心房颤动发病机制研究历史的思考

心房颤动是临床最常见的心律失常之一,对其发病机制的研究已持续了上百年,对这一疾病的认识日益深入。对心房颤动发病机制的研究历史进行回顾和反思,使我们认识到科技的进步促进研究的深入,临床实践对理论创新提供了重要启示,有助于我们汲取经验,更好地开展研究。     

经导管射频消融术发展史及对医学教育的启示

自20世纪未,经导管射频消融术成功用于治疗快速心律失常,取得了瞩目的成就,本文回顾这一技术的发展史,认为它是理工科和医学高度结合的产物,提出医学教育与科研应该有理工医结合的环境。     

低位直肠癌保肛手术的哲学思辨

回顾直肠癌手术的发展史,追求根治与功能相互对立统一的发展过程。低位直肠癌保肛手术经历了长时间的对立、演化、发展,如今已经不再是手术技巧的问题,而是如何掌握保肛原则的问题。只有树立辩证唯物主义的世界观和方法论并用于实践,才能有助于进一步提高直肠癌的手术疗效。     

NARRATIVE AND MEANING IN SCIENCE AND RELIGION

Differences of understanding in science and in religion can be explored via the distinction between paradigmatic and narrative modes of explanation. Although science is inclusive of the paradigmatic, I propose that in explaining the behavior of complex adaptive systems, and in the human sciences in particular, narratives may well constitute the best scientific explanations. Causal relationships may be embedded within, and expressions of higher-order constraints provided by, complex system dynamics, best understood via the temporal organization of intentionalities that constitute narrative. Complex adaptive systems, out of which intentions emerge, have behavioral trajectories that are in principle unique, contingent, and nondeterministic even in stable states and unpredictable across phase transitions. Given such unpredictability, the only explanation can be an interpretive story that retrospectively retraces the actual changes in dynamics. Without narrative, personality traits and human actions are incomprehensible. Such phenomena do not permit a reduction of purposive acts to nonpurposive elements or of reasons to the causes they constrain. Causality does not exhaust meaning. Given the role of narratives in human lives, religion and mythology provide larger stories within which individual stories make sense. Differences between narrative and historical truth suggest how we can be constituted by what we imagine ourselves to be.     

Public good provision in inter‐team conflicts: Effects of asymmetry and profit‐sharing rule

A fundamental problem in organizations is designing mechanisms for eliciting voluntary contributions from individual members of a team who are entrapped in a social dilemma. To solve the problem, we utilize a game‐theoretical framework that embeds the traditional within‐team social dilemma in a between‐team competition for an exogenously determined prize. In equilibrium, such competition enhances the incentive to contribute, thereby reducing free‐riding. Extending existing literature, we focus on asymmetric competitions between teams of unequal size, and competitions between more than two teams. Comparing two protocols for sharing the prize—egalitarian and proportional profit‐sharing rules—we find that (i) free‐riding diminishes and (ii) team members contribute more toward their team's effort when they belong to the larger team and when the profit‐sharing rule is proportional. (iii) Additionally, under the egalitarian profit‐sharing rule team members contribute more than predicted by the equilibrium solution. We discuss implications of our findings for eliciting contributions in competitive environments. Copyright © 2009 John Wiley & Sons, Ltd.     

我国临床药学发展史的回顾及展望

临床药学是一门近几十年发展起来的新兴学科,是近年来我国一个备受关注的领域。它的产生及在我国的发展经历了一个曲折的过程,但却是历史发展的必然结果。纵观整个出现发展过程及现状,让我们思考了很多,对其今后的发展以及我们科学的认识事物有很好的启示。     

易学史研究与符号遮蔽——从惠栋研究误区出发

易学史研究中存在符号遮蔽问题,就表象而言,符号遮蔽问题与语言使用中的简化性有关,也受到循环历史观与进化历史观相互竞争的影响,从根本上言,遮蔽问题有其内在矛盾根源,即符号的无限与有限、开放与封闭、普遍与特殊的矛盾,解决遮蔽问题的关键在于还原符号内在的时间性、开放性与特殊性。     

氟哌啶醇与丙咪嗪交互作用对成本效益决策的影响

本实验采用T迷宫延迟奖赏模型研究多巴胺D2受体拮抗剂氟哌啶醇和5-羟色胺重摄取抑制剂丙咪嗪的交互作用对成本效益决策的影响, 同时探讨了延迟时间对决策的影响。T迷宫两臂分别设置为低成本-低奖赏端和高成本-高奖赏端。实验结果发现：氟哌啶醇能够降低大鼠选择高成本-高奖赏端的次数, 丙咪嗪则能够增加大鼠选择高成本-高奖赏端的次数; 在同时注射这两种药物情况下, 丙咪嗪能够抑制由氟哌啶醇引起的对低成本-低奖赏端的选择倾向。另外, 实验发现, 随延迟时间的增加大鼠选择高成本-高奖赏端的次数相对减少。由此可见, 丙咪嗪能够反转由氟哌啶醇导致的对低成本-低奖赏端的选择倾向, 这可能是由于细胞间5-羟色胺含量的升高部分反转了由多巴胺系统受损导致的行为倾向; 延迟时间的改变可对决策倾向产生逆转, 因此成本的支出即延迟时间也是影响成本效益决策的重要因素。     

Our Relations with the Past

The approach that philosophers have taken to history has too often been one-dimensional. It is my aim in this paper to map out a future multi-dimensional philosophy of history, by invoking the notion of a relation with the past, and by arguing for the philosophical relevance of multiple such relations.

论道德生活史研究的独特视阈及原则要求

道德生活史是一个国家和民族道德生活的历史叙述和再现,是以不同时期的道德生活为研究对象并力图揭示其发生发展线索的集描述性伦理学与规范性伦理学为一体的学科。道德生活史的研究因道德生活的本质特点决定了它有自己独特的研究视阈和原则要求。道德生活史的研究既是一种实证性的描述研究,同时又是一种规范性的价值研究,必须超越自然主义和超验主义的研究立场,而将自然主义与超验主义作一有机的整合,必须既联系伦理思想来进行研究但是又不能局限于伦理思想的研究,必须坚持事实与价值相统一、一元与多元相统一以及内容与形式相统一的研究原则。