Chapter 6: Biblical Foundations for a Practical Theology of Aging

SUMMARY

This article reviews Biblical sources pertaining to the elderly, particularly the frail elderly. Founded on these sources, implications for elderly with Alzheimer's Disease and other forms of dementia are addressed through a personal perspective informed by writings of Christian mystics.     

Filial Piety: Buddhists' Way in East Asia

ABSTRACT

This article introduces the Buddhist way of practicing filial piety–repaying mothers' kindness–along with a Buddhist sutra, the Sutra about the Deep Kindness of Parents and the Difficulty of Repaying it. This sutra has been widely recited, upheld, and is endeared by East Asian people for centuries. The sutra became a vehicle that helped Buddhism assimilate with the indigenous cultural tradition of China. It contains discourses about the ten types of the kindness of a mother bestows on her child, difficulties of repaying kindness, the grave consequences of being unfilial toward parents, and how to repay kindness. The historical background of Buddhists' assimilation with the Chinese cultural system, emphasis given to the mother's kindness, and certain differences and similarities between Confucians and Buddhists in the practice of filial piety are discussed.     

The sure thing principle,dilations, and objective probabilities

The common theme that unites the four sections is STP, the sure thing principle. But the paper can be divided neatly into two parts. The first, consisting of the first two sections, contains an analysis of STP as it figures in Savage?s system and proposals of changes to that system. Also possibilities for partially ordered acts are considered. The second, consisting of the last two sections, is about imprecise probabilities, dilations and objective probabilities. Variants of STP are considered but this part is self-contained and can be read separately. The main claim there is that dilations, which can have extremely counterintuitive consequences, can be eliminated by a more careful analysis of the phenomenon. It outlines a proposal of how to do it. Here the concept of objective probabilities plays a crucial role.     

Childhood Anxiety Sensitivity Index Factors Predict Unique Variance in DSM‐IV Anxiety Disorder Symptoms

Anxiety sensitivity (AS) is an established cognitive risk factor for anxiety disorders. In children and adolescents, AS is usually measured with the Childhood Anxiety Sensitivity Index (CASI). Factor analytic studies suggest that the CASI is comprised of 3 lower‐order factors pertaining to Physical, Psychological and Social Concerns. There has been little research on the validity of these lower‐order factors. We examined the concurrent and incremental validity of the CASI and its lower‐order factors in a non‐clinical sample of 349 children and adolescents. CASI scores predicted symptoms of DSM‐IV anxiety disorder subtypes as measured by the Spence Children's Anxiety Scale (SCAS) after accounting for variance due to State‐Trait Anxiety Inventory scores. CASI Physical Concerns scores incrementally predicted scores on each of the SCAS scales, whereas scores on the Social and Psychological Concerns subscales incrementally predicted scores on conceptually related symptom scales (e.g. CASI Social Concerns scores predicted Social Phobia symptoms). Overall, this study demonstrates that there is added value in measuring AS factors in children and adolescents.     

On Chimeras

This essay is a critical response to Neville Cobbe's article “Cross‐Species Chimeras: Exploring a Possible Christian Perspective.” New technologies, particularly biotechnologies, raise major concerns in society. In the absence of good ethical thinking on these issues, bad ethical thinking becomes regnant. Two common types of bad ethical thinking are (1) confusing whatever disturbs people with genuine ethical issues and (2) confusing religious issues with ethical ones. Cobbe's article commits the former type of error with regard to the possibility of a mouse created with human brain neurons. I analyze and discuss that error and also raise questions about Cobbe's attempt to analyze the creation of chimeras from a Christian perspective.     

Can self-relevant stimuli help assessing patients with disorders of consciousness?

Emotional and self-relevant stimuli are able to automatically attract attention and their use in patients suffering from disorders of consciousness (DOC) might help detecting otherwise hidden signs of cognition.We here recorded EEG in three Locked-in syndrome (LIS) and four Vegetative State/Unresponsive Wakefulness Syndrome (VS/UWS) patients while they listened to the voice of a family member or an unfamiliar voice during a passive. Data indicate that, in a passive listening condition, the familiar voice induces stronger alpha desynchronization than the unfamiliar one. In an active condition, the target evoked stronger alpha desynchronization in controls, two LIS patients and one VS/UWS patient. Results suggest that self-relevant familiar voice stimuli can engage additional attentional resources and might allow the detection of otherwise hidden signs of instruction-following and thus residual awareness. Further studies are necessary to find sensitive paradigms that are suited to find subtle signs of cognition and awareness in DOC patients.     

