

Results and discussion

The intensity of cannabis addiction is correlated significantly with: (a) an hyperactivation of three maladapted schemas: inadequate autocontrol, dependence and fear of lose the control, (b) a hyperactivation of permissive, anticipatory and relief oriented beliefs and (c) a higher activation of the defence “sublimation” and a lower activation of the “displacement”. “sublimation” is correlated with the global activation of 13 schemas that are correlated with the positive relief-oriented beliefs, which are correlated with the “displacement” defence, which is correlated with the anticipatory beliefs. The results showed that the permissive beliefs have the power to differentiate the “non-consumption”, the “consumption without addiction” and “the addiction” to cannabis. Our interpretation displays that greater attention to the dysfunctional beliefs will be required in future researches and should be essential targets in cognitive therapy of this substance use disorder.     

Existe-t-il une typologie familiale dans les pathologies addictives ? Revue critique de la littérature sur les familles d’adolescents présentant des troubles alimentaires ou des conduites de dépendance aux substances

Among factors favoring the addictive behaviors, some specific family processes are often identified in eating disorders and dependences with psychoactive substances. Different models of systemic orientation described the familial disturbances involved in the addictive pathologies emphasizing either the emotional interaction and the processes of differentiation family, either the structure and the level of family cohesion. This article proposes a critical review of the systemic literature on the familial disturbances involved in the families of adolescents with eating disorders or with a substance-dependence. The systemic models (Bowen, Minuchin) are reference values in the understanding of family processes and therapy with families. The observations of these family processes have been confronted to empirical researches integrating different epistemological levels and different methods. The empirical results are heterogenous concerning the different forms of family functioning associated with these addictive pathologies. The empirical studies support the hypothesis of a family dysfunctioning in the different addictive behaviors and demonstrate the relationship between the severity of familial disorders and the severity of the addictive disorders. However, the family configuration described by the typological models is rarely found complete or with a similar intensity between the families. The studies support the hypothesis of an emotional distance in the family interactions and a lack of parental care which could correspond to factors of chronicity or vulnerability. Comparing the family characteristics of these two types of addictive behaviors, the literature supports the existence of (1) some specific family characteristics according to the type of addictive behavior (in particular the conflict avoidance which appears specifically in anorexic families) (2) some similar family patterns of interactions between the members of addictive families in particular the representation of a low family cohesion, an intergenerational enmeschment and a high level of control. These family patterns suggest rather to a dimensional approach of the family characterized by different protective or risk factors. We suggest that these family patterns could constitute, according to their importance (intensity and frequence), a family risk factor of development or aggravation of the addictive behaviors.     

La substitution dans les études de représentations sociales : quel processus impliqué ?

This study of social representations aims at identifying the process involved in the responses produced with a substitution technique. Two alternative hypotheses are discussed: one that considers that substitution induces social comparison (Chokier and Moliner, 2006), the other suggesting that this technique leads to a reduction of normative pressures (Guimelli, 1998). In the research presented here, we studied the social representations of Drug addicts (in the tolerance towards the use of cannabis) and of Unemployed people, in order to compare the results with those obtained by Chokier and Moliner (2006) about security. With a specific population of students, these objects allowed us to manipulate two levels of distance to the object of representation. Concerning the technique of substitution, three levels of distance to the reference group (French people in general, Young people, Students) were combined into questionnaires with four types of instructions: standard, substitution, pro- and counter-normative. The PCA highlights a Guttman effect, which indicating that the responses produced with standard instruction are less normative than the responses produced with the substitution instruction to Young people. These results invalidate an explanation in terms of effect Primus Inter Pares. Globally, the results mainly show that the more the distance to the object is low and the distance to the reference group is high, the more the responses produce in substitution are seen as pro-normative and near from those produced with standard instruction. More specifically, we identified a number of inconsistencies with regard to what one could expect from an explanation of the phenomena in terms of personal versus social identity. As regards the representation of Unemployed people, the more the participants are closed to the reference group, the more the responses produced with an instruction of auto-valorization (pro-normative) are closed to those produced in substitution. However, on one hand, this result is observed only with the representation of Unemployed people, and, on the other hand, a social comparison explanation would suppose that the participants perceived the group of French people in general as homogeneous and identified themselves to this group at the same level than to the two other reference groups, which is unlikely. Finally, these results lead us to conclude that the substitution does not induce social comparison (Chokier and Moliner, 2006), but more probably reduction of normative pressures (Guimelli, 1998). It thus suggests that the study of masking effects through a substitution technique should take into account two parameters: distance to the object and distance to the reference group.     

Time processing in children with Tourette’s syndrome

Background

Tourette syndrome (TS) is characterized by dysfunctional connectivity between prefrontal cortex and sub-cortical structures, and altered meso-cortical and/or meso-striatal dopamine release. Since time processing is also regulated by fronto-striatal circuits and modulated by dopaminergic transmission, we hypothesized that time processing is abnormal in TS.

Methods

We compared time processing abilities between nine children with TS-only (i.e. without major psychiatric comorbidities) and 10 age-matched healthy children, employing a time reproduction task in which subjects actively reproduce different temporal intervals, and a time comparison task in which subjects judge whether a test interval is longer or shorter than a reference interval. IQ, sustained and divided attention, and working memory were assessed in both groups using the Leiter International Performance Scale-Revised, and the Digit Span sub-test of the WISC-R.

Results

Children with TS-only reproduced in an overestimated fashion over-second, but not sub-second, time intervals. The precision of over-second intervals reproduction correlated with tic severity, in that the lower the tic severity, the closer the reproduction of over-second time intervals to their real duration. Time reproduction performance did not significantly correlate with IQ, attention and working memory measures in both groups. No differences between groups were documented in the time comparison task.

Conclusions

The improvement of time processing in children with TS-only seems specific for the over-second range of intervals, consistent with an enhancement in the ‘cognitively controlled’ timing system, which mainly processes longer duration intervals, and depends upon dysfunctional connectivity between the basal ganglia and the dorso-lateral prefrontal cortex. The absence of between-group differences on time comparison, moreover, suggests that TS patients manifest a selective improvement of ‘motor’ timing abilities, rather than of perceptual time abilities. Our data also support an enhancement of cognitive control processes in TS children, probably facilitated by effortful tic suppression.