亲子依恋与儿童抑郁症状的关系：儿童对环境的生物敏感性的作用及父母差异

不良的亲子依恋是导致儿童抑郁症状的风险因素,但其对儿童的影响会因儿童对环境的生物敏感性不同而存在差异。为探究家庭中母子、父子依恋对儿童抑郁症状的影响及儿童生物敏感性(本文中采用迷走神经抑制作为指标)在其中的作用,本研究结合行为任务、问卷报告、生理测量等多种研究手段,招募150名学龄儿童(平均年龄8.64岁,63名女孩)参与研究。结果表明：(1)学龄儿童的母子依恋水平高于父子依恋水平。(2)高水平的母子依恋与父子依恋会同等程度地降低儿童的抑郁症状。(3)儿童对环境的生物敏感性对母子依恋影响儿童抑郁症状路径的调节作用显著,生理上对环境更敏感(高迷走神经抑制)的儿童更易得益于高母子依恋,表现出较低的抑郁水平;但同时,这类儿童在母子依恋较低时也更易表现出较高的抑郁水平。(4)儿童的生物敏感性对父子依恋影响儿童抑郁症状路径的调节作用不显著,高父子依恋对生物敏感性水平不同的儿童均存在有利影响。(5)在不同情境中测量的迷走神经抑制对亲子依恋影响儿童抑郁症状的调节作用模式相似,表现出跨情境一致的特点。本研究率先揭示儿童迷走神经抑制与亲子依恋对儿童抑郁症状的联合作用机制及父母角色差异。     

Episodic memory effects of gamma frequency precuneus transcranial magnetic stimulation in Alzheimer's disease: A randomized multiple baseline study

Episodic memory decline is the prominent neuropsychological feature of typical Alzheimer's Disease (AD), for which current treatments have a limited clinical response. Recently, gamma entrainment therapy has been used as a non-invasive treatment in AD, providing evidence that it may have the potential to alleviate brain pathology and improve cognitive function in AD patients. At the same time, the precuneus (PC) has been recognized as a key area involved in AD related memory deficits and as a key node of the Default Mode Network. This study aimed to investigate the effectiveness of a 40 Hz Transcranial Magnetic Stimulation (TMS) intervention, delivered bilaterally to the precuneus for 10 days, in improving the patients' episodic memory performance. Secondary outcome variables investigated included general cognitive function, semantic and spatial memory, as well as attention and executive function. A concurrent multiple baseline design across five cases was employed. Four patients completed the study. Visual analysis combined with effect size indices were used to evaluate changes across phases. An increase in the average level of immediate recalled words was observed in three out of four patients. Effect size indices indicated significant improvement of attention skills in two patients. No treatment effect was observed for semantic and visual memory, or for executive function. An immediate treatment effect was observed in all patients' general cognitive function as assessed with the Alzheimer's Disease Assessment Scale (mean reduction of 5 points), which was maintained and improved further three months post-treatment. The neuropsychological evaluations indicated improved performance three months post-treatment in immediate and delayed recall, attention, phonological verbal fluency, anxiety, and neuropsychiatric symptoms. This study provides preliminary evidence for the efficacy of a novel non-pharmacological treatment using gamma-band TMS in addressing cognitive dysfunction in AD.     

Lifespan normative data (18–89 years) for Raven's Advanced Progressive Matrices Set I

Raven's Advanced Progressive Matrices (APM) Set I is a validated and brief test of fluid intelligence, ideal for use in busy clinical settings. However, there is a dearth of normative data allowing an accurate interpretation of APM scores. To address this, we present normative data from across the adult lifespan (18–89 years) for the APM Set I. Data are presented in five age cohorts (total N = 352), including two older adult cohorts (65–79 years and 80–89 years), which allows age-standardized assessment. We also present data from a validated measure of premorbid intellectual ability, which was absent from previous standardizations of longer forms of the APM. In line with previous findings, a striking age-related decline was noted, beginning relatively early in adulthood and most marked amongst lower-scoring individuals. Older adults did not demonstrate difficulty with specific test items or make an increased proportion of specific errors. Sex was not a significant predictor of performance. The data set is of particular use in the neuropsychological assessment of older adults, given the known susceptibility of fluid intelligence to both the effects of normal ageing and acquired brain injury in older age. The results are discussed in light of theories of neurological ageing.     

ACHIEVING AND MAINTAINING COMPLIANCE WITH THE KETOGENIC DIET

The ketogenic diet, a treatment for intractable epilepsy, is rarely initiated because it requires strict compliance with a diet that is perceived to be unpalatable. In a case study of a 15-year-old girl with uncontrolled epilepsy, we used a stimulus-choice procedure to assess relative preferences of 33 foods from the diet and to develop two treatments based on Premack's principle. The results of a multielement analysis showed that both treatments increased dietary compliance. Compliance was maintained with generalization of treatment across settings, and was associated with a 40% reduction in seizures.     

