Effects of Hormone Replacement Therapy and Aging on Cognition: Evidence for Executive Dysfunction

ABSTRACT

The present study was designed to explore whether the frontal lobe hypothesis of cognitive aging may be extended to describe the cognitive effects associated with estrogen use in postmenopausal women. Postmenopausal estrogen-only users, estrogen + progesterone users, and non-users (60–80 years old), as well as young, regularly cycling women (18–30 years old) completed an item and source memory task. Since source memory is thought to rely more on executive processes than item memory, we hypothesized that aging and estrogen effects would be greater for source memory than for item memory. Neuropsychological tests explored whether the effects of aging and estrogen use were revealed on other tests of frontal lobe function. Results from the experimental task revealed greater aging and estrogen effects for source memory than for item memory, and neuropsychological results revealed aging and estrogen effects on a subset of tests of executive function. Women on estrogen + progesterone therapy did not outperform non-users, suggesting that the addition of progesterone to hormone therapy may mitigate the benefits induced by estrogen use alone. Overall, findings support the hypothesis that estrogen use may temper age-related cognitive decline by helping to maintain functions subserved by the frontal lobes.     

Age- and education-adjusted normative data for the Montreal Cognitive Assessment (MoCA) in older adults age 70–99

The original validation study for the Montreal Cognitive Assessment (MoCA) suggests a cutoff score of 26; however, this may be too stringent for older adults, particularly for those with less education. Given the rapidly increasing number of older adults and associated risk of dementia, this study aims to provide appropriate age- and education-adjusted norms for the MoCA. Data from 205 participants in an ongoing longevity study were used to derive normative data. Individuals were grouped based on age (70–79, 80–89, 90–99) and education level (≤12 Years, 13–15, ≥16 Years). There were significant differences between age and education groups with younger and more educated participants outperforming their counterparts. Forty-six percent of our sample scored below the suggested cutoff of 26. These normative data may provide a more accurate representation of MoCA performance in older adults for specific age and education stratifications.     

Test anxiety: contributions of gender,age, parent's occupation and self-esteem among secondary school students in Nigeria

Most of the previous studies on test anxiety have focused on students in higher institutions with little research on test anxiety in secondary school students. The present study examined the contributions of gender, age, parent's occupation and self-esteem on test anxiety among secondary school students. Participants were 281 students (males?=?156, females?=?125; mean age?=?17.05, SD?=?1.87) who were candidates for centralised, high-stakes examinations in two randomly selected secondary schools in Onitsha, Anambra state, Nigeria. Data were collected using questionnaires comprising the State Self-esteem Scale, the Test Anxiety Inventory and spaces for the provision of relevant socio-demographic information. Results of a hierarchical multiple regression analysis indicated that age and gender did not significantly contribute to test anxiety. Parent's occupation explained 2% of the variance in test anxiety and self-esteem contributed 10% in explaining test anxiety. Based on the findings, personal predispositions explain test anxiety among school students more than do their demographics.     

Antiquarian studies on ancient banqueting during the Renaissance

Abstract

During the Renaissance, studies on ancient banqueting became part of mainstream ancient history. Among the early treatments of the subject, the monumental treatise, Antiquitatum convivialium libri, written by the Swiss humanist and Reformed theologian, J. W. Stucki, was a notable breakthrough. The article argues that Stucki was the first humanist to conceive of ancient banqueting as having universal significance, influencing all later writers on the topic. In addition, he used his book as a resource to intervene in confessional disputes with data from antiquarian erudition. After Stucki’s publication and its censorship by the Roman Catholic Church, there was a significant boost in such works throughout Europe. The phenomenon was very heterogeneous in light of diversities relating to contrasting Protestant and Catholic regions. This article focuses on the development of different approaches to the topic arising from diverse religious and cultural backgrounds at the time.     

Slouching Toward Policy: Lazy Bioethics and the Perils of Science Fiction

Too much contemporary bioethical discourse is weak on science, lazily citing and adopting science fiction scenarios rather than science facts in the framing of analyses and policies. We challenge bioethicists to take more seriously the role of providing informed insight into and oversight over contemporary science and its implications and applications. Bioethicists must work harder to understand the fast-changing truths and limits of basic science, and they must incorporate only appropriate and authentic science into their discourse, just as they did in the past when addressing the quandaries of clinical medicine. The field of bioethics is not so old and entrenched that its future is assured. Bioethicists must make themselves useful to society in order to deserve and retain the public's trust. They can best do this by ensuring that decision making and public policy are grounded in facts, not fictions and fantasies.     