Animal model of posterior cingulate cortex hypometabolism implicated in amnestic MCI and AD

The posterior cingulate cortex (PCC) is the brain region displaying the earliest sign of energy hypometabolism in patients with amnestic mild cognitive impairment (MCI) who develop Alzheimer’s disease (AD). In particular, the activity of the mitochondrial respiratory enzyme cytochrome oxidase (C.O.) is selectively inhibited within the PCC in AD. The present study is the first experimental analysis designed to model in animals the localized cortical C.O. inhibition found as the earliest metabolic sign of early-stage AD in human neuroimaging studies. Rats were used to model local inhibition of C.O. by direct injection of the C.O. inhibitor sodium azide into the PCC. Learning and memory were examined in a spatial holeboard task and brains were analyzed using quantitative histochemical, morphological and biochemical techniques. Behavioral results showed that sodium azide-treated rats were impaired in their memory of the baited pattern in probe trials as compared to their training scores before treatment, without non-specific behavioral differences. Brain analyses showed that C.O. inhibition was specific to the PCC, and sodium azide increased lipid peroxidation, gliosis and neuron loss, and lead to a network functional disconnection between the PCC and interconnected hippocampal regions. It was concluded that impaired memory by local C.O. inhibition in the PCC may serve to model in animals a metabolic lesion similar to that found in patients with amnestic MCI and early-stage AD. This model may be useful as an in vivo testing platform to investigate neuroprotective strategies to prevent or reduce the amnestic effects produced by posterior cingulate energy hypometabolism.     

“A Father’s Touch:” Negotiating Masculinity and Sexual Subjectivity in Child Care

This essay explores changing attitudes towards male caregivers in postwar America to understand conceptions of prepubescent gender and sexuality. While the 1950s have been viewed as a period of rigid gender conventions, the demands of a baby boom generation allowed men unexpected roles as caregivers. In the 1960s and 1970s, challenges to the status quo along with fears of female-headed households encouraged men to move into the field of child care, but this was particularly short lived. Political backlash and a failing economy turned male daycare workers into suspects, revealing the ambiguity that so often distorts children’s interactions with men.

Basal ganglia, dopamine and temporal processing: performance on three timing tasks on and off medication in Parkinson's disease

A pervasive hypothesis in the timing literature is that temporal processing in the milliseconds and seconds range engages the basal ganglia and is modulated by dopamine. This hypothesis was investigated by testing 12 patients with Parkinson's disease (PD), both 'on' and 'off' dopaminergic medication, and 20 healthy controls on three timing tasks. In a seconds range (30-120 s) time production task, patients tested 'on' medication showed a significantly different accuracy profile compared to controls and when tested 'off' medication. However, no group or on vs off medication differences in accuracy were found on a time reproduction task and a warned reaction time task requiring temporal processing within the 250-2000 ms range. Variability was measured using the coefficient of variation, with the performance of the patient group on the time reproduction task violating the scalar property, suggesting atypical temporal processing mechanisms. The data suggest that the integrity of the basal ganglia is necessary for 'typical' time production in the seconds range as well as for time reproduction at shorter intervals. Exploratory factor analysis suggested that the time production task uses neural mechanisms distinct from those used in the other two timing tasks. The dissociation of the effects of dopaminergic medication and nature of task on performance in PD raises interesting questions about the pharmacological mediation and task-specificity of deficits in temporal processing.     

Stimulus timing by people with Parkinson's disease

Previous literature suggests that Parkinson’s disease is marked by deficits in timed behaviour. However, the majority of studies of central timing mechanisms in patients with Parkinson’s disease have used timing tasks with a motor component. Since the motor abnormalities are a defining feature of the condition, the status of timing in Parkinson’s disease remains uncertain. Data are reported from patients with mild to moderate Parkinson’s disease (both on and off medication) and age- and IQ-matched controls on a range of stimulus timing tasks without counting. Tasks used were temporal generalization, bisection, threshold determination, verbal estimation, and a memory for duration task. Performance of patients was generally “normal” on all tasks, but significant differences from performance of controls were found on the memory for duration task. Among the “normal” effects noted were arithmetic mean bisection, asymmetric temporal generalization gradients, and subjective shortening on the memory for duration task. The results suggest (a) that some previous reports of timing “deficits” in Parkinson’s patients were possibly due to the use of tasks requiring a timed manual response and (b) small differences between patients and controls may be found on tasks where two stimuli are presented on each trial, whether patients are on medication or off it.