SEQUENTIAL APPLICATION OF MAJOR HABIT-REVERSAL COMPONENTS TO TREAT MOTOR TICS IN CHILDREN

In this study, we sequentially administered up to four components of the habit-reversal treatment to 4 children with motor tics within a multiple baseline design. The habit-reversal components included (a) awareness training; (b) awareness training and self-monitoring; (c) awareness training, self-monitoring, and social support; and (d) awareness training, social support, and the use of a competing response. Results demonstrated that the combined use of awareness training, social support, and competing response training was effective in eliminating motor tics in 2 of 4 children, that awareness training alone was effective for 1 child, and that a combination of awareness training and self-monitoring was effective for the 4th child. The treatment and ensuing improvement were found to be socially valid. We discuss possible explanations for these results and recommend directions for future research.     

On optimal smoothing and derivative estimation from noisy displacement data in biomechanics

Estimating derivatives from noisy displacement data is a notoriously ill-posed problem in signal processing and biomechanics. Following the work of Wood and Jennings (1978) and Hatze (1979, 1981), the present paper describes the use of optimally regularized, natural quintic splines for estimating smoothed positions, velocities, and accelerations from equidistantly sampled, noisy position measurements. It appears that the nature of the boundary conditions of the data is of some importance, since various algorithms used hitherto result in artefacts throughout the data if the true derivatives at the record ends differ significantly from zero. Natural quintic splines do not suffer from this disadvantage below the third derivative.The ill-posed character of movement analysis has some interesting implications for movement synthesis and optimization, similar to the indeterminacy of muscular co-contraction from merely external, biomechanical measurements.     

Beyond the relational principle of reinforcement

Behavior under baseline conditions in which the contingency is absent can shed some light on the individual's performance under a schedule, but is insufficient as a basis for prediction of performance. This insufficiency of the baseline data runs counter to a recent formalization of the relational principle of reinforcement (Donahoe, 1977). A more satisfactory predictive model must incorporate not only the baseline level of the instrumental response and that of the contingent response, but also the schedule requirements, the character of each response in relation to the other, and the behavior required in simply switching from each to the other.     

The use of a self-control package to enhance temporal generality of a parent training program

The purpose of the present study was to examine the effectiveness of a self-control package in enhancing temporal generality of a parent training program. Sixteen mothers and their clinic-referred noncompliant children were assigned to either a parent training alone group, or a parent training plus self-control group. All mother-child dyads were treated individually by teaching the mother to reward compliance and other prosocial behavior, and to use time-out for noncompliance. In addition, mothers who also received self-control training learned to self-monitor their use of their new parenting skills and to reinforce themselves for use of the skill during a 2 month follow-up period. Assessment consisted of four home observations by independent observers prior to treatment, after treatment, and at a 2 month follow-up. The data indicated that the children in the parent training plus self-control group were significantly more compliant and less deviant at the 2 month follow-up than the children in the parent training alone group. Parental behavior did not differ between the two groups at the follow-up.     

Development of comprehension of sentences with “because” or “if”

The comprehension of sentences with “because” or “if” was investigated in children aged 2;9–11;11. Imitation, comprehension (choosing one of two picture sequences to go with a sentence), recognition (judging sentences with connective or structure differences as heard before or not), and synonymy (judging equivalence of meaning in sentences with different connectives or structures) tasks were administered, along with logical ordering, reversibility, and classification tasks. Above-chance responding in the comprehension task occurred by age 8, and in recognition and synonymy by age 10. Cognitive performance predicted 28.4% of the variance in the linguistic scores and cognitive success was concurrent with or preceded linguistic success. Comprehension of “because” and “if” appears to develop gradually, and is related to the development of certain operative rules.     

Visual processing of multielement arrays and selective backward masking

In the first of two selective masking experiments, 7-letter rows were followed at several ISIs by a mask or no-mask and a bar-marker partial report cue. The results suggest that the arrays were processed ends-first and then, in general, from both ends towards the middle. In the second experiment, bar-marker partial report cues were presented at the onset or offset of 6-letter/1-digit or 7-letter rows. The subjects could not anticipate the category of the to-be-reported item with the alphanumeric displays. With a delayed cue, selective masking was obtained with both mixed category and pure letter arrays, but with simultaneous cuing, masking was always distributed across all serial positions. The results suggest that the subjects: (a) abstracted some information about category from the mixed arrays during an initial parallel stage of processing, (b) selectively attended to mainly the cued item with simultaneous probes with homeogeneous and mixed category displays, and (c) employed an ends-first processing strategy with both types of arrays when the bar-marker partial report cue was delayed.