Confronting Deep Moral Disagreement: The President's Council on Bioethics,Moral Status,and Human Embryos

The report of the President's Council on Bioethics, Human Cloning and Human Dignity, addresses the central ethical, political, and policy issue in human embryonic stem cell research: the moral status of extracorporeal human embryos. The Council members were in sharp disagreement on this issue and essentially failed to adequately engage and respectfully acknowledge each others' deepest moral concerns, despite their stated commitment to do so. This essay provides a detailed critique of the two extreme views on the Council (i.e., embryos have full moral status or they have none at all) and then gives theoretical grounding for our judgment about the intermediate moral status of embryos. It also supplies an account of how to address profound moral disagreements in the public arena, especially by way of constructing a middle ground that deliberately pays sincere respect to the views of those with whom it has deep disagreements.     

Measuring child temperament: Validation of a 3‐item Temperament Measure and 13‐item Impulsivity Scale

A 3-item Temperament Measure and a 13-item Impulsivity Scale were tested against the 36-item Children's Behaviour Questionnaire (CBQ). Overall, 229 caregivers completed the CBQ and the 3-item Temperament Measure based on the traits of Surgency, Negative Affectivity and Effortful Control as measured by the CBQ. Their children completed the Impulsivity Scale. Psychometrics of the CBQ and the Impulsivity Scale were examined, which were considered good in terms of internal consistency and factorial structure. The three temperament items correlated with the average scores on the corresponding CBQ factors. Furthermore, Surgency was highly related to Impulsivity. Findings provide evidence for the applicability of the Impulsivity and Temperament Measures for research.     

Women's empowerment: the insights of Wangari Maathai

Wangari Maathai of Kenya has written about empowerment, practiced it in many ways in her own life, and shared her reflections on it with many other women in the Green Belt Movement. Yet to date, no study has been devoted to her ideas on the topic. This paper will highlight Maathai's insights regarding empowerment, tracing several important themes in her approach, namely, empowerment's relationship to self-esteem, teamwork, and political action, its ambivalent relationship to formal education, and the role of cultural traditions in providing alternatives to colonial-era cultural impositions and current exploitative effects of neo-liberal capitalism. After reviewing Maathai's thoughts on each of these topics, I will briefly draw upon other East African thinkers and Africanists' studies of East African communities to present corroborating evidence for Maathai's views or for challenges to her position. Listening to the perspectives of Maathai and other East Africans provides several important correctives to current popular uses of the term ‘empowerment’.     

Effect of click trains on duration estimates by people with Parkinson's disease

Patients with a diagnosis of Parkinson's disease and age- and IQ-matched controls estimated the duration of short 500-Hz tones (325–1,225 ms), on trials where the tone was either preceded by 3 s of 5-Hz clicks, or presented without clicks. The click manipulation had been shown in earlier studies with student participants to make verbal estimates longer. Patients were tested both on and off their dopaminergic medication, and controls were also tested in two sessions. Verbal estimates were markedly and significantly longer on trials with clicks than on those without clicks for both the patients and the controls, but there were no significant performance differences between patients or controls, nor between the on and off medication sessions in the patients. The study shows that a manipulation of subjective time, which has had small but consistent effects in student participants, also affects timing in patients and adds to a growing body of evidence that timing in patients with Parkinson's disease may in many cases have the same characteristics as those of neurologically intact control groups.     

In the Halfway House of Ill Repute: Gender Verification under a Different Name,Still No Contribution to Fair Play

The aftermath of Caster Semenya’s resounding victory in the women’s 800?m at the 2009 Athletics World Championships in Berlin highlighted the ethical and scientific flaws of gender verification in women’s athletics. It has led the governing international body of professional athletics, the International Association of Athletics Federations (IAAF), to adopt new rules regarding athletes with differences of sexual developments (DSDs) in women’s competitions in 2011 (Regulations on Hyperandrogenism). The International Olympic Committee followed suit and adopted a similar set of rules in 2012. Locating the practice of gender verification in a history of sexist stereotyping of women athletes (in Section 1), I argue (in Section 2), following other critics, that the IAAF’s new rules suffer from the same ethical flaws as their predecessors; and specifically that they still invite and rely on qualitative measuring of an athlete’s femininity and masculinity. In the central section of this paper (Section 3), I relate the practice of gender verification to the vexing question of what constitutes an unfair advantage in sports. I suggest, first, that athletes with a DSD should be at liberty to exploit competitive advantages their conditions might confer on them, just as most athletes in most sports are at liberty to exploit their congenital traits (the only irrelevant difference being that DSDs are construed as gendered advantages). In a second step, I argue that gender segregation in sports and gender verification practices cannot both be defended by an appeal to fairness. If we want to preserve gender segregation, then we ought to give up gender verification; and if we are not prepared to give up regulation of gendered congenital advantages, then we ought to give up gender segregation in favor of a classification system that tracks genetic predisposition rather than gender.